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Protein
Submitted name:

Potassium voltage-gated channel, Shal-related subfamily, member 2

Gene

KCND2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel, Shal-related subfamily, member 2Imported
Gene namesi
Name:KCND2Imported
ORF Names:hCG_2039708Imported, tcag7.101Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei183 – 204HelicalSequence analysisAdd BLAST22
Transmembranei224 – 245HelicalSequence analysisAdd BLAST22
Transmembranei257 – 279HelicalSequence analysisAdd BLAST23
Transmembranei324 – 345HelicalSequence analysisAdd BLAST22
Transmembranei357 – 373HelicalSequence analysisAdd BLAST17
Transmembranei385 – 406HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500875444617 – 630Sequence analysisAdd BLAST614

Expressioni

Gene expression databases

BgeeiENSG00000184408.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333496.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 140BTB (POZ)InterPro annotationAdd BLAST100

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4390. Eukaryota.
COG1226. LUCA.
HOVERGENiHBG106687.
KOiK04892.
OMAiNYTSANQ.
OrthoDBiEOG091G18X0.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004055. K_chnl_volt-dep_Kv4.2.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01517. KV42CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

A4D0V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGVAAWLP FARAAAIGWM PVASGPMPAP PRQERKRTQD ALIVLNVSGT
60 70 80 90 100
RFQTWQDTLE RYPDTLLGSS ERDFFYHPET QQYFFDRDPD IFRHILNFYR
110 120 130 140 150
TGKLHYPRHE CISAYDEELA FFGLIPEIIG DCCYEEYKDR RRENAERLQD
160 170 180 190 200
DADTDTAGES ALPTMTARQR VWRAFENPHT STMALVFYYV TGFFIAVSVI
210 220 230 240 250
ANVVETVPCG SSPGHIKELP CGERYAVAFF CLDTACVMIF TVEYLLRLAA
260 270 280 290 300
APSRYRFVRS VMSIIDVVAI LPYYIGLVMT DNEDVSGAFV TLRVFRVFRI
310 320 330 340 350
FKFSRHSQGL RILGYTLKSC ASELGFLLFS LTMAIIIFAT VMFYAEKGSS
360 370 380 390 400
ASKFTSIPAA FWYTIVTMTT LGYGDMVPKT IAGKIFGSIC SLSGVLVIAL
410 420 430 440 450
PVPVIVSNFS RIYHQNQRAD KRRAQKKARL ARIRAAKSGS ANAYMQSKRN
460 470 480 490 500
GLLSNQLQSS EDEQAFVSKS GSSFETQHHH LLHCLEKTTN HEFVDEQVFE
510 520 530 540 550
ESCMEVATVN RPSSHSPSLS SQQGVTSTCC SRRHKKTFRI PNANVSGSHQ
560 570 580 590 600
GSIQELSTIQ IRCVERTPLS NSRSSLNAKM EECVKLNCEQ PYVTTAIISI
610 620 630
PTPPVTTPEG DDRPESPEYS GGNIVRVSAL
Length:630
Mass (Da):70,537
Last modified:April 3, 2007 - v1
Checksum:i0C11E62FFA220421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24350.1.
CH471070 Genomic DNA. Translation: EAW83541.1.
RefSeqiNP_036413.1. NM_012281.2.
UniGeneiHs.654739.

Genome annotation databases

GeneIDi3751.
KEGGihsa:3751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA. Translation: EAL24350.1.
CH471070 Genomic DNA. Translation: EAW83541.1.
RefSeqiNP_036413.1. NM_012281.2.
UniGeneiHs.654739.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3751.
KEGGihsa:3751.

Organism-specific databases

CTDi3751.
PharmGKBiPA30030.

Phylogenomic databases

eggNOGiKOG4390. Eukaryota.
COG1226. LUCA.
HOVERGENiHBG106687.
KOiK04892.
OMAiNYTSANQ.
OrthoDBiEOG091G18X0.

Miscellaneous databases

ChiTaRSiKCND2. human.
GenomeRNAii3751.

Gene expression databases

BgeeiENSG00000184408.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003975. K_chnl_volt-dep_Kv4.
IPR004055. K_chnl_volt-dep_Kv4.2.
IPR024587. K_chnl_volt-dep_Kv4_C.
IPR021645. Shal-type_N.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF11879. DUF3399. 1 hit.
PF00520. Ion_trans. 1 hit.
PF11601. Shal-type. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01517. KV42CHANNEL.
PR01491. KVCHANNEL.
PR01497. SHALCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA4D0V9_HUMAN
AccessioniPrimary (citable) accession number: A4D0V9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.