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A4D0V7

- CPED1_HUMAN

UniProt

A4D0V7 - CPED1_HUMAN

Protein

Cadherin-like and PC-esterase domain-containing protein 1

Gene

CPED1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-like and PC-esterase domain-containing protein 1
    Gene namesi
    Name:CPED1
    Synonyms:C7orf58
    ORF Names:UNQ9432/PRO34713
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:26159. CPED1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380636.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 1026992Cadherin-like and PC-esterase domain-containing protein 1PRO_0000317732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi985 – 9851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiA4D0V7.
    PaxDbiA4D0V7.
    PRIDEiA4D0V7.

    PTM databases

    PhosphoSiteiA4D0V7.

    Expressioni

    Gene expression databases

    ArrayExpressiA4D0V7.
    BgeeiA4D0V7.
    CleanExiHS_C7orf58.
    GenevestigatoriA4D0V7.

    Organism-specific databases

    HPAiHPA012058.

    Interactioni

    Protein-protein interaction databases

    BioGridi123041. 1 interaction.
    IntActiA4D0V7. 1 interaction.
    MINTiMINT-4722683.

    Structurei

    3D structure databases

    ProteinModelPortaliA4D0V7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PC-esterase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG29130.
    HOVERGENiHBG095603.
    InParanoidiA4D0V7.
    OMAiVQDCGLL.
    PhylomeDBiA4D0V7.
    TreeFamiTF332741.

    Family and domain databases

    InterProiIPR025883. Cadherin-like_b_sandwich.
    IPR026057. PC-Esterase.
    [Graphical view]
    PfamiPF12733. Cadherin-like. 1 hit.
    PF13839. PC-Esterase. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A4D0V7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP     50
    HTSTETQASR CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI 100
    LYRPPFYSKT ELQLHQHILT QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW 150
    DLLICLSSKK AEGTPCISKE VMCQLGLHQK ANRLPEIQQP LCRKEGLCQI 200
    VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW KPGDWSREQL 250
    NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK 300
    KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK 350
    TFHRCRFCFQ LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE 400
    FLLNDTFNFL FPNESSLSIF SEIFQRLYRS DVFKGENYQK ELNQCLSLEE 450
    INSIMTFIKE LGSLGQFQLL FPSTTPGIQS LMHEFYDVAN PVGNPGSVLT 500
    QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV PFDAIENKKA 550
    AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV 600
    PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES 650
    PAHGETLITY KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ 700
    PISSDYIEAI LQSELKRCPS GDMKGQWIVP CLSCSDNRTC DWREITWQPH 750
    NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR GIMYYLIERL NETLQEWQKV 800
    HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH LLQRSRPLEN 850
    TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD 900
    GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC 950
    GCHFHEVVKS KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP 1000
    YHVRGPINQV CSEILLSRMC ANKRTM 1026
    Length:1,026
    Mass (Da):117,491
    Last modified:April 3, 2007 - v1
    Checksum:i7C3E91FAF7494440
    GO
    Isoform 2 (identifier: A4D0V7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         771-783: ILFIGDSTNRGIM → LGVDVQRVPRSRN
         784-1026: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:783
    Mass (Da):89,175
    Checksum:i3BE8B0AA01D1FB0B
    GO

    Sequence cautioni

    The sequence AAH30538.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731C → R in CAD89961. (PubMed:17974005)Curated
    Sequence conflicti186 – 1861E → G in BAF82667. (PubMed:14702039)Curated
    Sequence conflicti262 – 2621I → T in CAD89961. (PubMed:17974005)Curated
    Sequence conflicti641 – 6411K → R in CAD89961. (PubMed:17974005)Curated
    Sequence conflicti795 – 7951Q → R in CAD89961. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti326 – 3261I → T.
    Corresponds to variant rs17143165 [ dbSNP | Ensembl ].
    VAR_038664
    Natural varianti551 – 5511A → G.3 Publications
    Corresponds to variant rs41281692 [ dbSNP | Ensembl ].
    VAR_038665
    Natural varianti708 – 7081E → G.2 Publications
    Corresponds to variant rs35793694 [ dbSNP | Ensembl ].
    VAR_038666
    Natural varianti949 – 9491K → T.
    Corresponds to variant rs798911 [ dbSNP | Ensembl ].
    VAR_038667

