Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4D0V7 (CPED1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-like and PC-esterase domain-containing protein 1
Gene names
Name:CPED1
Synonyms:C7orf58
ORF Names:UNQ9432/PRO34713
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1026 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PC-esterase family.

Sequence caution

The sequence AAH30538.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from direct assay. Source: LIFEdb

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A4D0V7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A4D0V7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     771-783: ILFIGDSTNRGIM → LGVDVQRVPRSRN
     784-1026: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 1026992Cadherin-like and PC-esterase domain-containing protein 1
PRO_0000317732

Amino acid modifications

Glycosylation2511N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential
Glycosylation7371N-linked (GlcNAc...) Potential
Glycosylation7911N-linked (GlcNAc...) Potential
Glycosylation9851N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence771 – 78313ILFIG…NRGIM → LGVDVQRVPRSRN in isoform 2.
VSP_031140
Alternative sequence784 – 1026243Missing in isoform 2.
VSP_031141
Natural variant3261I → T.
Corresponds to variant rs17143165 [ dbSNP | Ensembl ].
VAR_038664
Natural variant5511A → G. Ref.1 Ref.2 Ref.5
Corresponds to variant rs41281692 [ dbSNP | Ensembl ].
VAR_038665
Natural variant7081E → G. Ref.2 Ref.3
Corresponds to variant rs35793694 [ dbSNP | Ensembl ].
VAR_038666
Natural variant9491K → T.
Corresponds to variant rs798911 [ dbSNP | Ensembl ].
VAR_038667

Experimental info

Sequence conflict1731C → R in CAD89961. Ref.3
Sequence conflict1861E → G in BAF82667. Ref.2
Sequence conflict2621I → T in CAD89961. Ref.3
Sequence conflict6411K → R in CAD89961. Ref.3
Sequence conflict7951Q → R in CAD89961. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 7C3E91FAF7494440

FASTA1,026117,491
        10         20         30         40         50         60 
MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP HTSTETQASR 

        70         80         90        100        110        120 
CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI LYRPPFYSKT ELQLHQHILT 

       130        140        150        160        170        180 
QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW DLLICLSSKK AEGTPCISKE VMCQLGLHQK 

       190        200        210        220        230        240 
ANRLPEIQQP LCRKEGLCQI VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW 

       250        260        270        280        290        300 
KPGDWSREQL NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK 

       310        320        330        340        350        360 
KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK TFHRCRFCFQ 

       370        380        390        400        410        420 
LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE FLLNDTFNFL FPNESSLSIF 

       430        440        450        460        470        480 
SEIFQRLYRS DVFKGENYQK ELNQCLSLEE INSIMTFIKE LGSLGQFQLL FPSTTPGIQS 

       490        500        510        520        530        540 
LMHEFYDVAN PVGNPGSVLT QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV 

       550        560        570        580        590        600 
PFDAIENKKA AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV 

       610        620        630        640        650        660 
PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES PAHGETLITY 

       670        680        690        700        710        720 
KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ PISSDYIEAI LQSELKRCPS 

       730        740        750        760        770        780 
GDMKGQWIVP CLSCSDNRTC DWREITWQPH NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR 

       790        800        810        820        830        840 
GIMYYLIERL NETLQEWQKV HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH 

       850        860        870        880        890        900 
LLQRSRPLEN TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD 

       910        920        930        940        950        960 
GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC GCHFHEVVKS 

       970        980        990       1000       1010       1020 
KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP YHVRGPINQV CSEILLSRMC 


ANKRTM 

« Hide

Isoform 2 [UniParc].

Checksum: 3BE8B0AA01D1FB0B
Show »

FASTA78389,175

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-551.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-551 AND GLY-708.
Tissue: Hippocampus.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-708.
Tissue: Spinal cord.
[4]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-802 (ISOFORM 2), VARIANT GLY-551.
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358220 mRNA. Translation: AAQ88587.1.
AK055624 mRNA. Translation: BAB70974.1.
AK289978 mRNA. Translation: BAF82667.1.
AL832619 mRNA. Translation: CAD89961.1.
AL832638 mRNA. Translation: CAD89953.1.
CH236947 Genomic DNA. Translation: EAL24348.1.
BC030538 mRNA. Translation: AAH30538.1. Different initiation.
RefSeqNP_001099003.1. NM_001105533.1.
NP_079189.4. NM_024913.4.
UniGeneHs.189652.

3D structure databases

ProteinModelPortalA4D0V7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123041. 1 interaction.
IntActA4D0V7. 1 interaction.
MINTMINT-4722683.

PTM databases

PhosphoSiteA4D0V7.

Proteomic databases

PaxDbA4D0V7.
PRIDEA4D0V7.

Protocols and materials databases

DNASU79974.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310396; ENSP00000309772; ENSG00000106034. [A4D0V7-1]
ENST00000450913; ENSP00000406122; ENSG00000106034. [A4D0V7-2]
GeneID79974.
KEGGhsa:79974.
UCSCuc003vjq.4. human. [A4D0V7-1]
uc003vjs.4. human. [A4D0V7-2]

Organism-specific databases

CTD79974.
GeneCardsGC07P120629.
H-InvDBHIX0201130.
HGNCHGNC:26159. CPED1.
HPAHPA012058.
neXtProtNX_A4D0V7.
PharmGKBPA162380636.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG29130.
HOVERGENHBG095603.
InParanoidA4D0V7.
OMAVQDCGLL.
PhylomeDBA4D0V7.
TreeFamTF332741.

Gene expression databases

ArrayExpressA4D0V7.
BgeeA4D0V7.
CleanExHS_C7orf58.
GenevestigatorA4D0V7.

Family and domain databases

InterProIPR025883. Cadherin-like_b_sandwich.
IPR026057. PC-Esterase.
[Graphical view]
PfamPF12733. Cadherin-like. 1 hit.
PF13839. PC-Esterase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFLJ21986.
GenomeRNAi79974.
NextBio70002.
PROA4D0V7.

Entry information

Entry nameCPED1_HUMAN
AccessionPrimary (citable) accession number: A4D0V7
Secondary accession number(s): A8K1R3 expand/collapse secondary AC list , Q6UXT1, Q86T76, Q86T84, Q8N2T5, Q96NC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM