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Protein

Cadherin-like and PC-esterase domain-containing protein 1

Gene

CPED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-like and PC-esterase domain-containing protein 1
Gene namesi
Name:CPED1
Synonyms:C7orf58
ORF Names:UNQ9432/PRO34713
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:26159. CPED1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi79974.
OpenTargetsiENSG00000106034.
PharmGKBiPA162380636.

Polymorphism and mutation databases

BioMutaiCPED1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000031773235 – 1026Cadherin-like and PC-esterase domain-containing protein 1Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Glycosylationi404N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1
Glycosylationi737N-linked (GlcNAc...)Sequence analysis1
Glycosylationi791N-linked (GlcNAc...)Sequence analysis1
Glycosylationi985N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA4D0V7.
PaxDbiA4D0V7.
PRIDEiA4D0V7.

PTM databases

iPTMnetiA4D0V7.
PhosphoSitePlusiA4D0V7.

Expressioni

Gene expression databases

BgeeiENSG00000106034.
CleanExiHS_C7orf58.
ExpressionAtlasiA4D0V7. baseline and differential.
GenevisibleiA4D0V7. HS.

Organism-specific databases

HPAiHPA012058.

Interactioni

Protein-protein interaction databases

BioGridi123041. 1 interactor.
IntActiA4D0V7. 1 interactor.
MINTiMINT-4722683.
STRINGi9606.ENSP00000309772.

Structurei

3D structure databases

ProteinModelPortaliA4D0V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PC-esterase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEF4. Eukaryota.
ENOG4110TQ2. LUCA.
GeneTreeiENSGT00390000015216.
HOVERGENiHBG095603.
InParanoidiA4D0V7.
OMAiVQDCGLL.
OrthoDBiEOG091G08E5.
PhylomeDBiA4D0V7.
TreeFamiTF332741.

Family and domain databases

InterProiIPR025883. Cadherin-like_b_sandwich.
[Graphical view]
PfamiPF12733. Cadherin-like. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A4D0V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP
60 70 80 90 100
HTSTETQASR CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI
110 120 130 140 150
LYRPPFYSKT ELQLHQHILT QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW
160 170 180 190 200
DLLICLSSKK AEGTPCISKE VMCQLGLHQK ANRLPEIQQP LCRKEGLCQI
210 220 230 240 250
VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW KPGDWSREQL
260 270 280 290 300
NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
310 320 330 340 350
KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK
360 370 380 390 400
TFHRCRFCFQ LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE
410 420 430 440 450
FLLNDTFNFL FPNESSLSIF SEIFQRLYRS DVFKGENYQK ELNQCLSLEE
460 470 480 490 500
INSIMTFIKE LGSLGQFQLL FPSTTPGIQS LMHEFYDVAN PVGNPGSVLT
510 520 530 540 550
QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV PFDAIENKKA
560 570 580 590 600
AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
610 620 630 640 650
PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES
660 670 680 690 700
PAHGETLITY KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ
710 720 730 740 750
PISSDYIEAI LQSELKRCPS GDMKGQWIVP CLSCSDNRTC DWREITWQPH
760 770 780 790 800
NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR GIMYYLIERL NETLQEWQKV
810 820 830 840 850
HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH LLQRSRPLEN
860 870 880 890 900
TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
910 920 930 940 950
GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC
960 970 980 990 1000
GCHFHEVVKS KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP
1010 1020
YHVRGPINQV CSEILLSRMC ANKRTM
Length:1,026
Mass (Da):117,491
Last modified:April 3, 2007 - v1
Checksum:i7C3E91FAF7494440
GO
Isoform 2 (identifier: A4D0V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-783: ILFIGDSTNRGIM → LGVDVQRVPRSRN
     784-1026: Missing.

Note: No experimental confirmation available.
Show »
Length:783
Mass (Da):89,175
Checksum:i3BE8B0AA01D1FB0B
GO

Sequence cautioni

The sequence AAH30538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173C → R in CAD89961 (PubMed:17974005).Curated1
Sequence conflicti186E → G in BAF82667 (PubMed:14702039).Curated1
Sequence conflicti262I → T in CAD89961 (PubMed:17974005).Curated1
Sequence conflicti641K → R in CAD89961 (PubMed:17974005).Curated1
Sequence conflicti795Q → R in CAD89961 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038664326I → T.Corresponds to variant rs17143165dbSNPEnsembl.1
Natural variantiVAR_038665551A → G.3 PublicationsCorresponds to variant rs41281692dbSNPEnsembl.1
Natural variantiVAR_038666708E → G.2 PublicationsCorresponds to variant rs35793694dbSNPEnsembl.1
Natural variantiVAR_038667949K → T.Corresponds to variant rs798911dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031140771 – 783ILFIG…NRGIM → LGVDVQRVPRSRN in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_031141784 – 1026Missing in isoform 2. 2 PublicationsAdd BLAST243

