A4D0S4 (LAMB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Laminin subunit beta-4

Alternative name(s):
Laminin beta-1-related protein

Gene names

Name:

LAMB4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1761 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Subunit structure	Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane.
Domain	The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. Domains VI and IV are globular.
Sequence similarities	Contains 13 laminin EGF-like domains. Contains 1 laminin IV type B domain. Contains 1 laminin N-terminal domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Basement membrane Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Laminin EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	basement membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A4D0S4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A4D0S4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     709-772: LGLIPQINSL...HDGAVACKCH → AAVQWHNLGS...PGWSRTPDLR
     773-1761: Missing.

Isoform 3 (identifier: A4D0S4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1716-1723: DLERKIQD → GCFQNSAR
     1724-1761: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 1761	1742	Laminin subunit beta-4		PRO_0000312857
Regions
	Domain	24 – 264	241	Laminin N-terminal
	Domain	265 – 331	67	Laminin EGF-like 1
	Domain	332 – 394	63	Laminin EGF-like 2
	Domain	395 – 454	60	Laminin EGF-like 3
	Domain	455 – 505	51	Laminin EGF-like 4
	Domain	506 – 552	47	Laminin EGF-like 5; truncated
	Domain	545 – 763	219	Laminin IV type B
	Domain	769 – 816	48	Laminin EGF-like 6
	Domain	817 – 862	46	Laminin EGF-like 7
	Domain	863 – 910	48	Laminin EGF-like 8
	Domain	911 – 969	59	Laminin EGF-like 9
	Domain	970 – 1021	52	Laminin EGF-like 10
	Domain	1022 – 1079	58	Laminin EGF-like 11
	Domain	1080 – 1127	48	Laminin EGF-like 12
	Domain	1128 – 1174	47	Laminin EGF-like 13
	Region	1175 – 1375	201	Domain II
	Region	1376 – 1408	33	Domain alpha
	Region	1409 – 1761	353	Domain I
	Coiled coil	1243 – 1301	59	Potential
	Coiled coil	1416 – 1480	65	Potential
	Coiled coil	1525 – 1759	235	Potential
Amino acid modifications
	Glycosylation	169	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...) Potential
	Glycosylation	246	1	N-linked (GlcNAc...) Potential
	Glycosylation	1016	1	N-linked (GlcNAc...) Potential
	Glycosylation	1055	1	N-linked (GlcNAc...) Potential
	Glycosylation	1223	1	N-linked (GlcNAc...) Potential
	Glycosylation	1301	1	N-linked (GlcNAc...) Potential
	Glycosylation	1326	1	N-linked (GlcNAc...) Potential
	Glycosylation	1333	1	N-linked (GlcNAc...) Potential
	Glycosylation	1354	1	N-linked (GlcNAc...) Potential
	Glycosylation	1469	1	N-linked (GlcNAc...) Potential
	Glycosylation	1517	1	N-linked (GlcNAc...) Potential
	Glycosylation	1587	1	N-linked (GlcNAc...) Potential
	Glycosylation	1596	1	N-linked (GlcNAc...) Potential
	Glycosylation	1609	1	N-linked (GlcNAc...) Potential
	Glycosylation	1725	1	N-linked (GlcNAc...) Potential
	Disulfide bond	265 ↔ ?274		By similarity
	Disulfide bond	267 ↔ 295		By similarity
	Disulfide bond	297 ↔ 306		By similarity
	Disulfide bond	309 ↔ 329		By similarity
