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Protein
Submitted name:

Capping protein (Actin filament) muscle Z-line, alpha 2

Gene

CAPZA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin cappingSAAS annotation, Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Capping protein (Actin filament) muscle Z-line, alpha 2Imported
Submitted name:
Capping protein (Actin filament) muscle Z-line, alpha 2, isoform CRA_bImported
Submitted name:
cDNA, FLJ95684, Homo sapiens capping protein (actin filament) muscle Z-line, alpha2 (CAPZA2), mRNAImported
Gene namesi
Name:CAPZA2Imported
ORF Names:hCG_37884Imported, tcag7.31Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000198898.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26071

PTM / Processingi

Proteomic databases

PRIDEiA4D0V4

Expressioni

Gene expression databases

BgeeiENSG00000198898
ExpressionAtlasiA4D0V4 baseline and differential

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiA4D0V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili225 – 245Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the F-actin-capping protein alpha subunit family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0836 Eukaryota
ENOG410ZAWX LUCA
HOVERGENiHBG050810
KOiK10364
OMAiWDKVLGY
OrthoDBiEOG091G0KST

Family and domain databases

InterProiView protein in InterPro
IPR002189 CapZ_alpha
IPR037282 CapZ_alpha/beta
IPR017865 F-actin_cap_asu_CS
PANTHERiPTHR10653 PTHR10653, 1 hit
PfamiView protein in Pfam
PF01267 F-actin_cap_A, 1 hit
PRINTSiPR00191 FACTINCAPA
SUPFAMiSSF90096 SSF90096, 1 hit
PROSITEiView protein in PROSITE
PS00748 F_ACTIN_CAPPING_A_1, 1 hit
PS00749 F_ACTIN_CAPPING_A_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4D0V4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA
60 70 80 90 100
AHAFAQYNLD QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH
110 120 130 140 150
LRKEATDPRP CEVENAVESW RTSVETALRA YVKEHYPNGV CTVYGKKIDG
160 170 180 190 200
QQTIIACIES HQFQAKNFWN GRWRSEWKFT ITPSTTQVVG ILKIQVHYYE
210 220 230 240 250
DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ TAISENYQTM
260 270 280
SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA
Length:286
Mass (Da):32,949
Last modified:April 3, 2007 - v1
Checksum:iB5E1B617A38E758B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314808 mRNA Translation: BAG37333.1
CH236947 Genomic DNA Translation: EAL24358.1
CH471070 Genomic DNA Translation: EAW83513.1
CH471070 Genomic DNA Translation: EAW83515.1
RefSeqiNP_006127.1, NM_006136.2
UniGeneiHs.446123

Genome annotation databases

GeneIDi830
KEGGihsa:830

Similar proteinsi

Entry informationi

Entry nameiA4D0V4_HUMAN
AccessioniPrimary (citable) accession number: A4D0V4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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