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Protein
Submitted name:

Pyruvate dehydrogenase kinase, isoenzyme 4

Gene

PDK4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

PyruvateImported

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate dehydrogenase kinase, isoenzyme 4Imported
Submitted name:
Pyruvate dehydrogenase kinase, isozyme 4, isoform CRA_aImported
Submitted name:
cDNA, FLJ92766, Homo sapiens pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4), mRNAImported
Gene namesi
Name:PDK4Imported
ORF Names:hCG_38945Imported, tcag7.283Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33157.

Expressioni

Gene expression databases

BgeeiENSG00000004799.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000005178.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 368Histidine kinaseInterPro annotationAdd BLAST124

Phylogenomic databases

eggNOGiKOG0787. Eukaryota.
COG0642. LUCA.
HOVERGENiHBG000511.
KOiK00898.
OMAiPSREPKN.
OrthoDBiEOG091G07DJ.

Family and domain databases

Gene3Di1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
[Graphical view]
PfamiPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D1H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAARFVLRS AGSLNGAGLV PREVEHFSRY SPSPLSMKQL LDFGSENACE
60 70 80 90 100
RTSFAFLRQE LPVRLANILK EIDILPTQLV NTSSVQLVKS WYIQSLMDLV
110 120 130 140 150
EFHEKSPDDQ KALSDFVDTL IKVRNRHHNV VPTMAQGIIE YKDACTVDPV
160 170 180 190 200
TNQNLQYFLD RFYMNRISTR MLMNQHILIF SDSQTGNPSH IGSIDPNCDV
210 220 230 240 250
VAVVQDAFEC SRMLCDQYYL SSPELKLTQV NGKFPDQPIH IVYVPSHLHH
260 270 280 290 300
MLFELFKNAM RATVEHQENQ PSLTPIEVIV VLGKEDLTIK ISDRGGGVPL
310 320 330 340 350
RIIDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL
360 370 380 390 400
YSLSGYGTDA IIYLKALSSE SIEKLPVFNK SAFKHYQMSS EADDWCIPSR
410
EPKNLAKEVA M
Length:411
Mass (Da):46,469
Last modified:April 3, 2007 - v1
Checksum:iC17B78B6057000E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312424 mRNA. Translation: BAG35334.1.
CH236949 Genomic DNA. Translation: EAL24128.1.
CH471091 Genomic DNA. Translation: EAW76757.1.
CH471091 Genomic DNA. Translation: EAW76758.1.
RefSeqiNP_002603.1. NM_002612.3.
UniGeneiHs.8364.

Genome annotation databases

GeneIDi5166.
KEGGihsa:5166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312424 mRNA. Translation: BAG35334.1.
CH236949 Genomic DNA. Translation: EAL24128.1.
CH471091 Genomic DNA. Translation: EAW76757.1.
CH471091 Genomic DNA. Translation: EAW76758.1.
RefSeqiNP_002603.1. NM_002612.3.
UniGeneiHs.8364.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000005178.

Protocols and materials databases

DNASUi5166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5166.
KEGGihsa:5166.

Organism-specific databases

CTDi5166.
PharmGKBiPA33157.

Phylogenomic databases

eggNOGiKOG0787. Eukaryota.
COG0642. LUCA.
HOVERGENiHBG000511.
KOiK00898.
OMAiPSREPKN.
OrthoDBiEOG091G07DJ.

Miscellaneous databases

ChiTaRSiPDK4. human.
GenomeRNAii5166.

Gene expression databases

BgeeiENSG00000004799.

Family and domain databases

Gene3Di1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
[Graphical view]
PfamiPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4D1H4_HUMAN
AccessioniPrimary (citable) accession number: A4D1H4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.