Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Carboxypeptidase A4

Gene

CPA4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseSAAS annotationImported, Hydrolase, MetalloproteaseSAAS annotation, Protease

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Carboxypeptidase A4Imported
Submitted name:
Carboxypeptidase A4, isoform CRA_aImported
Submitted name:
cDNA FLJ75086, highly similar to Homo sapiens carboxypeptidase A4, mRNAImported
Gene namesi
Name:CPA4Imported
ORF Names:hCG_18973Imported, tcag7.359Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 421405Sequence analysisPRO_5007634649Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000128510.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000222482.

Structurei

3D structure databases

SMRiA4D1M3. Positions 18-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 19423Peptidase_M14InterPro annotationAdd
BLAST
Domaini308 – 31811Peptidase_M14InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M14 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
HOVERGENiHBG050815.
KOiK08637.
OMAiIQKHGNF.
OrthoDBiEOG091G0HUI.
PhylomeDBiA4D1M3.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D1M3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWILFIGAL IGSSICGQEK FFGDQVLRIN VRNGDEISKL SQLVNSNNLK
60 70 80 90 100
LNFWKSPSSF NRPVDVLVPS VSLQAFKSFL RSQGLEYAVT IEDLQALLDN
110 120 130 140 150
EDDEMQHNEG QERSSNNFNY GAYHSLEAIY HEMDNIAADF PDLARRVKIG
160 170 180 190 200
HSFENRPMYV LKFSTGKGVR RPAVWLNAGI HSREWISQAT AIWTARKIVS
210 220 230 240 250
DYQRDPAITS ILEKMDIFLL PVANPDGYVY TQTQNRLWRK TRSRNPGSSC
260 270 280 290 300
IGADPNRNWN ASFAGKGASD NPCSEVYHGP HANSEVEVKS VVDFIQKHGN
310 320 330 340 350
FKGFIDLHSY SQLLMYPYGY SVKKAPDAEE LDKVARLAAK ALASVSGTEY
360 370 380 390 400
QVGPTCTTVY PASGSSIDWA YDNGIKFAFT FELRDTGTYG FLLPANQIIP
410 420
TAEETWLGLK TIMEHVRDNL Y
Length:421
Mass (Da):47,351
Last modified:April 3, 2007 - v1
Checksum:i52750CC50B470EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290993 mRNA. Translation: BAF83682.1.
CH236950 Genomic DNA. Translation: EAL24091.1.
CH471070 Genomic DNA. Translation: EAW83752.1.
CH471070 Genomic DNA. Translation: EAW83753.1.
RefSeqiNP_057436.2. NM_016352.3.
UniGeneiHs.93764.

Genome annotation databases

GeneIDi51200.
KEGGihsa:51200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290993 mRNA. Translation: BAF83682.1.
CH236950 Genomic DNA. Translation: EAL24091.1.
CH471070 Genomic DNA. Translation: EAW83752.1.
CH471070 Genomic DNA. Translation: EAW83753.1.
RefSeqiNP_057436.2. NM_016352.3.
UniGeneiHs.93764.

3D structure databases

SMRiA4D1M3. Positions 18-421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000222482.

Protocols and materials databases

DNASUi51200.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51200.
KEGGihsa:51200.

Organism-specific databases

CTDi51200.
PharmGKBiPA26819.

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
HOVERGENiHBG050815.
KOiK08637.
OMAiIQKHGNF.
OrthoDBiEOG091G0HUI.
PhylomeDBiA4D1M3.

Miscellaneous databases

ChiTaRSiCPA4. human.
GenomeRNAii51200.

Gene expression databases

BgeeiENSG00000128510.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4D1M3_HUMAN
AccessioniPrimary (citable) accession number: A4D1M3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.