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Protein
Submitted name:

Mesenchyme homeo box 2 (Growth arrest-specific homeo box)

Gene

MEOX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Mesenchyme homeo box 2 (Growth arrest-specific homeo box)Imported
Gene namesi
Name:MEOX2Imported
ORF Names:tcag7.130Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiA4D127.

Expressioni

Gene expression databases

BgeeiENSG00000106511.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q6ZVW33EBI-10172134,EBI-10255586
Q7Z7833EBI-10172134,EBI-9088990
Q9NWJ23EBI-10172134,EBI-10315029
ADAMTS12P583973EBI-10172134,EBI-9028051
AGPAT1Q999433EBI-10172134,EBI-3893468
AHCYL1O438653EBI-10172134,EBI-2371423
AHSA2Q719I03EBI-10172134,EBI-9361704
ANP32BQ926883EBI-10172134,EBI-762428
ARD1AQ6P4J03EBI-10172134,EBI-10252815
ARHGEF7Q141553EBI-10172134,EBI-717515
ATG5A9UGY93EBI-10172134,EBI-10175276
BCL2L15Q5TBC73EBI-10172134,EBI-10247136
C1orf109Q9NX045EBI-10172134,EBI-8643161
CARD9Q9H2573EBI-10172134,EBI-751319
CASP14P319443EBI-10172134,EBI-2510738
CCDC103Q8IW405EBI-10172134,EBI-10261970
CCNCP248635EBI-10172134,EBI-395261
CEP57L1Q8IYX8-23EBI-10172134,EBI-10181988
CHIC2Q9UKJ55EBI-10172134,EBI-741528
CHRDQ9H2X05EBI-10172134,EBI-947551
CIAPIN1Q6FI813EBI-10172134,EBI-750511
CIB3Q96Q775EBI-10172134,EBI-10292696
CNTNAP2Q9UHC63EBI-10172134,EBI-310892
CPNE6O957413EBI-10172134,EBI-719005
CPSF4O956393EBI-10172134,EBI-725860
CRCT1Q9UGL93EBI-10172134,EBI-713677
CSDC2Q9Y5343EBI-10172134,EBI-1763657
CSF2P041413EBI-10172134,EBI-1809826
CTNNBL1Q8WYA63EBI-10172134,EBI-748128
CXXC1Q9P0U43EBI-10172134,EBI-949911
DGCR8Q8WYQ53EBI-10172134,EBI-528411
DOCK8Q8NF503EBI-10172134,EBI-2548605
DYNLL2Q96FJ23EBI-10172134,EBI-742371
EDF1O608693EBI-10172134,EBI-781301
EFEMP2O959673EBI-10172134,EBI-743414
EFNA3P527973EBI-10172134,EBI-722730
EIF1ADQ8N9N83EBI-10172134,EBI-750700
EIF5AP632415EBI-10172134,EBI-373150
EPM2AIP1Q7L7755EBI-10172134,EBI-6255981
ESRRGP625083EBI-10172134,EBI-2834260
FAM13CQ8NE313EBI-10172134,EBI-751248
FAM3AQ9BU273EBI-10172134,EBI-10298603
FAM74A6Q5TZK35EBI-10172134,EBI-10247271
FBF1Q8TES7-63EBI-10172134,EBI-10244131
FOXR1Q6PIV23EBI-10172134,EBI-10253815
FUCA2Q9BTY23EBI-10172134,EBI-9050116
FUT11Q495W53EBI-10172134,EBI-2907712
GAGE1Q130653EBI-10172134,EBI-10227730
GMCL1P1Q8NEA95EBI-10172134,EBI-745707
GMPR2Q6PKC03EBI-10172134,EBI-10254128
GNG11Q53Y013EBI-10172134,EBI-10243023
GOLGA8DPQ0D2H95EBI-10172134,EBI-10181276
GOLGA8GQ08AF83EBI-10172134,EBI-10181260
GPATCH2LQ9NWQ43EBI-10172134,EBI-5666657
GPSM3Q9Y4H43EBI-10172134,EBI-347538
HAT1O149295EBI-10172134,EBI-2339359
HAT1O14929-23EBI-10172134,EBI-10181798
HDHD2Q9H0R43EBI-10172134,EBI-10304657
HEXIM2Q96MH25EBI-10172134,EBI-5460660
HGFP142103EBI-10172134,EBI-1039104
HP1BP3Q5SSJ53EBI-10172134,EBI-2880687
HTR1EP285663EBI-10172134,EBI-1043151
IGFN1Q86VF23EBI-10172134,EBI-10259767
IP6K2Q9UHH93EBI-10172134,EBI-747509
ITM2AO437363EBI-10172134,EBI-2431769
KAT5Q929933EBI-10172134,EBI-399080
KIZQ2M2Z53EBI-10172134,EBI-2554344
KLC4Q9NSK03EBI-10172134,EBI-949319
KLHL38Q2WGJ63EBI-10172134,EBI-6426443
KRT80Q6KB663EBI-10172134,EBI-3046635
KRT86O437903EBI-10172134,EBI-9996498
KRTAP10-11P604125EBI-10172134,EBI-10217483
KRTAP10-5P603705EBI-10172134,EBI-10172150
KRTAP10-8P604105EBI-10172134,EBI-10171774
KRTAP10-9P604116EBI-10172134,EBI-10172052
KRTAP12-1P599905EBI-10172134,EBI-10210845
KRTAP12-4P603295EBI-10172134,EBI-10176396
KRTAP4-11Q9BYQ65EBI-10172134,EBI-10302392
KRTAP4-2Q9BYR55EBI-10172134,EBI-10172511
KRTAP4-7Q9BYR03EBI-10172134,EBI-10302547
KRTAP5-6Q6L8G95EBI-10172134,EBI-10250562
