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Protein

GTP-binding protein 10

Gene

GTPBP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi155 – 162GTPPROSITE-ProRule annotation8
Nucleotide bindingi202 – 206GTPPROSITE-ProRule annotation5
Nucleotide bindingi278 – 281GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 10
Alternative name(s):
Protein obg homolog 2
Short name:
ObgH2
Gene namesi
Name:GTPBP10
Synonyms:OBGH2
ORF Names:UG0751c10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:25106. GTPBP10.

Subcellular locationi

  • Nucleusnucleolus 1 Publication
  • Chromosome 1 Publication

  • Note: Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105793.
PharmGKBiPA162390482.

Polymorphism and mutation databases

BioMutaiGTPBP10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126301 – 387GTP-binding protein 10Add BLAST387

Proteomic databases

EPDiA4D1E9.
MaxQBiA4D1E9.
PaxDbiA4D1E9.
PRIDEiA4D1E9.

PTM databases

iPTMnetiA4D1E9.
PhosphoSitePlusiA4D1E9.

Expressioni

Gene expression databases

BgeeiENSG00000105793.
CleanExiHS_GTPBP10.
ExpressionAtlasiA4D1E9. baseline and differential.
GenevisibleiA4D1E9. HS.

Organism-specific databases

HPAiHPA021076.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-5453796,EBI-618309
MTUS2Q5JR593EBI-5453796,EBI-742948
PNMA1Q8ND904EBI-5453796,EBI-302345

Protein-protein interaction databases

BioGridi124573. 18 interactors.
IntActiA4D1E9. 7 interactors.
MINTiMINT-1465319.
STRINGi9606.ENSP00000222511.

Structurei

3D structure databases

ProteinModelPortaliA4D1E9.
SMRiA4D1E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 344OBG-type GPROSITE-ProRule annotationAdd BLAST196

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1489. Eukaryota.
COG0536. LUCA.
GeneTreeiENSGT00530000063429.
HOVERGENiHBG104309.
InParanoidiA4D1E9.
OMAiNLWISDT.
OrthoDBiEOG091G0CXM.
PhylomeDBiA4D1E9.
TreeFamiTF314774.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4D1E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHCSCVLFR KYGNFIDKLR LFTRGGSGGM GYPRLGGEGG KGGDVWVVAQ
60 70 80 90 100
NRMTLKQLKD RYPRKRFVAG VGANSKISAL KGSKGKDCEI PVPVGISVTD
110 120 130 140 150
ENGKIIGELN KENDRILVAQ GGLGGKLLTN FLPLKGQKRI IHLDLKLIAD
160 170 180 190 200
VGLVGFPNAG KSSLLSCVSH AKPAIADYAF TTLKPELGKI MYSDFKQISV
210 220 230 240 250
ADLPGLIEGA HMNKGMGHKF LKHIERTRQL LFVVDISGFQ LSSHTQYRTA
260 270 280 290 300
FETIILLTKE LELYKEELQT KPALLAVNKM DLPDAQDKFH ELMSQLQNPK
310 320 330 340 350
DFLHLFEKNM IPERTVEFQH IIPISAVTGE GIEELKNCIR KSLDEQANQE
360 370 380
NDALHKKQLL NLWISDTMSS TEPPSKHAVT TSKMDII
Length:387
Mass (Da):42,933
Last modified:April 3, 2007 - v1
Checksum:i1A89697B83320075
GO
Isoform 2 (identifier: A4D1E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-155: Missing.

Show »
Length:308
Mass (Da):34,651
Checksum:i2496B9D34CCA3FCB
GO
Isoform 3 (identifier: A4D1E9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-116: GELNKENDRI → DSQMLENPLC
     117-387: Missing.

Show »
Length:116
Mass (Da):12,577
Checksum:iC4DEFBC7A945703E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64R → G in AAI07715 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03754388C → W.3 PublicationsCorresponds to variant rs42663dbSNPEnsembl.1
Natural variantiVAR_037544110N → S.1 PublicationCorresponds to variant rs42664dbSNPEnsembl.1
Natural variantiVAR_037545164L → F.Corresponds to variant rs35001814dbSNPEnsembl.1
Natural variantiVAR_037546368M → I.1 PublicationCorresponds to variant rs17863999dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02988077 – 155Missing in isoform 2. 2 PublicationsAdd BLAST79
Alternative sequenceiVSP_029881107 – 116GELNKENDRI → DSQMLENPLC in isoform 3. 1 Publication10
Alternative sequenceiVSP_029882117 – 387Missing in isoform 3. 1 PublicationAdd BLAST271