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei771 – 78313ILFIG…NRGIM → LGVDVQRVPRSRN in isoform 2. 2 PublicationsVSP_031140Add
    BLAST
    Alternative sequencei784 – 1026243Missing in isoform 2. 2 PublicationsVSP_031141Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358220 mRNA. Translation: AAQ88587.1.
    AK055624 mRNA. Translation: BAB70974.1.
    AK289978 mRNA. Translation: BAF82667.1.
    AL832619 mRNA. Translation: CAD89961.1.
    AL832638 mRNA. Translation: CAD89953.1.
    CH236947 Genomic DNA. Translation: EAL24348.1.
    BC030538 mRNA. Translation: AAH30538.1. Different initiation.
    CCDSiCCDS34739.1. [A4D0V7-1]
    CCDS47690.1. [A4D0V7-2]
    RefSeqiNP_001099003.1. NM_001105533.1. [A4D0V7-2]
    NP_079189.4. NM_024913.4. [A4D0V7-1]
    UniGeneiHs.189652.

    Genome annotation databases

    EnsembliENST00000310396; ENSP00000309772; ENSG00000106034. [A4D0V7-1]
    ENST00000450913; ENSP00000406122; ENSG00000106034. [A4D0V7-2]
    GeneIDi79974.
    KEGGihsa:79974.
    UCSCiuc003vjq.4. human. [A4D0V7-1]
    uc003vjs.4. human. [A4D0V7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358220 mRNA. Translation: AAQ88587.1 .
    AK055624 mRNA. Translation: BAB70974.1 .
    AK289978 mRNA. Translation: BAF82667.1 .
    AL832619 mRNA. Translation: CAD89961.1 .
    AL832638 mRNA. Translation: CAD89953.1 .
    CH236947 Genomic DNA. Translation: EAL24348.1 .
    BC030538 mRNA. Translation: AAH30538.1 . Different initiation.
    CCDSi CCDS34739.1. [A4D0V7-1 ]
    CCDS47690.1. [A4D0V7-2 ]
    RefSeqi NP_001099003.1. NM_001105533.1. [A4D0V7-2 ]
    NP_079189.4. NM_024913.4. [A4D0V7-1 ]
    UniGenei Hs.189652.

    3D structure databases

    ProteinModelPortali A4D0V7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123041. 1 interaction.
    IntActi A4D0V7. 1 interaction.
    MINTi MINT-4722683.

    PTM databases

    PhosphoSitei A4D0V7.

    Proteomic databases

    MaxQBi A4D0V7.
    PaxDbi A4D0V7.
    PRIDEi A4D0V7.

    Protocols and materials databases

    DNASUi 79974.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310396 ; ENSP00000309772 ; ENSG00000106034 . [A4D0V7-1 ]
    ENST00000450913 ; ENSP00000406122 ; ENSG00000106034 . [A4D0V7-2 ]
    GeneIDi 79974.
    KEGGi hsa:79974.
    UCSCi uc003vjq.4. human. [A4D0V7-1 ]
    uc003vjs.4. human. [A4D0V7-2 ]

    Organism-specific databases

    CTDi 79974.
    GeneCardsi GC07P120629.
    H-InvDB HIX0201130.
    HGNCi HGNC:26159. CPED1.
    HPAi HPA012058.
    neXtProti NX_A4D0V7.
    PharmGKBi PA162380636.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG29130.
    HOVERGENi HBG095603.
    InParanoidi A4D0V7.
    OMAi VQDCGLL.
    PhylomeDBi A4D0V7.
    TreeFami TF332741.

    Miscellaneous databases

    GeneWikii FLJ21986.
    GenomeRNAii 79974.
    NextBioi 70002.
    PROi A4D0V7.

    Gene expression databases

    ArrayExpressi A4D0V7.
    Bgeei A4D0V7.
    CleanExi HS_C7orf58.
    Genevestigatori A4D0V7.

    Family and domain databases

    InterProi IPR025883. Cadherin-like_b_sandwich.
    IPR026057. PC-Esterase.
    [Graphical view ]
    Pfami PF12733. Cadherin-like. 1 hit.
    PF13839. PC-Esterase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-551.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-551 AND GLY-708.
      Tissue: Hippocampus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-708.
      Tissue: Spinal cord.
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-802 (ISOFORM 2), VARIANT GLY-551.
      Tissue: Skin.

    Entry informationi

    Entry nameiCPED1_HUMAN
    AccessioniPrimary (citable) accession number: A4D0V7
    Secondary accession number(s): A8K1R3
    , Q6UXT1, Q86T76, Q86T84, Q8N2T5, Q96NC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3