KRTAP5-9P263715EBI-10172134,EBI-3958099
KRTAP9-2Q9BYQ45EBI-10172134,EBI-1044640
KTN1Q86UP23EBI-10172134,EBI-359761
LAMTOR5A0A0C4DGV43EBI-10172134,EBI-10173304
LCE1BQ5T7P33EBI-10172134,EBI-10245913
LCE2AQ5TA795EBI-10172134,EBI-10246607
LCE4AQ5TA783EBI-10172134,EBI-10246358
LSM2Q9Y3333EBI-10172134,EBI-347416
MAGED1Q9Y5V33EBI-10172134,EBI-716006
MAPKBP1O603365EBI-10172134,EBI-947402
MKRN3Q6NSB63EBI-10172134,EBI-10195599
MLLT6Q6P2C63EBI-10172134,EBI-5773143
MMP3P082543EBI-10172134,EBI-6957351
MORN3Q6PF183EBI-10172134,EBI-9675802
MRFAP1L1Q96HT83EBI-10172134,EBI-748896
MSI2Q96DH63EBI-10172134,EBI-2462339
MT1DPA1L3X45EBI-10172134,EBI-10172129
MUM1Q9H6H23EBI-10172134,EBI-10307610
NAA10P412275EBI-10172134,EBI-747693
NALCNQ8IZF03EBI-10172134,EBI-7085333
NCALDP616013EBI-10172134,EBI-749635
NCK2O436393EBI-10172134,EBI-713635
NTF3P207833EBI-10172134,EBI-1025994
OIT3Q8WWZ85EBI-10172134,EBI-10277776
OSGIN1Q9UJX03EBI-10172134,EBI-9057006
P4HA3Q7Z4N83EBI-10172134,EBI-10181968
PACSIN2Q9UNF05EBI-10172134,EBI-742503
PAGE2Q7Z2X73EBI-10172134,EBI-10256818
PARVGQ9HBI05EBI-10172134,EBI-3921217
PCSK5Q928243EBI-10172134,EBI-751290
PGBD1Q96JS33EBI-10172134,EBI-10290053
PIN1Q135265EBI-10172134,EBI-714158
PKIGQ549H93EBI-10172134,EBI-10243311
POM121CA1L4L93EBI-10172134,EBI-10172978
PRKAB2O437413EBI-10172134,EBI-1053424
PRR19A6NJB73EBI-10172134,EBI-10174045
PSMB10P403063EBI-10172134,EBI-603329
PSMC1P621913EBI-10172134,EBI-357598
PSMC1Q53XL83EBI-10172134,EBI-10242995
PSMD14O004873EBI-10172134,EBI-722193
PTGER3Q147X83EBI-10172134,EBI-10234038
RARBP10826-23EBI-10172134,EBI-8583223
RCHY1Q96PM53EBI-10172134,EBI-947779
RECKQ6P9E25EBI-10172134,EBI-10253121
RHOJQ9H4E53EBI-10172134,EBI-6285694
RMND5AQ9H8713EBI-10172134,EBI-2797992
RPL15P613135EBI-10172134,EBI-443462
RUNX1T1Q06455-43EBI-10172134,EBI-10224192
RYDENQ9NUL53EBI-10172134,EBI-10313866
SCNM1Q9BWG63EBI-10172134,EBI-748391
SETQ011053EBI-10172134,EBI-1053182
SIRPB1O00241-23EBI-10172134,EBI-10179231
SLC48A1Q6P1K13EBI-10172134,EBI-1222191
SMAD3P840223EBI-10172134,EBI-347161
SMARCE1Q969G35EBI-10172134,EBI-455078
SPP1P104513EBI-10172134,EBI-723648
SPRY1O436095EBI-10172134,EBI-3866665
SPRY2O435973EBI-10172134,EBI-742487
SSX3Q999093EBI-10172134,EBI-10295431
STK16O757163EBI-10172134,EBI-749295
STX11O755583EBI-10172134,EBI-714135
STX16O146623EBI-10172134,EBI-2853548
SYT17Q9BSW75EBI-10172134,EBI-745392
TBCELQ5QJ743EBI-10172134,EBI-10244795
TCEA2Q155605EBI-10172134,EBI-710310
TCL6A0A024R6G03EBI-10172134,EBI-10173366
TCTEX1D1Q8N7M03EBI-10172134,EBI-10267606
TGFB1P011373EBI-10172134,EBI-779636
TICAM2Q86XR73EBI-10172134,EBI-525927
TMEM100Q9NV293EBI-10172134,EBI-8644968
TP53BP1Q128883EBI-10172134,EBI-396540
TRAF6Q9Y4K33EBI-10172134,EBI-359276
TRIM41Q8WV445EBI-10172134,EBI-725997
TRIM42Q8IWZ55EBI-10172134,EBI-5235829
TTC25Q96NG33EBI-10172134,EBI-1046387
TTC39BQ5VTQ0-43EBI-10172134,EBI-10247626
TTC9CQ8N5M45EBI-10172134,EBI-2851213
TXLNAP402223EBI-10172134,EBI-359793
UBL4AP114413EBI-10172134,EBI-356983
UBL4BQ8N7F73EBI-10172134,EBI-10267507
UNC45AQ9H3U15EBI-10172134,EBI-1048763
USE1Q9NZ433EBI-10172134,EBI-742842
WFDC9Q8NEX53EBI-10172134,EBI-10270812
XRCC2O435433EBI-10172134,EBI-3918457
ZBED4O751323EBI-10172134,EBI-2860059
ZMAT2Q96NC03EBI-10172134,EBI-2682299
ZNF124Q159735EBI-10172134,EBI-2555767
ZNF329Q86UD43EBI-10172134,EBI-7233259
ZNF404Q494X33EBI-10172134,EBI-10241626
ZNF417Q8TAU35EBI-10172134,EBI-740727
ZNF483Q6P0883EBI-10172134,EBI-10196963
ZNF564Q8TBZ83EBI-10172134,EBI-10273713
ZNF572Q7Z3I73EBI-10172134,EBI-10257016
ZNF587Q96SQ55EBI-10172134,EBI-6427977
ZNF695Q8IW363EBI-10172134,EBI-10261951

