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Protein
Submitted name:

Fibrinogen-like 2

Gene

FGL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Fibrinogen-like 2Imported
Submitted name:
cDNA, FLJ93065, Homo sapiens fibrinogen-like 2 (FGL2), mRNAImported
Gene namesi
Name:FGL2Imported
ORF Names:hCG_39113Imported, tcag7.1277Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501010280824 – 439Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi213 ↔ 242PROSITE-ProRule annotation
Disulfide bondi371 ↔ 384PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000127951.
ExpressionAtlasiA4D1B8. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 436Fibrinogen C-terminalInterPro annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 102Sequence analysisAdd BLAST28
Coiled coili130 – 164Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOVERGENiHBG105002.
OMAiFYVANEF.
OrthoDBiEOG091G03M1.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiView protein in InterPro
IPR033083. Fgl2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
PANTHERiPTHR19143:SF277. PTHR19143:SF277. 1 hit.
PfamiView protein in Pfam
PF00147. Fibrinogen_C. 1 hit.
SMARTiView protein in SMART
SM00186. FBG. 1 hit.
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiView protein in PROSITE
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4D1B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE
60 70 80 90 100
EAGECPYQVS LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK
110 120 130 140 150
LQADDNGDPG RNGLLLPSTG APGEVGDNRV RELESEVNKL SSELKNAKEE
160 170 180 190 200
INVLHGRLEK LNLVNMNNIE NYVDSKVANL TFVVNSLDGK CSKCPSQEQI
210 220 230 240 250
QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV YCDMETMGGG
260 270 280 290 300
WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL
310 320 330 340 350
RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN
360 370 380 390 400
HDLKFFTTPD KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG
410 420 430
VRNGIFWGTW PGVSEAHPGG YKSSFKEAKM MIRPKHFKP
Length:439
Mass (Da):50,229
Last modified:April 3, 2007 - v1
Checksum:iDF34656288E49E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312672 mRNA. Translation: BAG35554.1.
CH236949 Genomic DNA. Translation: EAL24202.1.
CH471091 Genomic DNA. Translation: EAW77045.1.
RefSeqiNP_006673.1. NM_006682.2.
UniGeneiHs.520989.

Genome annotation databases

GeneIDi10875.
KEGGihsa:10875.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA4D1B8_HUMAN
AccessioniPrimary (citable) accession number: A4D1B8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 5, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.