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Protein
Submitted name:

Glutamate metabotropic receptor 3

Gene

GRM3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate metabotropic receptor 3Imported
Submitted name:
Glutamate receptor, metabotropic 3Imported
Submitted name:
Glutamate receptor, metabotropic 3, isoform CRA_bImported
Gene namesi
Name:GRM3Imported
ORF Names:hCG_17203Imported, tcag7.244Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000198822.10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei575 – 599HelicalSequence analysisAdd BLAST25
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Transmembranei688 – 709HelicalSequence analysisAdd BLAST22
Transmembranei737 – 756HelicalSequence analysisAdd BLAST20
Transmembranei768 – 790HelicalSequence analysisAdd BLAST23
Transmembranei796 – 820HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501010281625 – 879Sequence analysisAdd BLAST855

Expressioni

Gene expression databases

BgeeiENSG00000198822.
ExpressionAtlasiA4D1D0. baseline and differential.

Structurei

3D structure databases

SMRiA4D1D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini576 – 842G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
HOVERGENiHBG107965.
KOiK04605.
OMAiTYVPTVC.
OrthoDBiEOG091G177R.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001234. GPCR_3_mtglu_rcpt_3.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
PR01053. MTABOTROPC3R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

A4D1D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK
60 70 80 90 100
GTGTEECGRI NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS
110 120 130 140 150
RDTYALEQSL EFVRASLTKV DEAEYMCPDG SYAIQENIPL LIAGVIGGSY
160 170 180 190 200
SSVSIQVANL LRLFQIPQIS YASTSAKLSD KSRYDYFART VPPDFYQAKA
210 220 230 240 250
MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC IATAEKVGRS
260 270 280 290 300
NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS
310 320 330 340 350
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW
360 370 380 390 400
FRDFWEQKFQ CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM
410 420 430 440 450
AHALHKMQRT LCPNTTKLCD AMKILDGKKL YKDYLLKINF TAPFNPNKDA
460 470 480 490 500
DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY LKVGHWAETL SLDVNSIHWS
510 520 530 540 550
RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL ADEFTCMDCG
560 570 580 590 600
SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK
610 620 630 640 650
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS
660 670 680 690 700
SFAICYSALL TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI
710 720 730 740 750
VMVSVWLILE APGTRRYTLA EKRETVILKC NVKDSSMLIS LTYDVILVIL
760 770 780 790 800
CTVYAFKTRK CPENFNEAKF IGFTMYTTCI IWLAFLPIFY VTSSDYRVQT
810 820 830 840 850
TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH LNRFSVSGTG
860 870
TTYSQSSAST YVPTVCNGRE VLDSTTSSL
Length:879
Mass (Da):98,879
Last modified:April 3, 2007 - v1
Checksum:i7EB84521676E8304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU432123 mRNA. Translation: ABY87922.1.
CH236949 Genomic DNA. Translation: EAL24182.1.
CH471091 Genomic DNA. Translation: EAW76972.1.
RefSeqiNP_000831.2. NM_000840.2.
UniGeneiHs.590575.

Genome annotation databases

GeneIDi2913.
KEGGihsa:2913.

Similar proteinsi

Entry informationi

Entry nameiA4D1D0_HUMAN
AccessioniPrimary (citable) accession number: A4D1D0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 27, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.