Protein-protein interaction databases

IntActiA4D127. 619 interactors.
STRINGi9606.ENSP00000262041.

Structurei

3D structure databases

ProteinModelPortaliA4D127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 244Homeobox DNA-bindingInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOVERGENiHBG052456.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4D127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII
60 70 80 90 100
AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQTN WHLPQMSSPP
110 120 130 140 150
SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPGDYGR
160 170 180 190 200
QALSPAEAEK RSGGKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE
210 220 230 240 250
LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG
260 270 280 290 300
AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSIANED SHDSDHSSEH

AHL
Length:303
Mass (Da):33,457
Last modified:April 3, 2007 - v1
Checksum:i809ADE0CD090023D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA. Translation: EAL24289.1.
UniGeneiHs.170355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236948 Genomic DNA. Translation: EAL24289.1.
UniGeneiHs.170355.

3D structure databases

ProteinModelPortaliA4D127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA4D127. 619 interactors.
STRINGi9606.ENSP00000262041.

Proteomic databases

PaxDbiA4D127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOVERGENiHBG052456.

Miscellaneous databases

ChiTaRSiMEOX2. human.

Gene expression databases

BgeeiENSG00000106511.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4D127_HUMAN
AccessioniPrimary (citable) accession number: A4D127
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 15, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.