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Protein
Submitted name:

G protein-coupled receptor 22

Gene

GPR22

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
G protein-coupled receptor 22Imported
Submitted name:
HCG1645679Imported
Gene namesi
Name:GPR22Imported
ORF Names:hCG_1645679Imported, tcag7.108Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 66HelicalSequence analysisAdd BLAST27
Transmembranei86 – 105HelicalSequence analysisAdd BLAST20
Transmembranei111 – 136HelicalSequence analysisAdd BLAST26
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Transmembranei311 – 332HelicalSequence analysisAdd BLAST22
Transmembranei344 – 369HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28865.

Expressioni

Gene expression databases

BgeeiENSG00000172209.
ExpressionAtlasiA4D0R8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302676.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 367G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST310

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG051802.
KOiK04319.
OMAiRAVMLMT.
OrthoDBiEOG091G08FB.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4D0R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML
60 70 80 90 100
EIVLGLGSNL TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI
110 120 130 140 150
VILLLSLESN TALICCFHEA CVSFASVSTA INVFAITLDR YDISVKPANR
160 170 180 190 200
ILTMGRAVML MISIWIFSFF SFLIPFIEVN FFSLQSGNTW ENKTLLCVST
210 220 230 240 250
NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI RIGTRFSTGQ
260 270 280 290 300
KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR
310 320 330 340 350
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL
360 370 380 390 400
CFLVMAYGTT IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV
410 420 430
IHNSWIDPKR NKKITFEDSE IREKCLVPQV VTD
Length:433
Mass (Da):49,265
Last modified:April 3, 2007 - v1
Checksum:i2D4DC8AC567C4DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ995527 mRNA. Translation: ADZ31972.1.
CH236947 Genomic DNA. Translation: EAL24394.1.
CH471070 Genomic DNA. Translation: EAW83398.1.
RefSeqiNP_005286.2. NM_005295.2.
XP_011514358.1. XM_011516056.2.
UniGeneiHs.657277.

Genome annotation databases

GeneIDi2845.
KEGGihsa:2845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ995527 mRNA. Translation: ADZ31972.1.
CH236947 Genomic DNA. Translation: EAL24394.1.
CH471070 Genomic DNA. Translation: EAW83398.1.
RefSeqiNP_005286.2. NM_005295.2.
XP_011514358.1. XM_011516056.2.
UniGeneiHs.657277.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2845.
KEGGihsa:2845.

Organism-specific databases

CTDi2845.
PharmGKBiPA28865.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG051802.
KOiK04319.
OMAiRAVMLMT.
OrthoDBiEOG091G08FB.

Miscellaneous databases

GenomeRNAii2845.

Gene expression databases

BgeeiENSG00000172209.
ExpressionAtlasiA4D0R8. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA4D0R8_HUMAN
AccessioniPrimary (citable) accession number: A4D0R8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.