ID   GPR22_HUMAN             Reviewed;         433 AA.
AC   Q99680; A4D0R8; O14554;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=G-protein coupled receptor 22;
GN   Name=GPR22 {ECO:0000312|HGNC:HGNC:4477};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=9073069; DOI=10.1016/s0378-1119(96)00722-6;
RA   O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q.,
RA   Kolakowski L.F. Jr., Lynch K.R., George S.R.;
RT   "Cloning and chromosomal mapping of four putative novel human G-protein-
RT   coupled receptor genes.";
RL   Gene 187:75-81(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.;
RT   "Isolation of cDNA coding for three human genes.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [6]
RP   TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=18539757; DOI=10.1152/ajpheart.00368.2008;
RA   Adams J.W., Wang J., Davis J.R., Liaw C., Gaidarov I., Gatlin J.,
RA   Dalton N.D., Gu Y., Ross J. Jr., Behan D., Chien K., Connolly D.;
RT   "Myocardial expression, signaling, and function of GPR22: a protective role
RT   for an orphan G protein-coupled receptor.";
RL   Am. J. Physiol. 295:H509-H521(2008).
CC   -!- FUNCTION: Orphan G-protein coupled receptor. Seems to act through a
CC       G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in
CC       ciliogenesis (By similarity). {ECO:0000250|UniProtKB:A0A2R9YJI3,
CC       ECO:0000269|PubMed:18539757}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D4A3U0};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: High expression in adult and fetal heart tissue
CC       (PubMed:18539757). Expressed in the brain, with enrichment in the
CC       accumbens, amygdala, cerebellum, cortex, and hippocampus regions
CC       (PubMed:9073069, PubMed:18539757). {ECO:0000269|PubMed:18539757,
CC       ECO:0000269|PubMed:9073069}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U66581; AAC51304.1; -; Genomic_DNA.
DR   EMBL; HQ995527; ADZ31972.1; -; mRNA.
DR   EMBL; AC002381; AAB63815.1; -; Genomic_DNA.
DR   EMBL; CH236947; EAL24394.1; -; Genomic_DNA.
DR   EMBL; CH471070; EAW83398.1; -; Genomic_DNA.
DR   CCDS; CCDS5744.1; -.
DR   RefSeq; NP_005286.2; NM_005295.2.
DR   RefSeq; XP_011514358.1; XM_011516056.2.
DR   AlphaFoldDB; Q99680; -.
DR   SMR; Q99680; -.
DR   BioGRID; 109104; 3.
DR   IntAct; Q99680; 4.
DR   MINT; Q99680; -.
DR   STRING; 9606.ENSP00000302676; -.
DR   ChEMBL; CHEMBL4523914; -.
DR   GlyCosmos; Q99680; 2 sites, No reported glycans.
DR   GlyGen; Q99680; 2 sites.
DR   iPTMnet; Q99680; -.
DR   PhosphoSitePlus; Q99680; -.
DR   BioMuta; GPR22; -.
DR   DMDM; 116242502; -.
DR   MassIVE; Q99680; -.
DR   MaxQB; Q99680; -.
DR   PaxDb; 9606-ENSP00000302676; -.
DR   PeptideAtlas; Q99680; -.
DR   ProteomicsDB; 78394; -.
DR   Antibodypedia; 1939; 302 antibodies from 29 providers.
DR   DNASU; 2845; -.
DR   Ensembl; ENST00000304402.6; ENSP00000302676.4; ENSG00000172209.6.
DR   Ensembl; ENST00000639742.2; ENSP00000492841.1; ENSG00000283812.2.
DR   GeneID; 2845; -.
DR   KEGG; hsa:2845; -.
DR   MANE-Select; ENST00000304402.6; ENSP00000302676.4; NM_005295.3; NP_005286.2.
DR   UCSC; uc003vef.4; human.
DR   AGR; HGNC:4477; -.
DR   CTD; 2845; -.
DR   DisGeNET; 2845; -.
DR   GeneCards; GPR22; -.
DR   HGNC; HGNC:4477; GPR22.
DR   HPA; ENSG00000172209; Tissue enhanced (brain, heart muscle).
DR   MIM; 601910; gene.
DR   neXtProt; NX_Q99680; -.
DR   OpenTargets; ENSG00000172209; -.
DR   PharmGKB; PA28865; -.
DR   VEuPathDB; HostDB:ENSG00000172209; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244841; -.
DR   HOGENOM; CLU_057984_0_0_1; -.
DR   InParanoid; Q99680; -.
DR   OMA; VGPSDLM; -.
DR   OrthoDB; 2953289at2759; -.
DR   PhylomeDB; Q99680; -.
DR   TreeFam; TF318505; -.
DR   PathwayCommons; Q99680; -.
DR   SignaLink; Q99680; -.
DR   BioGRID-ORCS; 2845; 14 hits in 1132 CRISPR screens.
DR   GeneWiki; GPR22; -.
DR   GenomeRNAi; 2845; -.
DR   Pharos; Q99680; Tbio.
DR   PRO; PR:Q99680; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q99680; Protein.
DR   Bgee; ENSG00000172209; Expressed in cortical plate and 87 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IMP:UniProtKB.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24241:SF1; G-PROTEIN COUPLED RECEPTOR 22; 1.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 2.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q99680; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cilium biogenesis/degradation; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..433
FT                   /note="G-protein coupled receptor 22"
FT                   /id="PRO_0000069543"
FT   TOPO_DOM        1..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        46..66
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        86..106
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..115
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        116..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        209..229
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        316..336
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        337..349
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        350..370
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        371..433
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        192
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        425
FT                   /note="C -> R (in Ref. 1; AAC51304)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  49265 MW;  2D4DC8AC567C4DC1 CRC64;
     MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL
     TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA
     CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN
     FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI
     RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR
     HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT
     IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE
     IREKCLVPQV VTD
//