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A4D0V7

- CPED1_HUMAN

UniProt

A4D0V7 - CPED1_HUMAN

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Protein

Cadherin-like and PC-esterase domain-containing protein 1

Gene

CPED1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-like and PC-esterase domain-containing protein 1
Gene namesi
Name:CPED1
Synonyms:C7orf58
ORF Names:UNQ9432/PRO34713
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:26159. CPED1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 1026992Cadherin-like and PC-esterase domain-containing protein 1PRO_0000317732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi985 – 9851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA4D0V7.
PaxDbiA4D0V7.
PRIDEiA4D0V7.

PTM databases

PhosphoSiteiA4D0V7.

Expressioni

Gene expression databases

BgeeiA4D0V7.
CleanExiHS_C7orf58.
ExpressionAtlasiA4D0V7. baseline and differential.
GenevestigatoriA4D0V7.

Organism-specific databases

HPAiHPA012058.

Interactioni

Protein-protein interaction databases

BioGridi123041. 1 interaction.
IntActiA4D0V7. 1 interaction.
MINTiMINT-4722683.

Structurei

3D structure databases

ProteinModelPortaliA4D0V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PC-esterase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG29130.
GeneTreeiENSGT00390000015216.
HOVERGENiHBG095603.
InParanoidiA4D0V7.
OMAiVQDCGLL.
PhylomeDBiA4D0V7.
TreeFamiTF332741.

Family and domain databases

InterProiIPR025883. Cadherin-like_b_sandwich.
IPR026057. PC-Esterase.
[Graphical view]
PfamiPF12733. Cadherin-like. 1 hit.
PF13839. PC-Esterase. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A4D0V7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP
60 70 80 90 100
HTSTETQASR CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI
110 120 130 140 150
LYRPPFYSKT ELQLHQHILT QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW
160 170 180 190 200
DLLICLSSKK AEGTPCISKE VMCQLGLHQK ANRLPEIQQP LCRKEGLCQI
210 220 230 240 250
VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW KPGDWSREQL
260 270 280 290 300
NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
310 320 330 340 350
KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK
360 370 380 390 400
TFHRCRFCFQ LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE
410 420 430 440 450
FLLNDTFNFL FPNESSLSIF SEIFQRLYRS DVFKGENYQK ELNQCLSLEE
460 470 480 490 500
INSIMTFIKE LGSLGQFQLL FPSTTPGIQS LMHEFYDVAN PVGNPGSVLT
510 520 530 540 550
QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV PFDAIENKKA
560 570 580 590 600
AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
610 620 630 640 650
PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES
660 670 680 690 700
PAHGETLITY KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ
710 720 730 740 750
PISSDYIEAI LQSELKRCPS GDMKGQWIVP CLSCSDNRTC DWREITWQPH
760 770 780 790 800
NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR GIMYYLIERL NETLQEWQKV
810 820 830 840 850
HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH LLQRSRPLEN
860 870 880 890 900
TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
910 920 930 940 950
GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC
960 970 980 990 1000
GCHFHEVVKS KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP
1010 1020
YHVRGPINQV CSEILLSRMC ANKRTM
Length:1,026
Mass (Da):117,491
Last modified:April 3, 2007 - v1
Checksum:i7C3E91FAF7494440
GO
Isoform 2 (identifier: A4D0V7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-783: ILFIGDSTNRGIM → LGVDVQRVPRSRN
     784-1026: Missing.

Note: No experimental confirmation available.

Show »
Length:783
Mass (Da):89,175
Checksum:i3BE8B0AA01D1FB0B
GO

Sequence cautioni

The sequence AAH30538.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731C → R in CAD89961. (PubMed:17974005)Curated
Sequence conflicti186 – 1861E → G in BAF82667. (PubMed:14702039)Curated
Sequence conflicti262 – 2621I → T in CAD89961. (PubMed:17974005)Curated
Sequence conflicti641 – 6411K → R in CAD89961. (PubMed:17974005)Curated
Sequence conflicti795 – 7951Q → R in CAD89961. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti326 – 3261I → T.
Corresponds to variant rs17143165 [ dbSNP | Ensembl ].
VAR_038664
Natural varianti551 – 5511A → G.3 Publications
Corresponds to variant rs41281692 [ dbSNP | Ensembl ].
VAR_038665
Natural varianti708 – 7081E → G.2 Publications
Corresponds to variant rs35793694 [ dbSNP | Ensembl ].
VAR_038666
Natural varianti949 – 9491K → T.
Corresponds to variant rs798911 [ dbSNP | Ensembl ].
VAR_038667

