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Protein

Zinc finger protein 804B

Gene

ZNF804B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7925C2H2-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 804B
Gene namesi
Name:ZNF804B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21958. ZNF804B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410600.

Polymorphism and mutation databases

BioMutaiZNF804B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13491349Zinc finger protein 804BPRO_0000289140Add
BLAST

Proteomic databases

EPDiA4D1E1.
MaxQBiA4D1E1.
PaxDbiA4D1E1.
PRIDEiA4D1E1.

PTM databases

iPTMnetiA4D1E1.
PhosphoSiteiA4D1E1.

Expressioni

Gene expression databases

BgeeiENSG00000182348.
CleanExiHS_ZNF804B.
ExpressionAtlasiA4D1E1. baseline and differential.
GenevisibleiA4D1E1. HS.

Organism-specific databases

HPAiHPA026702.

Interactioni

Protein-protein interaction databases

BioGridi128555. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA4D1E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 7925C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGPJ. Eukaryota.
ENOG410YAI1. LUCA.
GeneTreeiENSGT00530000063305.
HOGENOMiHOG000155755.
InParanoidiA4D1E1.
OMAiNHRTGVS.
OrthoDBiEOG091G01DY.
PhylomeDBiA4D1E1.
TreeFamiTF332138.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D1E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACYLVISSR HLSNGHYRGI KGVFRGPLCK NGSPSPDFAE KKSTAKALED
60 70 80 90 100
VKANFYCELC DKQYHKHQEF DNHINSYDHA HKQRLKELKQ REFARNVASK
110 120 130 140 150
SWKDEKKQEK ALKRLHQLAE LRQQSECVSG NGPAYKAPRV AIEKQLQQGI
160 170 180 190 200
FPIKNGRKVS CMKSALLLKG KNLPRIISDK QRSTMPNRHQ LQSDRRCLFG
210 220 230 240 250
NQVLQTSSDL SNANHRTGVS FTFSKKVHLK LESSASVFSE NTEETHDCNK
260 270 280 290 300
SPIYKTKQTA DKCKCCRFAN KDTHLTKEKE VNISPSHLES VLHNTISINS
310 320 330 340 350
KILQDKHDSI DETLEDSIGI HASFSKSNIH LSDVDFTPTS REKETRNTLK
360 370 380 390 400
NTLENCVNHP CQANASFSPP NIYNHSDARI SECLDEFSSL EPSEQKSTVH
410 420 430 440 450
LNPNSRIENR EKSLDKTERV SKNVQRLVKE ACTHNVASKP LPFLHVQSKD
460 470 480 490 500
GHTTLQWPTE LLLFTKTEPC ISYGCNPLYF DFKLSRNTKE DHNLEDLKTE
510 520 530 540 550
LGKKPLELKT KRESQVSGLT EDQQKLIQED YQYPKPKTMI ANPDWEKFQR
560 570 580 590 600
KYNLDYSDSE PNKSEYTFSA NDLEMKNPKV PLYLNTSLKD CAGKNNSSEN
610 620 630 640 650
KLKEASRAHW QGCRKAVLND IDEDLSFPSY ISRFKKHKLI PCSPHLEFED
660 670 680 690 700
ERQFNCKSSP CTVGGHSDHG KDFSVILKSN HISMTSKVSG CGNQRYKRYS
710 720 730 740 750
PQSCLSRYSS SLDTSPSSMS SLRSTCSSHR FNGNSRGNLL CFHKREHHSV
760 770 780 790 800
ERHKRKCLKH NCFYLSDDIT KSSQMQSEPQ KERNCKLWES FKNEKYSKRR
810 820 830 840 850
YCHCRERQKL GKNQQQFSGL KSTRIIYCDS NSQISCTGSS KKPPNCQGTQ
860 870 880 890 900
HDRLDSYSIE KMYYLNKSKR NQESLGSPHI CDLGKVRPMK CNSGNISCLL
910 920 930 940 950
KNCSSGPSET TESNTAEGER TPLTAKILLE RVQAKKCQEQ SSNVEISSNS
960 970 980 990 1000
CKSELEAPSQ VPCTIQLAPS GCNRQALPLS EKIQYASESR NDQDSAIPRT
1010 1020 1030 1040 1050
TEKDKSKSSH TNNFTILADT DCDNHLSKGI IHLVTESQSL NIKRDATTKE
1060 1070 1080 1090 1100
QSKPLISEIQ PFIQSCDPVP NEFPGAFPSN KYTGVTDSTE TQEDQINLDL
1110 1120 1130 1140 1150
QDVSMHINHV EGNINSYYDR TMQKPDKVED GLEMCHKSIS PPLIQQPITF
1160 1170 1180 1190 1200
SPDEIDKYKI LQLQAQQHMQ KQLLSKHLRV LPAAGPTAFS PASTVQTVPV
1210 1220 1230 1240 1250
HQHTSITTIH HTFLQHFAVS ASLSSHSSHL PIAHLHPLSQ AHFSPISFST
1260 1270 1280 1290 1300
LTPTIIPAHP TFLAGHPLHL VAATPFHPSH ITLQPLPPTA FIPTLFGPHL
1310 1320 1330 1340
NPATTSIIHL NPLIQPVFQG QDFCHHSCSS QMQQLNEVKE ALNVSTHLN
Length:1,349
Mass (Da):152,573
Last modified:March 24, 2009 - v2
Checksum:i8A5E69A1F0536DFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441K → E in BAB71248 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti248 – 2481C → Y.1 Publication
Corresponds to variant rs1916830 [ dbSNP | Ensembl ].
VAR_054666
Natural varianti634 – 6341F → I.1 Publication
Corresponds to variant rs801840 [ dbSNP | Ensembl ].
VAR_059938
Natural varianti909 – 9091E → K.
Corresponds to variant rs10487075 [ dbSNP | Ensembl ].
VAR_054667
Natural varianti914 – 9141N → H.
Corresponds to variant rs59859857 [ dbSNP | Ensembl ].
VAR_061968
Natural varianti915 – 9151T → I.
Corresponds to variant rs56948780 [ dbSNP | Ensembl ].
VAR_061969
Natural varianti1105 – 11051M → V.
Corresponds to variant rs6963781 [ dbSNP | Ensembl ].
VAR_054668
Natural varianti1195 – 11951V → I.
Corresponds to variant rs801841 [ dbSNP | Ensembl ].
VAR_054669

