A4D1S0 (KLRG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Killer cell lectin-like receptor subfamily G member 2

Alternative name(s):
C-type lectin domain family 15 member B

Gene names

Name:	KLRG2
Synonyms:	CLEC15B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A4D1S0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A4D1S0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: GLPMYVKSLY...HCYYFSAEAQ → DSLRTARTIW...DAAPPTGEAS
     313-409: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Killer cell lectin-like receptor subfamily G member 2		PRO_0000316792
Regions
	Transmembrane	263 – 283	21	Helical; Potential
	Domain	300 – 405	106	C-type lectin
	Compositional bias	18 – 159	142	Pro-rich
Amino acid modifications
	Disulfide bond	321 ↔ 404		By similarity
	Disulfide bond	383 ↔ 396		By similarity
Natural variations
	Alternative sequence	253 – 312	60	GLPMY…SAEAQ → DSLRTARTIWISTVGPWRKA RWWLQTAALQDPGSVPRGPS DLGSAWSSACQADAAPPTGE AS in isoform 2.		VSP_030779
	Alternative sequence	313 – 409	97	Missing in isoform 2.		VSP_030780
	Natural variant	152	1	K → T. Ref.3 Corresponds to variant rs1860150 [ dbSNP | Ensembl ].		VAR_038396
	Natural variant	339	1	G → A. Corresponds to variant rs17160911 [ dbSNP | Ensembl ].		VAR_038397
Experimental info
	Sequence conflict	109	1	A → V in EAL24036. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: E4AD53ED44E1240E	FASTA	409	42,851
	10 20 30 40 50 60 MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP AGAVEKAAGA 70 80 90 100 110 120 GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL VKLPRNGEAP GAEPAPSAWA 130 140 150 160 170 180 PMELQVDVRV KPVGAAGGSS TPSPRPSTRF LKVPVPESPA FSRHADPAHQ LLLRAPSQGG 190 200 210 220 230 240 TWGRRSPLAA ARTESGCDAE GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD 250 260 270 280 290 300 GDEKLPRAVT LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS 310 320 330 340 350 360 EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG AWRGPQGWHW 370 380 390 400 IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR PWVCAKGTQ
	Isoform 2 [UniParc]. Checksum: 7A0B08CE4951F603	FASTA	314	32,212
	10 20 30 40 50 60 MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP AGAVEKAAGA 70 80 90 100 110 120 GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL VKLPRNGEAP GAEPAPSAWA 130 140 150 160 170 180 PMELQVDVRV KPVGAAGGSS TPSPRPSTRF LKVPVPESPA FSRHADPAHQ LLLRAPSQGG 190 200 210 220 230 240 TWGRRSPLAA ARTESGCDAE GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD 250 260 270 280 290 300 GDEKLPRAVT LTDSLRTART IWISTVGPWR KARWWLQTAA LQDPGSVPRG PSDLGSAWSS 310 ACQADAAPPT GEAS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thymus.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-152.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK126174 mRNA. Translation: BAC86473.1. AC005531 Genomic DNA. No translation available. CH236950 Genomic DNA. Translation: EAL24036.1. BC104963 mRNA. Translation: AAI04964.1. BC104965 mRNA. Translation: AAI04966.1. BC110858 mRNA. Translation: AAI10859.1.
IPI	IPI00394851. IPI00719758.
RefSeq	NP_940910.1. NM_198508.2.
UniGene	Hs.741701.
3D structure databases
ProteinModelPortal	A4D1S0.
SMR	A4D1S0. Positions 293-406.
ModBase	Search...
Protein family/group databases
MEROPS	I63.002.
Proteomic databases
PaxDb	A4D1S0.
PRIDE	A4D1S0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340940; ENSP00000339356; ENSG00000188883. ENST00000393039; ENSP00000376759; ENSG00000188883.
GeneID	346689.
KEGG	hsa:346689.
UCSC	uc003vvb.3. human. uc010lnc.3. human.
Organism-specific databases
CTD	346689.
GeneCards	GC07M139137.
HGNC	HGNC:24778. KLRG2.
HPA	HPA018199.
neXtProt	NX_A4D1S0.
PharmGKB	PA162393624.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG239548.
HOGENOM	HOG000168488.
HOVERGEN	HBG108069.
InParanoid	A4D1S0.
OMA	CSAYHAT.
OrthoDB	EOG4894MZ.
PhylomeDB	A4D1S0.
Gene expression databases
Bgee	A4D1S0.
CleanEx	HS_KLRG2.
Genevestigator	A4D1S0.
Family and domain databases
Gene3D	3.10.100.10. 1 hit.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KLRG2. human.
GenomeRNAi	346689.
NextBio	99004.

Entry information

Entry name

KLRG2_HUMAN

Accession

Primary (citable) accession number: A4D1S0
Secondary accession number(s): Q2NL79, Q6ZTV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 11, 2011
Last modified:	April 3, 2013
This is version 51 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.