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Protein
Submitted name:

Pyruvate dehydrogenase kinase, isoenzyme 4

Gene

PDK4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase
LigandPyruvateImported

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate dehydrogenase kinase, isoenzyme 4Imported
Submitted name:
Pyruvate dehydrogenase kinase, isozyme 4, isoform CRA_aImported
Submitted name:
cDNA, FLJ92766, Homo sapiens pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4), mRNAImported
Gene namesi
Name:PDK4Imported
ORF Names:hCG_38945Imported, tcag7.283Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000004799.7

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33157

Expressioni

Gene expression databases

BgeeiENSG00000004799
ExpressionAtlasiA4D1H4 baseline and differential

Structurei

3D structure databases

SMRiA4D1H4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 368Histidine kinaseInterPro annotationAdd BLAST124

Phylogenomic databases

eggNOGiKOG0787 Eukaryota
COG0642 LUCA
HOVERGENiHBG000511
KOiK00898
OMAiLMNQHIL
OrthoDBiEOG091G07DJ

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.140.20, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR036784 AK/P_DHK_N_sf
IPR018955 BCDHK/PDK_N
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
PfamiView protein in Pfam
PF10436 BCDHK_Adom3, 1 hit
PF02518 HATPase_c, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
SSF69012 SSF69012, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

A4D1H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAARFVLRS AGSLNGAGLV PREVEHFSRY SPSPLSMKQL LDFGSENACE
60 70 80 90 100
RTSFAFLRQE LPVRLANILK EIDILPTQLV NTSSVQLVKS WYIQSLMDLV
110 120 130 140 150
EFHEKSPDDQ KALSDFVDTL IKVRNRHHNV VPTMAQGIIE YKDACTVDPV
160 170 180 190 200
TNQNLQYFLD RFYMNRISTR MLMNQHILIF SDSQTGNPSH IGSIDPNCDV
210 220 230 240 250
VAVVQDAFEC SRMLCDQYYL SSPELKLTQV NGKFPDQPIH IVYVPSHLHH
260 270 280 290 300
MLFELFKNAM RATVEHQENQ PSLTPIEVIV VLGKEDLTIK ISDRGGGVPL
310 320 330 340 350
RIIDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL
360 370 380 390 400
YSLSGYGTDA IIYLKALSSE SIEKLPVFNK SAFKHYQMSS EADDWCIPSR
410
EPKNLAKEVA M
Length:411
Mass (Da):46,469
Last modified:April 3, 2007 - v1
Checksum:iC17B78B6057000E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312424 mRNA Translation: BAG35334.1
CH236949 Genomic DNA Translation: EAL24128.1
CH471091 Genomic DNA Translation: EAW76757.1
CH471091 Genomic DNA Translation: EAW76758.1
RefSeqiNP_002603.1, NM_002612.3
UniGeneiHs.8364

Genome annotation databases

GeneIDi5166
KEGGihsa:5166

Similar proteinsi

Entry informationi

Entry nameiA4D1H4_HUMAN
AccessioniPrimary (citable) accession number: A4D1H4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health