	Disulfide bond	332 ↔ 341		By similarity
	Disulfide bond	334 ↔ 359		By similarity
	Disulfide bond	362 ↔ 371		By similarity
	Disulfide bond	374 ↔ 392		By similarity
	Disulfide bond	395 ↔ 408		By similarity
	Disulfide bond	397 ↔ 423		By similarity
	Disulfide bond	425 ↔ 434		By similarity
	Disulfide bond	437 ↔ 452		By similarity
	Disulfide bond	455 ↔ 468		By similarity
	Disulfide bond	457 ↔ 475		By similarity
	Disulfide bond	477 ↔ 486		By similarity
	Disulfide bond	489 ↔ 503		By similarity
	Disulfide bond	506 ↔ 518		By similarity
	Disulfide bond	508 ↔ 525		By similarity
	Disulfide bond	527 ↔ 536		By similarity
	Disulfide bond	769 ↔ 781		By similarity
	Disulfide bond	771 ↔ 788		By similarity
	Disulfide bond	790 ↔ 799		By similarity
	Disulfide bond	802 ↔ 814		By similarity
	Disulfide bond	817 ↔ 829		By similarity
	Disulfide bond	819 ↔ 836		By similarity
	Disulfide bond	838 ↔ 847		By similarity
	Disulfide bond	850 ↔ 860		By similarity
	Disulfide bond	863 ↔ 872		By similarity
	Disulfide bond	865 ↔ 879		By similarity
	Disulfide bond	882 ↔ 891		By similarity
	Disulfide bond	894 ↔ 908		By similarity
	Disulfide bond	913 ↔ 938		By similarity
	Disulfide bond	940 ↔ 949		By similarity
	Disulfide bond	952 ↔ 967		By similarity
	Disulfide bond	970 ↔ 984		By similarity
	Disulfide bond	972 ↔ 991		By similarity
	Disulfide bond	994 ↔ 1003		By similarity
	Disulfide bond	1006 ↔ 1019		By similarity
	Disulfide bond	1022 ↔ 1043		By similarity
	Disulfide bond	1024 ↔ 1050		By similarity
	Disulfide bond	1052 ↔ 1061		By similarity
	Disulfide bond	1064 ↔ 1077		By similarity
	Disulfide bond	1080 ↔ 1092		By similarity
	Disulfide bond	1082 ↔ 1099		By similarity
	Disulfide bond	1101 ↔ 1110		By similarity
	Disulfide bond	1113 ↔ 1125		By similarity
	Disulfide bond	1128 ↔ 1140		By similarity
	Disulfide bond	1130 ↔ 1147		By similarity
	Disulfide bond	1149 ↔ 1158		By similarity
	Disulfide bond	1161 ↔ 1172		By similarity
	Disulfide bond	1175		Interchain Probable
	Disulfide bond	1178		Interchain Probable
	Disulfide bond	1759		Interchain Probable
Natural variations
	Alternative sequence	709 – 772	64	LGLIP…ACKCH → AAVQWHNLGSLQPPPPECKQ FSCFSFPSSWDYRHPPPHLA SFCIFSRDGVSPHWPGWSRT PDLR in isoform 2.		VSP_029913
	Alternative sequence	773 – 1761	989	Missing in isoform 2.		VSP_029914
	Alternative sequence	1716 – 1723	8	DLERKIQD → GCFQNSAR in isoform 3.		VSP_029915
	Alternative sequence	1724 – 1761	38	Missing in isoform 3.		VSP_029916
	Natural variant	44	1	M → T. Corresponds to variant rs35644375 [ dbSNP | Ensembl ].		VAR_037588
	Natural variant	234	1	H → Y. Corresponds to variant rs2074749 [ dbSNP | Ensembl ].		VAR_037589
	Natural variant	591	1	V → F. Corresponds to variant rs9690688 [ dbSNP | Ensembl ].		VAR_037590
	Natural variant	866	1	N → S. Corresponds to variant rs2240445 [ dbSNP | Ensembl ].		VAR_037591
	Natural variant	1350	1	T → N. Corresponds to variant rs10260756 [ dbSNP | Ensembl ].		VAR_037592
	Natural variant	1510	1	H → Y. Corresponds to variant rs1627354 [ dbSNP | Ensembl ].		VAR_037593
	Natural variant	1612	1	R → S. Corresponds to variant rs2528693 [ dbSNP | Ensembl ].		VAR_037594
Experimental info
	Sequence conflict	70	1	F → S in AAC95123. Ref.1
	Sequence conflict	93	1	I → T in AAC95123. Ref.1
	Sequence conflict	1542	1	L → S in AAC95123. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 57A740F079CE1FB2	FASTA	1,761	193,540
	10 20 30 40 50 60 MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLMASSTCG LSRAQKYCIL 70 80 90 100 110 120 SYLEGEQKCF ICDSRFPYDP YDQPNSHTIE NVIVSFEPDR EKKWWQSENG LDHVSIRLDL 130 140 150 160 170 180 EALFRFSHLI LTFKTFRPAA MLVERSTDYG HNWKVFKYFA KDCATSFPNI TSGQAQGVGD 190 200 210 220 230 240 IVCDSKYSDI EPSTGGEVVL KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLHTLGDAL 250 260 270 280 290 300 LGRRQNDSLD KYYYALYEMI VRGSCFCNGH ASECRPMQKM RGDVFSPPGM VHGQCVCQHN 310 320 330 340 350 360 TDGPNCERCK DFFQDAPWRP AADLQDNACR SCSCNSHSSR CHFDMTTYLA SGGLSGGVCE 370 380 390 400 410 420 DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD GTISGGICVS HSDPALGSVA 430 440 450 460 470 480 GQCLCKENVE GAKCDQCKPN HYGLSATDPL GCQPCDCNPL GSLPFLTCDV DTGQCLCLSY 490 500 510 520 530 540 VTGAHCEECT VGYWGLGNHL HGCSPCDCDI GGAYSNVCSP KNGQCECRPH VTGRSCSEPA 550 560 570 580 590 600 PGYFFAPLNF YLYEAEEATT LQGLAPLGSE TFGQSPAVHV VLGEPVPGNP VTWTGPGFAR 610 620 630 640 650 660 VLPGAGLRFA VNNIPFPVDF TIAIHYETQS AADWTVQIVV NPPGGSEHCI PKTLQSKPQS 670 680 690 700 710 720 FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLQGESHA HSHVLVDSLG LIPQINSLEN 730 740 750 760 770 780 FCSKQDLDEY QLHNCVEIAS AMGPQVLPGA CERLIISMSA KLHDGAVACK CHPQGSVGSS 790 800 810 820 830 840 CSRLGGQCQC KPLVVGRCCD RCSTGSYDLG HHGCHPCHCH PQGSKDTVCD QVTGQCPCHG 850 860 870 880 890 900 EVSGRRCDRC LAGYFGFPSC HPCPCNRFAE LCDPETGSCF NCGGFTTGRN CERCIDGYYG 910 920 930 940 950 960 NPSSGQPCRP CLCPDDPSSN QYFAHSCYQN LWSSDVICNC LQGYTGTQCG ECSTGFYGNP 970 980 990 1000 1010 1020 RISGAPCQPC ACNNNIDVTD PESCSRVTGE CLRCLHNTQG ANCQLCKPGH YGSALNQTCR 1030 1040 1050 1060 1070 1080 RCSCHASGVS PMECPPGGGA CLCDPVTGAC PCLPNVTGLA CDRCADGYWN LVPGRGCQSC 1090 1100 1110 1120 1130 1140 DCDPRTSQSS HCDQLTGQCP CKLGYGGKRC SECQENYYGD PPGRCIPCDC NRAGTQKPIC 1150 1160 1170 1180 1190 1200 DPDTGMCRCR EGVSGQRCDR CARGHSQEFP TCLQCHLCFD QWDHTISSLS KAVQGLMRLA 1210 1220 1230 1240 1250 1260 ANMEDKRETL PVCEADFKDL RGNVSEIERI LKHPVFPSGK FLKVKDYHDS VRRQIMQLNE 1270 1280 1290 1300 1310 1320 QLKAVYEFQD LKDTIERAKN EADLLLEDLQ EEIDLQSSVL NASIADSSEN IKKYYHISSS 1330 1340 1350 1360 1370 1380 AEKKINETSS TINTSANTRN DLLTILDTLT SKGNLSLERL KQIKIPDIQI LNEKVCGDPG 1390 1400 1410 1420 1430 1440 NVPCVPLPCG GALCTGRKGH RKCRGPGCHG SLTLSTNALQ KAQEAKSIIR NLDKQVRGLK 1450 1460 1470 1480 1490 1500 NQIESISEQA EVSKNNALQL REKLGNIRNQ SDSEEENINL FIKKVKNFLL EENVPPEDIE 1510 1520 1530 1540 1550 1560 KVANGVLDIH LPIPSQNLTD ELVKIQKHMQ LCEDYRTDEN RLNEEADGAQ KLLVKAKAAE 1570 1580 1590 1600 1610 1620 KAANILLNLD KTLNQLQQAQ ITQGRANSTI TQLTANITKI KKNVLQAENQ TREMKSELEL 1630 1640 1650 1660 1670 1680 AKQRSGLEDG LSLLQTKLQR HQDHAVNAKV QAESAQHQAG SLEKEFVELK KQYAILQRKT 1690 1700 1710 1720 1730 1740 STTGLTKETL GKVKQLKDAA EKLAGDTEAK IRRITDLERK IQDLNLSRQA KADQLRILED 1750 1760 QVVAIKNEIV EQEKKYARCY S
	Isoform 2 [UniParc]. Checksum: B74332DD472E0C6B	FASTA	772	85,105