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351613 mRNA. Translation: AAN76513.1.
AK095561 mRNA. Translation: BAC04573.1.
AK294325 mRNA. Translation: BAG57597.1.
CR933597 mRNA. Translation: CAI45922.1.
AC002064 Genomic DNA. No translation available.
AC006153 Genomic DNA. Translation: AAD15550.2.
CH236949 Genomic DNA. Translation: EAL24164.1.
CH471091 Genomic DNA. Translation: EAW76880.1.
CH471091 Genomic DNA. Translation: EAW76882.1.
BC004923 mRNA. Translation: AAH04923.3.
BC021573 mRNA. Translation: AAH21573.2.
BC107714 mRNA. Translation: AAI07715.1.
CCDSiCCDS43614.1. [A4D1E9-2]
CCDS5617.1. [A4D1E9-1]
RefSeqiNP_001036182.1. NM_001042717.2. [A4D1E9-2]
NP_149098.2. NM_033107.3. [A4D1E9-1]
UniGeneiHs.593547.
Hs.709271.

Genome annotation databases

EnsembliENST00000222511; ENSP00000222511; ENSG00000105793. [A4D1E9-1]
ENST00000257659; ENSP00000257659; ENSG00000105793. [A4D1E9-2]
ENST00000380058; ENSP00000369398; ENSG00000105793. [A4D1E9-3]
GeneIDi85865.
KEGGihsa:85865.
UCSCiuc003ukm.3. human. [A4D1E9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351613 mRNA. Translation: AAN76513.1.
AK095561 mRNA. Translation: BAC04573.1.
AK294325 mRNA. Translation: BAG57597.1.
CR933597 mRNA. Translation: CAI45922.1.
AC002064 Genomic DNA. No translation available.
AC006153 Genomic DNA. Translation: AAD15550.2.
CH236949 Genomic DNA. Translation: EAL24164.1.
CH471091 Genomic DNA. Translation: EAW76880.1.
CH471091 Genomic DNA. Translation: EAW76882.1.
BC004923 mRNA. Translation: AAH04923.3.
BC021573 mRNA. Translation: AAH21573.2.
BC107714 mRNA. Translation: AAI07715.1.
CCDSiCCDS43614.1. [A4D1E9-2]
CCDS5617.1. [A4D1E9-1]
RefSeqiNP_001036182.1. NM_001042717.2. [A4D1E9-2]
NP_149098.2. NM_033107.3. [A4D1E9-1]
UniGeneiHs.593547.
Hs.709271.

3D structure databases

ProteinModelPortaliA4D1E9.
SMRiA4D1E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124573. 18 interactors.
IntActiA4D1E9. 7 interactors.
MINTiMINT-1465319.
STRINGi9606.ENSP00000222511.

PTM databases

iPTMnetiA4D1E9.
PhosphoSitePlusiA4D1E9.

Polymorphism and mutation databases

BioMutaiGTPBP10.

Proteomic databases

EPDiA4D1E9.
MaxQBiA4D1E9.
PaxDbiA4D1E9.
PRIDEiA4D1E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222511; ENSP00000222511; ENSG00000105793. [A4D1E9-1]
ENST00000257659; ENSP00000257659; ENSG00000105793. [A4D1E9-2]
ENST00000380058; ENSP00000369398; ENSG00000105793. [A4D1E9-3]
GeneIDi85865.
KEGGihsa:85865.
UCSCiuc003ukm.3. human. [A4D1E9-1]

Organism-specific databases

CTDi85865.
GeneCardsiGTPBP10.
HGNCiHGNC:25106. GTPBP10.
HPAiHPA021076.
MIMi610920. gene.
neXtProtiNX_A4D1E9.
OpenTargetsiENSG00000105793.
PharmGKBiPA162390482.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1489. Eukaryota.
COG0536. LUCA.
GeneTreeiENSGT00530000063429.
HOVERGENiHBG104309.
InParanoidiA4D1E9.
OMAiNLWISDT.
OrthoDBiEOG091G0CXM.
PhylomeDBiA4D1E9.
TreeFamiTF314774.

Miscellaneous databases

GenomeRNAii85865.
PROiA4D1E9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105793.
CleanExiHS_GTPBP10.
ExpressionAtlasiA4D1E9. baseline and differential.
GenevisibleiA4D1E9. HS.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTPBA_HUMAN
AccessioniPrimary (citable) accession number: A4D1E9
Secondary accession number(s): B4DFY6
, Q3B7A6, Q5H9V2, Q8IXG8, Q8N982, Q8WU16, Q9BSP1, Q9Y6T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.