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Protein

MICOS complex subunit

Gene

CHCHD3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunitUniRule annotation
Gene namesi
Name:CHCHD3Imported
ORF Names:hCG_2014841Imported, tcag7.1158Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983108.

PTM / Processingi

Keywords - PTMi

Lipoprotein, MyristateUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000106554.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000262570.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili72 – 10837UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic19 family.UniRule annotation

Keywords - Domaini

Coiled coilUniRule annotation

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
HOVERGENiHBG050936.
KOiK17563.
PhylomeDBiA4D1N4.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D1N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTTSTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS
60 70 80 90 100
GAYGASVSDE ELKRRVAEEL ALEQAKKESE DQKRLKQAKE LDRERAAANE
110 120 130 140 150
QLTRAILRER ICSEEERAKA KHLARQLEEK DRVLKKQDAF YKEQLARLEE
160 170 180 190 200
RSSEFYRVTT EQYQKAAEEV EAKFKRYESH PVCADLQAKI LQCYRENTHQ
210 220
TLKCSALATQ YMHCVNHAKQ SMLEKGG
Length:227
Mass (Da):26,152
Last modified:April 3, 2007 - v1
Checksum:i569E405EB7C801D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA. Translation: EAL24074.1.
CH471070 Genomic DNA. Translation: EAW83803.1.
RefSeqiNP_060282.1. NM_017812.3.
UniGeneiHs.655010.

Genome annotation databases

GeneIDi54927.
KEGGihsa:54927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA. Translation: EAL24074.1.
CH471070 Genomic DNA. Translation: EAW83803.1.
RefSeqiNP_060282.1. NM_017812.3.
UniGeneiHs.655010.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262570.

Protocols and materials databases

DNASUi54927.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54927.
KEGGihsa:54927.

Organism-specific databases

CTDi54927.
PharmGKBiPA134983108.

Phylogenomic databases

eggNOGiKOG4083. Eukaryota.
ENOG41126BR. LUCA.
HOVERGENiHBG050936.
KOiK17563.
PhylomeDBiA4D1N4.

Miscellaneous databases

ChiTaRSiCHCHD3. human.
GenomeRNAii54927.

Gene expression databases

BgeeiENSG00000106554.

Family and domain databases

InterProiIPR007964. DUF737.
[Graphical view]
PfamiPF05300. DUF737. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4D1N4_HUMAN
AccessioniPrimary (citable) accession number: A4D1N4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.