	10 20 30 40 50 60 MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLMASSTCG LSRAQKYCIL 70 80 90 100 110 120 SYLEGEQKCF ICDSRFPYDP YDQPNSHTIE NVIVSFEPDR EKKWWQSENG LDHVSIRLDL 130 140 150 160 170 180 EALFRFSHLI LTFKTFRPAA MLVERSTDYG HNWKVFKYFA KDCATSFPNI TSGQAQGVGD 190 200 210 220 230 240 IVCDSKYSDI EPSTGGEVVL KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLHTLGDAL 250 260 270 280 290 300 LGRRQNDSLD KYYYALYEMI VRGSCFCNGH ASECRPMQKM RGDVFSPPGM VHGQCVCQHN 310 320 330 340 350 360 TDGPNCERCK DFFQDAPWRP AADLQDNACR SCSCNSHSSR CHFDMTTYLA SGGLSGGVCE 370 380 390 400 410 420 DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD GTISGGICVS HSDPALGSVA 430 440 450 460 470 480 GQCLCKENVE GAKCDQCKPN HYGLSATDPL GCQPCDCNPL GSLPFLTCDV DTGQCLCLSY 490 500 510 520 530 540 VTGAHCEECT VGYWGLGNHL HGCSPCDCDI GGAYSNVCSP KNGQCECRPH VTGRSCSEPA 550 560 570 580 590 600 PGYFFAPLNF YLYEAEEATT LQGLAPLGSE TFGQSPAVHV VLGEPVPGNP VTWTGPGFAR 610 620 630 640 650 660 VLPGAGLRFA VNNIPFPVDF TIAIHYETQS AADWTVQIVV NPPGGSEHCI PKTLQSKPQS 670 680 690 700 710 720 FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLQGESHA HSHVLVDSAA VQWHNLGSLQ 730 740 750 760 770 PPPPECKQFS CFSFPSSWDY RHPPPHLASF CIFSRDGVSP HWPGWSRTPD LR
	Isoform 3 [UniParc]. Checksum: EF23F9CBED1266A7	FASTA	1,723	188,959
	10 20 30 40 50 60 MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLMASSTCG LSRAQKYCIL 70 80 90 100 110 120 SYLEGEQKCF ICDSRFPYDP YDQPNSHTIE NVIVSFEPDR EKKWWQSENG LDHVSIRLDL 130 140 150 160 170 180 EALFRFSHLI LTFKTFRPAA MLVERSTDYG HNWKVFKYFA KDCATSFPNI TSGQAQGVGD 190 200 210 220 230 240 IVCDSKYSDI EPSTGGEVVL KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLHTLGDAL 250 260 270 280 290 300 LGRRQNDSLD KYYYALYEMI VRGSCFCNGH ASECRPMQKM RGDVFSPPGM VHGQCVCQHN 310 320 330 340 350 360 TDGPNCERCK DFFQDAPWRP AADLQDNACR SCSCNSHSSR CHFDMTTYLA SGGLSGGVCE 370 380 390 400 410 420 DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD GTISGGICVS HSDPALGSVA 430 440 450 460 470 480 GQCLCKENVE GAKCDQCKPN HYGLSATDPL GCQPCDCNPL GSLPFLTCDV DTGQCLCLSY 490 500 510 520 530 540 VTGAHCEECT VGYWGLGNHL HGCSPCDCDI GGAYSNVCSP KNGQCECRPH VTGRSCSEPA 550 560 570 580 590 600 PGYFFAPLNF YLYEAEEATT LQGLAPLGSE TFGQSPAVHV VLGEPVPGNP VTWTGPGFAR 610 620 630 640 650 660 VLPGAGLRFA VNNIPFPVDF TIAIHYETQS AADWTVQIVV NPPGGSEHCI PKTLQSKPQS 670 680 690 700 710 720 FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLQGESHA HSHVLVDSLG LIPQINSLEN 730 740 750 760 770 780 FCSKQDLDEY QLHNCVEIAS AMGPQVLPGA CERLIISMSA KLHDGAVACK CHPQGSVGSS 790 800 810 820 830 840 CSRLGGQCQC KPLVVGRCCD RCSTGSYDLG HHGCHPCHCH PQGSKDTVCD QVTGQCPCHG 850 860 870 880 890 900 EVSGRRCDRC LAGYFGFPSC HPCPCNRFAE LCDPETGSCF NCGGFTTGRN CERCIDGYYG 910 920 930 940 950 960 NPSSGQPCRP CLCPDDPSSN QYFAHSCYQN LWSSDVICNC LQGYTGTQCG ECSTGFYGNP 970 980 990 1000 1010 1020 RISGAPCQPC ACNNNIDVTD PESCSRVTGE CLRCLHNTQG ANCQLCKPGH YGSALNQTCR 1030 1040 1050 1060 1070 1080 RCSCHASGVS PMECPPGGGA CLCDPVTGAC PCLPNVTGLA CDRCADGYWN LVPGRGCQSC 1090 1100 1110 1120 1130 1140 DCDPRTSQSS HCDQLTGQCP CKLGYGGKRC SECQENYYGD PPGRCIPCDC NRAGTQKPIC 1150 1160 1170 1180 1190 1200 DPDTGMCRCR EGVSGQRCDR CARGHSQEFP TCLQCHLCFD QWDHTISSLS KAVQGLMRLA 