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Protein

V-type proton ATPase subunit F

Gene

ATP6V1F

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit FUniRule annotation
Gene namesi
Name:ATP6V1FImported
ORF Names:hCG_41657Imported, tcag7.419Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38421.

Expressioni

Gene expression databases

BgeeiENSG00000128524.

Interactioni

Subunit structurei

V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase F subunit family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG004488.
KOiK02151.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiIPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view]
PANTHERiPTHR13861. PTHR13861. 1 hit.
PfamiPF01990. ATP-synt_F. 1 hit.
[Graphical view]
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.

Sequencei

Sequence statusi: Complete.

A4D1K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED
60 70 80 90 100
TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA
110
AKDSILRRAR GMFTAEDLR
Length:119
Mass (Da):13,370
Last modified:April 3, 2007 - v1
Checksum:i9FE5A8BD249A85FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312214 mRNA. Translation: BAG35147.1.
CH236950 Genomic DNA. Translation: EAL24110.1.
CH471070 Genomic DNA. Translation: EAW83692.1.
CH471070 Genomic DNA. Translation: EAW83693.1.
RefSeqiNP_004222.2. NM_004231.3.
UniGeneiHs.78089.

Genome annotation databases

GeneIDi9296.
KEGGihsa:9296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312214 mRNA. Translation: BAG35147.1.
CH236950 Genomic DNA. Translation: EAL24110.1.
CH471070 Genomic DNA. Translation: EAW83692.1.
CH471070 Genomic DNA. Translation: EAW83693.1.
RefSeqiNP_004222.2. NM_004231.3.
UniGeneiHs.78089.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9296.
KEGGihsa:9296.

Organism-specific databases

CTDi9296.
PharmGKBiPA38421.

Phylogenomic databases

HOVERGENiHBG004488.
KOiK02151.

Miscellaneous databases

GenomeRNAii9296.

Gene expression databases

BgeeiENSG00000128524.

Family and domain databases

Gene3Di3.40.50.10580. 1 hit.
InterProiIPR008218. ATPase_V1-cplx_f_g_su.
IPR005772. ATPase_V1-cplx_fsu_euk.
[Graphical view]
PANTHERiPTHR13861. PTHR13861. 1 hit.
PfamiPF01990. ATP-synt_F. 1 hit.
[Graphical view]
PIRSFiPIRSF015945. ATPase_V1_F_euk. 1 hit.
SUPFAMiSSF159468. SSF159468. 1 hit.
TIGRFAMsiTIGR01101. V_ATP_synt_F. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4D1K0_HUMAN
AccessioniPrimary (citable) accession number: A4D1K0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.