Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Gene

ABCB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette, sub-family B (MDR/TAP), member 1Imported
Submitted name:
ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_cImported
Submitted name:
Multidrug resistance protein 1Imported
Gene namesi
Name:ABCB1Imported
ORF Names:hCG_20818Imported, tcag7.316Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 72HelicalSequence analysisAdd BLAST24
Transmembranei115 – 139HelicalSequence analysisAdd BLAST25
Transmembranei190 – 208HelicalSequence analysisAdd BLAST19
Transmembranei214 – 233HelicalSequence analysisAdd BLAST20
Transmembranei293 – 316HelicalSequence analysisAdd BLAST24
Transmembranei708 – 733HelicalSequence analysisAdd BLAST26
Transmembranei753 – 777HelicalSequence analysisAdd BLAST25
Transmembranei859 – 879HelicalSequence analysisAdd BLAST21
Transmembranei935 – 954HelicalSequence analysisAdd BLAST20
Transmembranei974 – 995HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA267.

Expressioni

Gene expression databases

BgeeiENSG00000085563.
ExpressionAtlasiA4D1D2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265724.

Structurei

3D structure databases

SMRiA4D1D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 357ABC transmembrane type-1InterPro annotationAdd BLAST306
Domaini392 – 628ABC transporterInterPro annotationAdd BLAST237
Domaini712 – 1000ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini1035 – 1273ABC transporterInterPro annotationAdd BLAST239

Sequence similaritiesi

Contains 2 ABC transporter domains.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG080809.
KOiK05658.
OMAiSQGQDRK.
OrthoDBiEOG091G0HVA.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D1D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY
60 70 80 90 100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND
110 120 130 140 150
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ
160 170 180 190 200
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF
210 220 230 240 250
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA
260 270 280 290 300
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
310 320 330 340 350
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP
360 370 380 390 400
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS
410 420 430 440 450
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM
460 470 480 490 500
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI
510 520 530 540 550
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK
560 570 580 590 600
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG
610 620 630 640 650
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA
660 670 680 690 700
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI
710 720 730 740 750
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ
760 770 780 790 800
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD
810 820 830 840 850
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS
860 870 880 890 900
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA
910 920 930 940 950
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY
960 970 980 990 1000
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK
1010 1020 1030 1040 1050
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI
1060 1070 1080 1090 1100
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE
1110 1120 1130 1140 1150
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK
1160 1170 1180 1190 1200
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD
1210 1220 1230 1240 1250
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR
1260 1270 1280
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ
Length:1,280
Mass (Da):141,479
Last modified:April 3, 2007 - v1
Checksum:iF0230744AB288C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU852583 mRNA. Translation: ACF94687.1.
CH236949 Genomic DNA. Translation: EAL24173.1.
CH471091 Genomic DNA. Translation: EAW76942.1.
RefSeqiNP_000918.2. NM_000927.4.
UniGeneiHs.489033.
Hs.689936.
Hs.737655.

Genome annotation databases

GeneIDi5243.
KEGGihsa:5243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU852583 mRNA. Translation: ACF94687.1.
CH236949 Genomic DNA. Translation: EAL24173.1.
CH471091 Genomic DNA. Translation: EAW76942.1.
RefSeqiNP_000918.2. NM_000927.4.
UniGeneiHs.489033.
Hs.689936.
Hs.737655.

3D structure databases

SMRiA4D1D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265724.

Protocols and materials databases

DNASUi5243.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5243.
KEGGihsa:5243.

Organism-specific databases

CTDi5243.
PharmGKBiPA267.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG080809.
KOiK05658.
OMAiSQGQDRK.
OrthoDBiEOG091G0HVA.

Miscellaneous databases

ChiTaRSiABCB1. human.
GenomeRNAii5243.

Gene expression databases

BgeeiENSG00000085563.
ExpressionAtlasiA4D1D2. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4D1D2_HUMAN
AccessioniPrimary (citable) accession number: A4D1D2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.