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A4D0T7 (YG055_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative transmembrane protein LOC401397
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Caution

Product of a dubious CDS prediction.

Sequence caution

The sequence BX537645 differs from that shown. Reason: Frameshift at position 124.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A4D0T7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A4D0T7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Putative transmembrane protein LOC401397
PRO_0000349370

Regions

Transmembrane136 – 15621Helical; Potential
Transmembrane158 – 17821Helical; Potential

Natural variations

Alternative sequence1 – 128128Missing in isoform 2.
VSP_035379

Experimental info

Sequence conflict791H → D in BX537645. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: ECBAC1CB64534A68

FASTA18720,425
        10         20         30         40         50         60 
MDSETPKQKA RDAKFMLVKR LWQDKDGHLC RIVLHDHGWN PSETPVGPQM HGARSLSMEE 

        70         80         90        100        110        120 
SAAAGIVGNV VWRLRPPRHS CNGCFLEGRV TWNLLISASG APGRENFKSD RILYIPFLGT 

       130        140        150        160        170        180 
FSPQDSNIMT SVSTQLSLVL MSLLLVLPVV EAVEAGDAIA LLLGVVLSIT GICACLGVYA 


RKRNGQM 

« Hide

Isoform 2 [UniParc].

Checksum: 73A30C8FC25ED645
Show »

FASTA596,102

References

[1]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skin.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-187 (ISOFORM 1).
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH236947 Genomic DNA. Translation: EAL24371.1.
BC107860 mRNA. No translation available.
BX537645 mRNA. No translation available.
UniGeneHs.117929.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA4D0T7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

neXtProtNX_A4D0T7.

Phylogenomic databases

eggNOGNOG269178.
InParanoidA4D0T7.
OMAMISVSTQ.

Gene expression databases

ArrayExpressA4D0T7.
BgeeA4D0T7.
GenevestigatorA4D0T7.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameYG055_HUMAN
AccessionPrimary (citable) accession number: A4D0T7
Secondary accession number(s): Q32Q38
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM