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Protein

WD repeat-containing protein 91

Gene

WDR91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).By similarity2 Publications

GO - Molecular functioni

  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB

GO - Biological processi

  • early endosome to late endosome transport Source: UniProtKB
  • regulation of cellular protein catabolic process Source: UniProtKB
  • regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB

Enzyme and pathway databases

SignaLinkiA4D1P6.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 91Imported
Gene namesi
Name:WDR91Imported
ORF Names:HSPC049Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105875.13.
HGNCiHGNC:24997. WDR91.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105875.
PharmGKBiPA162409166.

Polymorphism and mutation databases

BioMutaiWDR91.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957461 – 747WD repeat-containing protein 91Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA4D1P6.
MaxQBiA4D1P6.
PaxDbiA4D1P6.
PRIDEiA4D1P6.

PTM databases

iPTMnetiA4D1P6.
PhosphoSitePlusiA4D1P6.

Expressioni

Gene expression databases

BgeeiENSG00000105875.
CleanExiHS_WDR91.
ExpressionAtlasiA4D1P6. baseline and differential.
GenevisibleiA4D1P6. HS.

Organism-specific databases

HPAiHPA024260.

Interactioni

Subunit structurei

Interacts with WDR81; involved in early to late endosome cargo transport (PubMed:26783301, PubMed:27126989). Interacts with BECN1; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes (PubMed:26783301).2 Publications

Protein-protein interaction databases

BioGridi118837. 18 interactors.
IntActiA4D1P6. 8 interactors.
MINTiMINT-4716115.
STRINGi9606.ENSP00000346466.

Structurei

3D structure databases

ProteinModelPortaliA4D1P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati406 – 445WD 1Add BLAST40
Repeati448 – 488WD 2Add BLAST41
Repeati515 – 555WD 3Add BLAST41
Repeati560 – 599WD 4Add BLAST40
Repeati602 – 641WD 5Add BLAST40
Repeati664 – 702WD 6Add BLAST39
Repeati709 – 747WD 7Add BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili183 – 215Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the WD repeat WDR91 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1333. Eukaryota.
ENOG410XQIX. LUCA.
GeneTreeiENSGT00390000001566.
HOVERGENiHBG057115.
InParanoidiA4D1P6.
OMAiDSEGNYM.
OrthoDBiEOG091G0ATH.
PhylomeDBiA4D1P6.
TreeFamiTF317339.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4D1P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ
60 70 80 90 100
QLMQVYDLAA LRDYWSYLER RLFSRLEDIY RPTIHKLKTS LFRFYLVYTI
110 120 130 140 150
QTNRNDKAQE FFAKQATELQ NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ
160 170 180 190 200
WADTFIVSLH NFLSVLFQCM PVPVILNFDA ECQRTNQVQE ENEVLRQKLF
210 220 230 240 250
ALQAEIHRLK KEEQQPEEEE ALVQHKLPPY VSNMDRLGDS ELAMVCSQRN
260 270 280 290 300
ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQPQSSAK KESFGGQGTK
310 320 330 340 350
GKDPTSGAKD GKSLLSGLAT GESGWSQHRQ RRLQDHGKER KELFSTTTSQ
360 370 380 390 400
CAEKKPEASG PEAEPCPELH TEPVEPLTRA SSAGPEGGGV RPEQPFIVLG
410 420 430 440 450
QEEYGEHHSS IMHCRVDCSG RRVASLDVDG VIKVWSFNPI MQTKASSISK
460 470 480 490 500
SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT EAKKNLCEIN INDNMPRILS
510 520 530 540 550
LACSPNGASF VCSAAAPSLT SQVDFSAPDI GSKGMNQVPG RLLLWDTKTM
560 570 580 590 600
KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHECAMSW
610 620 630 640 650
RAHYGEVYSV EFSYDENTVY SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT
660 670 680 690 700
GPFVLSGYSG YKQVQVPRGR LFAFDSEGNY MLTCSATGGV IYKLGGDEKV
710 720 730 740
LESCLSLGGH RAPVVTVDWS TAMDCGTCLT ASMDGKIKLT TLLAHKA
Length:747
Mass (Da):83,344
Last modified:November 30, 2010 - v2
Checksum:iA93CF7F02D12629A
GO
Isoform 2 (identifier: A4D1P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-636: DMQQHECAMS...KFIQWNIHKS → VHPVEHPQEW...SSPQGPTLRF
     637-747: Missing.

Note: No experimental confirmation available.
Show »
Length:636
Mass (Da):71,352
Checksum:iBF7826528F2047B5
GO
Isoform 3 (identifier: A4D1P6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-365: CAEKKPEASGPEAEP → VWGCPEHPWGHSCSY
     366-747: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):42,112
Checksum:i8E984767FD792012
GO

Sequence cautioni

The sequence AAF29021 differs from that shown. Reason: Frameshift at positions 136, 161, 166, 381, 392, 400, 405, 424, 442, 448, 458, 462, 501, 505, 508, 605, 626, 646, 712 and 736.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302K → R in BAA91785 (PubMed:14702039).Curated1
Sequence conflicti449S → F in AAF29021 (PubMed:11042152).Curated1
Sequence conflicti510F → L in AAF29021 (PubMed:11042152).Curated1
Sequence conflicti706S → K in AAF29021 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033358257P → L6 PublicationsCorresponds to variant dbSNP:rs292592Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027058351 – 365CAEKK…PEAEP → VWGCPEHPWGHSCSY in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_027059366 – 747Missing in isoform 3. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_027060590 – 636DMQQH…NIHKS → VHPVEHPQEWPQGIRVQPPL RCHGPLCAVWIQRLQAGSSP QGPTLRF in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_027061637 – 747Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161534 mRNA. Translation: AAF29021.1. Frameshift.
AK001606 mRNA. Translation: BAA91785.1.
AK022935 mRNA. Translation: BAB14316.1.
BX640957 mRNA. Translation: CAE45977.1.
AC009542 Genomic DNA. No translation available.
AC083862 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24062.1.
BC009939 mRNA. Translation: AAH09939.2.
BC017246 mRNA. Translation: AAH17246.1.
BC063394 mRNA. Translation: AAH63394.1.
AL136940 mRNA. Translation: CAB66874.2.
CR533561 mRNA. Translation: CAG38592.1.
CCDSiCCDS34758.1. [A4D1P6-1]
RefSeqiNP_054868.3. NM_014149.3. [A4D1P6-1]
UniGeneiHs.459858.

Genome annotation databases

EnsembliENST00000354475; ENSP00000346466; ENSG00000105875. [A4D1P6-1]
GeneIDi29062.
KEGGihsa:29062.
UCSCiuc003vsp.3. human. [A4D1P6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR91_HUMAN
AccessioniPrimary (citable) accession number: A4D1P6
Secondary accession number(s): A6NK54
, C9JMI4, Q6FI65, Q6MZQ1, Q6P4I1, Q96AE5, Q96G63, Q9H062, Q9H9B6, Q9NVG7, Q9NZY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 30, 2010
Last modified: November 22, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families