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Protein

MICOS complex subunit

Gene

CHCHD3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunitUniRule annotation
Gene namesi
Name:CHCHD3Imported
ORF Names:hCG_2014841Imported, tcag7.1158Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000106554.11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983108

PTM / Processingi

Keywords - PTMi

Lipoprotein, MyristateUniRule annotation

Proteomic databases

PRIDEiA4D1N4

Expressioni

Gene expression databases

BgeeiENSG00000106554
ExpressionAtlasiA4D1N4 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA4D1N4, 1 interactor

Structurei

3D structure databases

SMRiA4D1N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 108UniRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic19 family.UniRule annotation

Keywords - Domaini

Coiled coilUniRule annotation

Phylogenomic databases

eggNOGiKOG4083 Eukaryota
ENOG41126BR LUCA
HOVERGENiHBG050936
KOiK17563

Family and domain databases

InterProiView protein in InterPro
IPR007964 MIC19/MIC25
PfamiView protein in Pfam
PF05300 DUF737, 2 hits

Sequencei

Sequence statusi: Complete.

A4D1N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTTSTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS
60 70 80 90 100
GAYGASVSDE ELKRRVAEEL ALEQAKKESE DQKRLKQAKE LDRERAAANE
110 120 130 140 150
QLTRAILRER ICSEEERAKA KHLARQLEEK DRVLKKQDAF YKEQLARLEE
160 170 180 190 200
RSSEFYRVTT EQYQKAAEEV EAKFKRYESH PVCADLQAKI LQCYRENTHQ
210 220
TLKCSALATQ YMHCVNHAKQ SMLEKGG
Length:227
Mass (Da):26,152
Last modified:April 3, 2007 - v1
Checksum:i569E405EB7C801D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA Translation: EAL24074.1
CH471070 Genomic DNA Translation: EAW83803.1
RefSeqiNP_060282.1, NM_017812.3
UniGeneiHs.655010

Genome annotation databases

GeneIDi54927
KEGGihsa:54927

Similar proteinsi

Entry informationi

Entry nameiA4D1N4_HUMAN
AccessioniPrimary (citable) accession number: A4D1N4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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