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A4D1S0

- KLRG2_HUMAN

UniProt

A4D1S0 - KLRG2_HUMAN

Protein

Killer cell lectin-like receptor subfamily G member 2

Gene

KLRG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell lectin-like receptor subfamily G member 2
    Alternative name(s):
    C-type lectin domain family 15 member B
    Gene namesi
    Name:KLRG2
    Synonyms:CLEC15B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:24778. KLRG2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162393624.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Killer cell lectin-like receptor subfamily G member 2PRO_0000316792Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi321 ↔ 404PROSITE-ProRule annotation
    Disulfide bondi383 ↔ 396PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiA4D1S0.
    PaxDbiA4D1S0.
    PRIDEiA4D1S0.

    Expressioni

    Gene expression databases

    BgeeiA4D1S0.
    CleanExiHS_KLRG2.
    GenevestigatoriA4D1S0.

    Organism-specific databases

    HPAiHPA018199.

    Structurei

    3D structure databases

    ProteinModelPortaliA4D1S0.
    SMRiA4D1S0. Positions 293-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini300 – 405106C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 159142Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239548.
    HOGENOMiHOG000168488.
    HOVERGENiHBG108069.
    InParanoidiA4D1S0.
    OMAiCCRCKEL.
    OrthoDBiEOG7RZ5QC.
    PhylomeDBiA4D1S0.
    TreeFamiTF351467.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A4D1S0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP    50
    AGAVEKAAGA GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL 100
    VKLPRNGEAP GAEPAPSAWA PMELQVDVRV KPVGAAGGSS TPSPRPSTRF 150
    LKVPVPESPA FSRHADPAHQ LLLRAPSQGG TWGRRSPLAA ARTESGCDAE 200
    GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD GDEKLPRAVT 250
    LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS 300
    EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG 350
    AWRGPQGWHW IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR 400
    PWVCAKGTQ 409
    Length:409
    Mass (Da):42,851
    Last modified:January 11, 2011 - v3
    Checksum:iE4AD53ED44E1240E
    GO
    Isoform 2 (identifier: A4D1S0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         253-312: GLPMYVKSLY...HCYYFSAEAQ → DSLRTARTIW...DAAPPTGEAS
         313-409: Missing.

    Show »
    Length:314
    Mass (Da):32,212
    Checksum:i7A0B08CE4951F603
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091A → V in EAL24036. (PubMed:12690205)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521K → T.1 Publication
    Corresponds to variant rs1860150 [ dbSNP | Ensembl ].
    VAR_038396
    Natural varianti339 – 3391G → A.
    Corresponds to variant rs17160911 [ dbSNP | Ensembl ].
    VAR_038397

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei253 – 31260GLPMY…SAEAQ → DSLRTARTIWISTVGPWRKA RWWLQTAALQDPGSVPRGPS DLGSAWSSACQADAAPPTGE AS in isoform 2. 1 PublicationVSP_030779Add
    BLAST
    Alternative sequencei313 – 40997Missing in isoform 2. 1 PublicationVSP_030780Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126174 mRNA. Translation: BAC86473.1.
    AC005531 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24036.1.
    BC104963 mRNA. Translation: AAI04964.1.
    BC104965 mRNA. Translation: AAI04966.1.
    BC110858 mRNA. Translation: AAI10859.1.
    CCDSiCCDS5854.1. [A4D1S0-1]
    RefSeqiNP_940910.1. NM_198508.2. [A4D1S0-1]
    UniGeneiHs.17572.

    Genome annotation databases

    EnsembliENST00000340940; ENSP00000339356; ENSG00000188883. [A4D1S0-1]
    ENST00000393039; ENSP00000376759; ENSG00000188883. [A4D1S0-2]
    GeneIDi346689.
    KEGGihsa:346689.
    UCSCiuc003vvb.3. human. [A4D1S0-1]
    uc010lnc.3. human. [A4D1S0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126174 mRNA. Translation: BAC86473.1 .
    AC005531 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24036.1 .
    BC104963 mRNA. Translation: AAI04964.1 .
    BC104965 mRNA. Translation: AAI04966.1 .
    BC110858 mRNA. Translation: AAI10859.1 .
    CCDSi CCDS5854.1. [A4D1S0-1 ]
    RefSeqi NP_940910.1. NM_198508.2. [A4D1S0-1 ]
    UniGenei Hs.17572.

    3D structure databases

    ProteinModelPortali A4D1S0.
    SMRi A4D1S0. Positions 293-406.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi A4D1S0.
    PaxDbi A4D1S0.
    PRIDEi A4D1S0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340940 ; ENSP00000339356 ; ENSG00000188883 . [A4D1S0-1 ]
    ENST00000393039 ; ENSP00000376759 ; ENSG00000188883 . [A4D1S0-2 ]
    GeneIDi 346689.
    KEGGi hsa:346689.
    UCSCi uc003vvb.3. human. [A4D1S0-1 ]
    uc010lnc.3. human. [A4D1S0-2 ]

    Organism-specific databases

    CTDi 346689.
    GeneCardsi GC07M139137.
    HGNCi HGNC:24778. KLRG2.
    HPAi HPA018199.
    neXtProti NX_A4D1S0.
    PharmGKBi PA162393624.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239548.
    HOGENOMi HOG000168488.
    HOVERGENi HBG108069.
    InParanoidi A4D1S0.
    OMAi CCRCKEL.
    OrthoDBi EOG7RZ5QC.
    PhylomeDBi A4D1S0.
    TreeFami TF351467.

    Miscellaneous databases

    ChiTaRSi KLRG2. human.
    GenomeRNAii 346689.
    NextBioi 99004.
    PROi A4D1S0.

    Gene expression databases

    Bgeei A4D1S0.
    CleanExi HS_KLRG2.
    Genevestigatori A4D1S0.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thymus.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-152.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKLRG2_HUMAN
    AccessioniPrimary (citable) accession number: A4D1S0
    Secondary accession number(s): Q2NL79, Q6ZTV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 62 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3