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A4D1S0

- KLRG2_HUMAN

UniProt

A4D1S0 - KLRG2_HUMAN

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Protein

Killer cell lectin-like receptor subfamily G member 2

Gene

KLRG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily G member 2
Alternative name(s):
C-type lectin domain family 15 member B
Gene namesi
Name:KLRG2
Synonyms:CLEC15B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:24778. KLRG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Killer cell lectin-like receptor subfamily G member 2PRO_0000316792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi321 ↔ 404PROSITE-ProRule annotation
Disulfide bondi383 ↔ 396PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiA4D1S0.
PaxDbiA4D1S0.
PRIDEiA4D1S0.

Expressioni

Gene expression databases

BgeeiA4D1S0.
CleanExiHS_KLRG2.
GenevestigatoriA4D1S0.

Organism-specific databases

HPAiHPA018199.

Interactioni

Protein-protein interaction databases

BioGridi131397. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA4D1S0.
SMRiA4D1S0. Positions 293-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 405106C-type lectinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 159142Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239548.
GeneTreeiENSGT00710000106527.
HOGENOMiHOG000168488.
HOVERGENiHBG108069.
InParanoidiA4D1S0.
OMAiCCRCKEL.
OrthoDBiEOG7RZ5QC.
PhylomeDBiA4D1S0.
TreeFamiTF351467.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A4D1S0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP
60 70 80 90 100
AGAVEKAAGA GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL
110 120 130 140 150
VKLPRNGEAP GAEPAPSAWA PMELQVDVRV KPVGAAGGSS TPSPRPSTRF
160 170 180 190 200
LKVPVPESPA FSRHADPAHQ LLLRAPSQGG TWGRRSPLAA ARTESGCDAE
210 220 230 240 250
GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD GDEKLPRAVT
260 270 280 290 300
LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS
310 320 330 340 350
EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG
360 370 380 390 400
AWRGPQGWHW IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR

PWVCAKGTQ
Length:409
Mass (Da):42,851
Last modified:January 11, 2011 - v3
Checksum:iE4AD53ED44E1240E
GO
Isoform 2 (identifier: A4D1S0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: GLPMYVKSLY...HCYYFSAEAQ → DSLRTARTIW...DAAPPTGEAS
     313-409: Missing.

Show »
Length:314
Mass (Da):32,212
Checksum:i7A0B08CE4951F603
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091A → V in EAL24036. (PubMed:12690205)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521K → T.1 Publication
Corresponds to variant rs1860150 [ dbSNP | Ensembl ].
VAR_038396
Natural varianti339 – 3391G → A.
Corresponds to variant rs17160911 [ dbSNP | Ensembl ].
VAR_038397

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei253 – 31260GLPMY…SAEAQ → DSLRTARTIWISTVGPWRKA RWWLQTAALQDPGSVPRGPS DLGSAWSSACQADAAPPTGE AS in isoform 2. 1 PublicationVSP_030779Add
BLAST
Alternative sequencei313 – 40997Missing in isoform 2. 1 PublicationVSP_030780Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126174 mRNA. Translation: BAC86473.1.
AC005531 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24036.1.
BC104963 mRNA. Translation: AAI04964.1.
BC104965 mRNA. Translation: AAI04966.1.
BC110858 mRNA. Translation: AAI10859.1.
CCDSiCCDS5854.1. [A4D1S0-1]
RefSeqiNP_940910.1. NM_198508.2. [A4D1S0-1]
UniGeneiHs.17572.

Genome annotation databases

EnsembliENST00000340940; ENSP00000339356; ENSG00000188883. [A4D1S0-1]
ENST00000393039; ENSP00000376759; ENSG00000188883. [A4D1S0-2]
GeneIDi346689.
KEGGihsa:346689.
UCSCiuc003vvb.3. human. [A4D1S0-1]
uc010lnc.3. human. [A4D1S0-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126174 mRNA. Translation: BAC86473.1 .
AC005531 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24036.1 .
BC104963 mRNA. Translation: AAI04964.1 .
BC104965 mRNA. Translation: AAI04966.1 .
BC110858 mRNA. Translation: AAI10859.1 .
CCDSi CCDS5854.1. [A4D1S0-1 ]
RefSeqi NP_940910.1. NM_198508.2. [A4D1S0-1 ]
UniGenei Hs.17572.

3D structure databases

ProteinModelPortali A4D1S0.
SMRi A4D1S0. Positions 293-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131397. 2 interactions.

Proteomic databases

MaxQBi A4D1S0.
PaxDbi A4D1S0.
PRIDEi A4D1S0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340940 ; ENSP00000339356 ; ENSG00000188883 . [A4D1S0-1 ]
ENST00000393039 ; ENSP00000376759 ; ENSG00000188883 . [A4D1S0-2 ]
GeneIDi 346689.
KEGGi hsa:346689.
UCSCi uc003vvb.3. human. [A4D1S0-1 ]
uc010lnc.3. human. [A4D1S0-2 ]

Organism-specific databases

CTDi 346689.
GeneCardsi GC07M139137.
HGNCi HGNC:24778. KLRG2.
HPAi HPA018199.
neXtProti NX_A4D1S0.
PharmGKBi PA162393624.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239548.
GeneTreei ENSGT00710000106527.
HOGENOMi HOG000168488.
HOVERGENi HBG108069.
InParanoidi A4D1S0.
OMAi CCRCKEL.
OrthoDBi EOG7RZ5QC.
PhylomeDBi A4D1S0.
TreeFami TF351467.

Miscellaneous databases

ChiTaRSi KLRG2. human.
GenomeRNAii 346689.
NextBioi 99004.
PROi A4D1S0.

Gene expression databases

Bgeei A4D1S0.
CleanExi HS_KLRG2.
Genevestigatori A4D1S0.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thymus.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-152.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLRG2_HUMAN
AccessioniPrimary (citable) accession number: A4D1S0
Secondary accession number(s): Q2NL79, Q6ZTV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3