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Protein
Submitted name:

Carboxypeptidase A4

Gene

CPA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidaseImported, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Submitted name:
Carboxypeptidase A4Imported
Submitted name:
Carboxypeptidase A4, isoform CRA_aImported
Submitted name:
cDNA FLJ75086, highly similar to Homo sapiens carboxypeptidase A4, mRNAImported
Gene namesi
Name:CPA4Imported
ORF Names:hCG_18973Imported, tcag7.359Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000128510.10

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501429686317 – 421Sequence analysisAdd BLAST405

Proteomic databases

PRIDEiA4D1M3

Expressioni

Gene expression databases

BgeeiENSG00000128510
ExpressionAtlasiA4D1M3 baseline and differential

Structurei

3D structure databases

SMRiA4D1M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 194Peptidase_M14InterPro annotationAdd BLAST23
Domaini308 – 318Peptidase_M14InterPro annotationAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili91 – 111Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2650 Eukaryota
COG2866 LUCA
HOVERGENiHBG050815
KOiK08637
OMAiIQKHGNF
OrthoDBiEOG091G0HUI

Family and domain databases

CDDicd03870 M14_CPA, 1 hit
Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR034248 CPA_M14_CPD
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
PROSITEiView protein in PROSITE
PS00132 CARBOXYPEPT_ZN_1, 1 hit
PS00133 CARBOXYPEPT_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4D1M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWILFIGAL IGSSICGQEK FFGDQVLRIN VRNGDEISKL SQLVNSNNLK
60 70 80 90 100
LNFWKSPSSF NRPVDVLVPS VSLQAFKSFL RSQGLEYAVT IEDLQALLDN
110 120 130 140 150
EDDEMQHNEG QERSSNNFNY GAYHSLEAIY HEMDNIAADF PDLARRVKIG
160 170 180 190 200
HSFENRPMYV LKFSTGKGVR RPAVWLNAGI HSREWISQAT AIWTARKIVS
210 220 230 240 250
DYQRDPAITS ILEKMDIFLL PVANPDGYVY TQTQNRLWRK TRSRNPGSSC
260 270 280 290 300
IGADPNRNWN ASFAGKGASD NPCSEVYHGP HANSEVEVKS VVDFIQKHGN
310 320 330 340 350
FKGFIDLHSY SQLLMYPYGY SVKKAPDAEE LDKVARLAAK ALASVSGTEY
360 370 380 390 400
QVGPTCTTVY PASGSSIDWA YDNGIKFAFT FELRDTGTYG FLLPANQIIP
410 420
TAEETWLGLK TIMEHVRDNL Y
Length:421
Mass (Da):47,351
Last modified:April 3, 2007 - v1
Checksum:i52750CC50B470EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290993 mRNA Translation: BAF83682.1
CH236950 Genomic DNA Translation: EAL24091.1
CH471070 Genomic DNA Translation: EAW83752.1
CH471070 Genomic DNA Translation: EAW83753.1
RefSeqiNP_057436.2, NM_016352.3
UniGeneiHs.93764

Genome annotation databases

GeneIDi51200
KEGGihsa:51200

Similar proteinsi

Entry informationi

Entry nameiA4D1M3_HUMAN
AccessioniPrimary (citable) accession number: A4D1M3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health