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY295769 mRNA. Translation: AAP49447.1.
AC002127 Genomic DNA. No translation available.
AC002382 Genomic DNA. No translation available.
AC006350 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24168.1.
BC140826 mRNA. Translation: AAI40827.1.
BC140829 mRNA. Translation: AAI40830.1.
AK056672 mRNA. Translation: BAB71248.1.
CCDSiCCDS5613.1.
RefSeqiNP_857597.1. NM_181646.3.
UniGeneiHs.684410.

Genome annotation databases

EnsembliENST00000333190; ENSP00000329638; ENSG00000182348.
GeneIDi219578.
KEGGihsa:219578.
UCSCiuc011khi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY295769 mRNA. Translation: AAP49447.1.
AC002127 Genomic DNA. No translation available.
AC002382 Genomic DNA. No translation available.
AC006350 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24168.1.
BC140826 mRNA. Translation: AAI40827.1.
BC140829 mRNA. Translation: AAI40830.1.
AK056672 mRNA. Translation: BAB71248.1.
CCDSiCCDS5613.1.
RefSeqiNP_857597.1. NM_181646.3.
UniGeneiHs.684410.

3D structure databases

ProteinModelPortaliA4D1E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128555. 1 interaction.

PTM databases

iPTMnetiA4D1E1.
PhosphoSiteiA4D1E1.

Polymorphism and mutation databases

BioMutaiZNF804B.

Proteomic databases

EPDiA4D1E1.
MaxQBiA4D1E1.
PaxDbiA4D1E1.
PRIDEiA4D1E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333190; ENSP00000329638; ENSG00000182348.
GeneIDi219578.
KEGGihsa:219578.
UCSCiuc011khi.3. human.

Organism-specific databases

CTDi219578.
GeneCardsiZNF804B.
HGNCiHGNC:21958. ZNF804B.
HPAiHPA026702.
neXtProtiNX_A4D1E1.
PharmGKBiPA162410600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPJ. Eukaryota.
ENOG410YAI1. LUCA.
GeneTreeiENSGT00530000063305.
HOGENOMiHOG000155755.
InParanoidiA4D1E1.
OMAiNHRTGVS.
OrthoDBiEOG091G01DY.
PhylomeDBiA4D1E1.
TreeFamiTF332138.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF804B. human.
GenomeRNAii219578.
PROiA4D1E1.

Gene expression databases

BgeeiENSG00000182348.
CleanExiHS_ZNF804B.
ExpressionAtlasiA4D1E1. baseline and differential.
GenevisibleiA4D1E1. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR022755. Znf_C2H2_jaz.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ804B_HUMAN
AccessioniPrimary (citable) accession number: A4D1E1
Secondary accession number(s): B2RTV2, Q7Z714, Q96MN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 24, 2009
Last modified: September 7, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.