1210 1220 1230 1240 1250 1260 ANMEDKRETL PVCEADFKDL RGNVSEIERI LKHPVFPSGK FLKVKDYHDS VRRQIMQLNE 1270 1280 1290 1300 1310 1320 QLKAVYEFQD LKDTIERAKN EADLLLEDLQ EEIDLQSSVL NASIADSSEN IKKYYHISSS 1330 1340 1350 1360 1370 1380 AEKKINETSS TINTSANTRN DLLTILDTLT SKGNLSLERL KQIKIPDIQI LNEKVCGDPG 1390 1400 1410 1420 1430 1440 NVPCVPLPCG GALCTGRKGH RKCRGPGCHG SLTLSTNALQ KAQEAKSIIR NLDKQVRGLK 1450 1460 1470 1480 1490 1500 NQIESISEQA EVSKNNALQL REKLGNIRNQ SDSEEENINL FIKKVKNFLL EENVPPEDIE 1510 1520 1530 1540 1550 1560 KVANGVLDIH LPIPSQNLTD ELVKIQKHMQ LCEDYRTDEN RLNEEADGAQ KLLVKAKAAE 1570 1580 1590 1600 1610 1620 KAANILLNLD KTLNQLQQAQ ITQGRANSTI TQLTANITKI KKNVLQAENQ TREMKSELEL 1630 1640 1650 1660 1670 1680 AKQRSGLEDG LSLLQTKLQR HQDHAVNAKV QAESAQHQAG SLEKEFVELK KQYAILQRKT 1690 1700 1710 1720 STTGLTKETL GKVKQLKDAA EKLAGDTEAK IRRITGCFQN SAR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human laminin beta-4 chain." Olson P.F., Koch M., Champliaud M.F., Rowland K., Jin W., Burgeson R.E. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 975-1761 (ISOFORM 3). Tissue: Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1528-1761 (ISOFORM 1). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF028816 mRNA. Translation: AAC95123.1. AC005048 Genomic DNA. No translation available. CH236947 Genomic DNA. Translation: EAL24387.1. BC045172 mRNA. Translation: AAH45172.2. BC140804 mRNA. Translation: AAI40805.1. BC142619 mRNA. Translation: AAI42620.1. AK075165 mRNA. No translation available.
IPI	IPI00295437. IPI00852842. IPI00927194.
RefSeq	NP_031382.2. NM_007356.2.
UniGene	Hs.62022.
3D structure databases
ProteinModelPortal	A4D0S4.
SMR	A4D0S4. Positions 26-545, 786-1170.
ModBase	Search...
Protein-protein interaction databases
IntAct	A4D0S4. 1 interaction.
STRING	A4D0S4.
Proteomic databases
PRIDE	A4D0S4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000205386; ENSP00000205386; ENSG00000091128. ENST00000388781; ENSP00000373433; ENSG00000091128.
GeneID	22798.
KEGG	hsa:22798.
UCSC	uc003vey.2. human.
Organism-specific databases
CTD	22798.
GeneCards	GC07M107663.
HGNC	HGNC:6491. LAMB4.
neXtProt	NX_A4D0S4.
PharmGKB	PA30279.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG358340.
HOVERGEN	HBG052301.
OMA	CSRLGGQ.
OrthoDB	EOG46DM1W.
PhylomeDB	A4D0S4.
Gene expression databases
Bgee	A4D0S4.
CleanEx	HS_LAMB4.
Genevestigator	A4D0S4.
Family and domain databases
InterPro	IPR013032. EGF-like_reg_CS. IPR002049. EGF_laminin. IPR013015. Laminin_IV. IPR008211. Laminin_N. [Graphical view]
KO	K06245.
Pfam	PF00053. Laminin_EGF. 12 hits. PF00055. Laminin_N. 1 hit. [Graphical view]
SMART	SM00180. EGF_Lam. 13 hits. SM00136. LamNT. 1 hit. [Graphical view]
PROSITE	PS00022. EGF_1. 10 hits. PS01186. EGF_2. 2 hits. PS01248. EGF_LAM_1. 11 hits. PS50027. EGF_LAM_2. 13 hits. PS51116. LAMININ_IVB. 1 hit. PS51117. LAMININ_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43142.

Entry information

Entry name

LAMB4_HUMAN

Accession

Primary (citable) accession number: A4D0S4
Secondary accession number(s): A5PKU6 , B2RTT3, B5MEB9, Q86TP7, Q86XN2, Q8NBX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.