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358220 mRNA. Translation: AAQ88587.1.
AK055624 mRNA. Translation: BAB70974.1.
AK289978 mRNA. Translation: BAF82667.1.
AL832619 mRNA. Translation: CAD89961.1.
AL832638 mRNA. Translation: CAD89953.1.
CH236947 Genomic DNA. Translation: EAL24348.1.
BC030538 mRNA. Translation: AAH30538.1. Different initiation.
CCDSiCCDS34739.1. [A4D0V7-1]
CCDS47690.1. [A4D0V7-2]
RefSeqiNP_001099003.1. NM_001105533.1. [A4D0V7-2]
NP_079189.4. NM_024913.4. [A4D0V7-1]
UniGeneiHs.189652.

Genome annotation databases

EnsembliENST00000310396; ENSP00000309772; ENSG00000106034. [A4D0V7-1]
ENST00000450913; ENSP00000406122; ENSG00000106034. [A4D0V7-2]
GeneIDi79974.
KEGGihsa:79974.
UCSCiuc003vjq.5. human. [A4D0V7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358220 mRNA. Translation: AAQ88587.1.
AK055624 mRNA. Translation: BAB70974.1.
AK289978 mRNA. Translation: BAF82667.1.
AL832619 mRNA. Translation: CAD89961.1.
AL832638 mRNA. Translation: CAD89953.1.
CH236947 Genomic DNA. Translation: EAL24348.1.
BC030538 mRNA. Translation: AAH30538.1. Different initiation.
CCDSiCCDS34739.1. [A4D0V7-1]
CCDS47690.1. [A4D0V7-2]
RefSeqiNP_001099003.1. NM_001105533.1. [A4D0V7-2]
NP_079189.4. NM_024913.4. [A4D0V7-1]
UniGeneiHs.189652.

3D structure databases

ProteinModelPortaliA4D0V7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123041. 1 interactor.
IntActiA4D0V7. 1 interactor.
MINTiMINT-4722683.
STRINGi9606.ENSP00000309772.

PTM databases

iPTMnetiA4D0V7.
PhosphoSitePlusiA4D0V7.

Polymorphism and mutation databases

BioMutaiCPED1.

Proteomic databases

MaxQBiA4D0V7.
PaxDbiA4D0V7.
PRIDEiA4D0V7.

Protocols and materials databases

DNASUi79974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310396; ENSP00000309772; ENSG00000106034. [A4D0V7-1]
ENST00000450913; ENSP00000406122; ENSG00000106034. [A4D0V7-2]
GeneIDi79974.
KEGGihsa:79974.
UCSCiuc003vjq.5. human. [A4D0V7-1]

Organism-specific databases

CTDi79974.
DisGeNETi79974.
GeneCardsiCPED1.
H-InvDBHIX0201130.
HGNCiHGNC:26159. CPED1.
HPAiHPA012058.
neXtProtiNX_A4D0V7.
OpenTargetsiENSG00000106034.
PharmGKBiPA162380636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEF4. Eukaryota.
ENOG4110TQ2. LUCA.
GeneTreeiENSGT00390000015216.
HOVERGENiHBG095603.
InParanoidiA4D0V7.
OMAiVQDCGLL.
OrthoDBiEOG091G08E5.
PhylomeDBiA4D0V7.
TreeFamiTF332741.

Miscellaneous databases

GeneWikiiFLJ21986.
GenomeRNAii79974.
PROiA4D0V7.

Gene expression databases

BgeeiENSG00000106034.
CleanExiHS_C7orf58.
ExpressionAtlasiA4D0V7. baseline and differential.
GenevisibleiA4D0V7. HS.

Family and domain databases

InterProiIPR025883. Cadherin-like_b_sandwich.
[Graphical view]
PfamiPF12733. Cadherin-like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPED1_HUMAN
AccessioniPrimary (citable) accession number: A4D0V7
Secondary accession number(s): A8K1R3
, Q6UXT1, Q86T76, Q86T84, Q8N2T5, Q96NC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.