A4D0T7 (YG055_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Putative transmembrane protein LOC401397
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Caution	Product of a dubious CDS prediction.
Sequence caution	The sequence BX537645 differs from that shown. Reason: Frameshift at position 124.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A4D0T7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A4D0T7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Putative transmembrane protein LOC401397		PRO_0000349370
Regions
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 128	128	Missing in isoform 2.		VSP_035379
Experimental info
	Sequence conflict	79	1	H → D in BX537645. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: ECBAC1CB64534A68	FASTA	187	20,425
	10 20 30 40 50 60 MDSETPKQKA RDAKFMLVKR LWQDKDGHLC RIVLHDHGWN PSETPVGPQM HGARSLSMEE 70 80 90 100 110 120 SAAAGIVGNV VWRLRPPRHS CNGCFLEGRV TWNLLISASG APGRENFKSD RILYIPFLGT 130 140 150 160 170 180 FSPQDSNIMT SVSTQLSLVL MSLLLVLPVV EAVEAGDAIA LLLGVVLSIT GICACLGVYA RKRNGQM
	Isoform 2 [UniParc]. Checksum: 73A30C8FC25ED645	FASTA	59	6,102
	10 20 30 40 50 MTSVSTQLSL VLMSLLLVLP VVEAVEAGDA IALLLGVVLS ITGICACLGV YARKRNGQM

References

[1]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-187 (ISOFORM 1). Tissue: Colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH236947 Genomic DNA. Translation: EAL24371.1. BC107860 mRNA. No translation available. BX537645 mRNA. No translation available.
IPI	IPI00844352. IPI00903087.
UniGene	Hs.117929.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A4D0T7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC07M112756.
neXtProt	NX_A4D0T7.
Phylogenomic databases
eggNOG	NOG269178.
InParanoid	A4D0T7.
OMA	MISVSTQ.
OrthoDB	EOG405S2V.
Gene expression databases
ArrayExpress	A4D0T7.
Bgee	A4D0T7.
Genevestigator	A4D0T7.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

YG055_HUMAN

Accession

Primary (citable) accession number: A4D0T7
Secondary accession number(s): Q32Q38

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.