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei771 – 78313ILFIG…NRGIM → LGVDVQRVPRSRN in isoform 2. 2 PublicationsVSP_031140Add
BLAST
Alternative sequencei784 – 1026243Missing in isoform 2. 2 PublicationsVSP_031141Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358220 mRNA. Translation: AAQ88587.1.
AK055624 mRNA. Translation: BAB70974.1.
AK289978 mRNA. Translation: BAF82667.1.
AL832619 mRNA. Translation: CAD89961.1.
AL832638 mRNA. Translation: CAD89953.1.
CH236947 Genomic DNA. Translation: EAL24348.1.
BC030538 mRNA. Translation: AAH30538.1. Different initiation.
CCDSiCCDS34739.1. [A4D0V7-1]
CCDS47690.1. [A4D0V7-2]
RefSeqiNP_001099003.1. NM_001105533.1. [A4D0V7-2]
NP_079189.4. NM_024913.4. [A4D0V7-1]
UniGeneiHs.189652.

Genome annotation databases

EnsembliENST00000310396; ENSP00000309772; ENSG00000106034. [A4D0V7-1]
ENST00000450913; ENSP00000406122; ENSG00000106034. [A4D0V7-2]
GeneIDi79974.
KEGGihsa:79974.
UCSCiuc003vjq.4. human. [A4D0V7-1]
uc003vjs.4. human. [A4D0V7-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358220 mRNA. Translation: AAQ88587.1 .
AK055624 mRNA. Translation: BAB70974.1 .
AK289978 mRNA. Translation: BAF82667.1 .
AL832619 mRNA. Translation: CAD89961.1 .
AL832638 mRNA. Translation: CAD89953.1 .
CH236947 Genomic DNA. Translation: EAL24348.1 .
BC030538 mRNA. Translation: AAH30538.1 . Different initiation.
CCDSi CCDS34739.1. [A4D0V7-1 ]
CCDS47690.1. [A4D0V7-2 ]
RefSeqi NP_001099003.1. NM_001105533.1. [A4D0V7-2 ]
NP_079189.4. NM_024913.4. [A4D0V7-1 ]
UniGenei Hs.189652.

3D structure databases

ProteinModelPortali A4D0V7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123041. 1 interaction.
IntActi A4D0V7. 1 interaction.
MINTi MINT-4722683.

PTM databases

PhosphoSitei A4D0V7.

Proteomic databases

MaxQBi A4D0V7.
PaxDbi A4D0V7.
PRIDEi A4D0V7.

Protocols and materials databases

DNASUi 79974.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310396 ; ENSP00000309772 ; ENSG00000106034 . [A4D0V7-1 ]
ENST00000450913 ; ENSP00000406122 ; ENSG00000106034 . [A4D0V7-2 ]
GeneIDi 79974.
KEGGi hsa:79974.
UCSCi uc003vjq.4. human. [A4D0V7-1 ]
uc003vjs.4. human. [A4D0V7-2 ]

Organism-specific databases

CTDi 79974.
GeneCardsi GC07P120629.
H-InvDB HIX0201130.
HGNCi HGNC:26159. CPED1.
HPAi HPA012058.
neXtProti NX_A4D0V7.
PharmGKBi PA162380636.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG29130.
GeneTreei ENSGT00390000015216.
HOVERGENi HBG095603.
InParanoidi A4D0V7.
OMAi VQDCGLL.
PhylomeDBi A4D0V7.
TreeFami TF332741.

Miscellaneous databases

GeneWikii FLJ21986.
GenomeRNAii 79974.
NextBioi 70002.
PROi A4D0V7.

Gene expression databases

Bgeei A4D0V7.
CleanExi HS_C7orf58.
ExpressionAtlasi A4D0V7. baseline and differential.
Genevestigatori A4D0V7.

Family and domain databases

InterProi IPR025883. Cadherin-like_b_sandwich.
IPR026057. PC-Esterase.
[Graphical view ]
Pfami PF12733. Cadherin-like. 1 hit.
PF13839. PC-Esterase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-551.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-551 AND GLY-708.
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-708.
    Tissue: Spinal cord.
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-802 (ISOFORM 2), VARIANT GLY-551.
    Tissue: Skin.

Entry informationi

Entry nameiCPED1_HUMAN
AccessioniPrimary (citable) accession number: A4D0V7
Secondary accession number(s): A8K1R3
, Q6UXT1, Q86T76, Q86T84, Q8N2T5, Q96NC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3