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Protein

Killer cell lectin-like receptor subfamily G member 2

Gene

KLRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-32678-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily G member 2
Alternative name(s):
C-type lectin domain family 15 member B
Gene namesi
Name:KLRG2
Synonyms:CLEC15B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:24778. KLRG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi346689.
OpenTargetsiENSG00000188883.
PharmGKBiPA162393624.

Polymorphism and mutation databases

BioMutaiKLRG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003167921 – 409Killer cell lectin-like receptor subfamily G member 2Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphoserineBy similarity1
Disulfide bondi321 ↔ 404PROSITE-ProRule annotation
Disulfide bondi383 ↔ 396PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiA4D1S0.
PaxDbiA4D1S0.
PRIDEiA4D1S0.

PTM databases

iPTMnetiA4D1S0.
PhosphoSitePlusiA4D1S0.

Expressioni

Gene expression databases

BgeeiENSG00000188883.
CleanExiHS_KLRG2.

Organism-specific databases

HPAiHPA018199.

Interactioni

Protein-protein interaction databases

BioGridi131397. 47 interactors.
STRINGi9606.ENSP00000339356.

Structurei

3D structure databases

ProteinModelPortaliA4D1S0.
SMRiA4D1S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 405C-type lectinPROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 159Pro-richAdd BLAST142

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00850000132371.
HOGENOMiHOG000168488.
HOVERGENiHBG108069.
InParanoidiA4D1S0.
OMAiCCRCKEL.
OrthoDBiEOG091G0APP.
PhylomeDBiA4D1S0.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4D1S0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP
60 70 80 90 100
AGAVEKAAGA GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL
110 120 130 140 150
VKLPRNGEAP GAEPAPSAWA PMELQVDVRV KPVGAAGGSS TPSPRPSTRF
160 170 180 190 200
LKVPVPESPA FSRHADPAHQ LLLRAPSQGG TWGRRSPLAA ARTESGCDAE
210 220 230 240 250
GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD GDEKLPRAVT
260 270 280 290 300
LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS
310 320 330 340 350
EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG
360 370 380 390 400
AWRGPQGWHW IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR

PWVCAKGTQ
Length:409
Mass (Da):42,851
Last modified:January 11, 2011 - v3
Checksum:iE4AD53ED44E1240E
GO
Isoform 2 (identifier: A4D1S0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: GLPMYVKSLY...HCYYFSAEAQ → DSLRTARTIW...DAAPPTGEAS
     313-409: Missing.

Show »
Length:314
Mass (Da):32,212
Checksum:i7A0B08CE4951F603
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → V in EAL24036 (PubMed:12690205).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038396152K → T.1 PublicationCorresponds to variant rs1860150dbSNPEnsembl.1
Natural variantiVAR_038397339G → A.Corresponds to variant rs17160911dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030779253 – 312GLPMY…SAEAQ → DSLRTARTIWISTVGPWRKA RWWLQTAALQDPGSVPRGPS DLGSAWSSACQADAAPPTGE AS in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_030780313 – 409Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126174 mRNA. Translation: BAC86473.1.
AC005531 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24036.1.
BC104963 mRNA. Translation: AAI04964.1.
BC104965 mRNA. Translation: AAI04966.1.
BC110858 mRNA. Translation: AAI10859.1.
CCDSiCCDS5854.1. [A4D1S0-1]
RefSeqiNP_940910.1. NM_198508.2. [A4D1S0-1]
UniGeneiHs.17572.

Genome annotation databases

EnsembliENST00000340940; ENSP00000339356; ENSG00000188883. [A4D1S0-1]
ENST00000393039; ENSP00000376759; ENSG00000188883. [A4D1S0-2]
GeneIDi346689.
KEGGihsa:346689.
UCSCiuc003vvb.4. human. [A4D1S0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126174 mRNA. Translation: BAC86473.1.
AC005531 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24036.1.
BC104963 mRNA. Translation: AAI04964.1.
BC104965 mRNA. Translation: AAI04966.1.
BC110858 mRNA. Translation: AAI10859.1.
CCDSiCCDS5854.1. [A4D1S0-1]
RefSeqiNP_940910.1. NM_198508.2. [A4D1S0-1]
UniGeneiHs.17572.

3D structure databases

ProteinModelPortaliA4D1S0.
SMRiA4D1S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131397. 47 interactors.
STRINGi9606.ENSP00000339356.

PTM databases

iPTMnetiA4D1S0.
PhosphoSitePlusiA4D1S0.

Polymorphism and mutation databases

BioMutaiKLRG2.

Proteomic databases

MaxQBiA4D1S0.
PaxDbiA4D1S0.
PRIDEiA4D1S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340940; ENSP00000339356; ENSG00000188883. [A4D1S0-1]
ENST00000393039; ENSP00000376759; ENSG00000188883. [A4D1S0-2]
GeneIDi346689.
KEGGihsa:346689.
UCSCiuc003vvb.4. human. [A4D1S0-1]

Organism-specific databases

CTDi346689.
DisGeNETi346689.
GeneCardsiKLRG2.
HGNCiHGNC:24778. KLRG2.
HPAiHPA018199.
neXtProtiNX_A4D1S0.
OpenTargetsiENSG00000188883.
PharmGKBiPA162393624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00850000132371.
HOGENOMiHOG000168488.
HOVERGENiHBG108069.
InParanoidiA4D1S0.
OMAiCCRCKEL.
OrthoDBiEOG091G0APP.
PhylomeDBiA4D1S0.
TreeFamiTF351467.

Enzyme and pathway databases

BioCyciZFISH:G66-32678-MONOMER.

Miscellaneous databases

ChiTaRSiKLRG2. human.
GenomeRNAii346689.
PROiA4D1S0.

Gene expression databases

BgeeiENSG00000188883.
CleanExiHS_KLRG2.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLRG2_HUMAN
AccessioniPrimary (citable) accession number: A4D1S0
Secondary accession number(s): Q2NL79, Q6ZTV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.