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Protein

tRNA-dihydrouridine synthase

Gene

PP35

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116Proton donorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processtRNA processingUniRule annotation
LigandFlavoprotein, FMNUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine synthaseUniRule annotation (EC:1.3.1.-UniRule annotation)
Gene namesi
Name:PP35Imported
Synonyms:DUS4LImported
ORF Names:hCG_16934Imported, tcag7.44Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000105865.10

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671939

Expressioni

Gene expression databases

BgeeiENSG00000105865

Family & Domainsi

Sequence similaritiesi

Belongs to the dus family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2335 Eukaryota
COG0042 LUCA
HOVERGENiHBG053313
KOiK05545
OMAiTFIIHAR
OrthoDBiEOG091G0EQJ

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
PANTHERiPTHR11082 PTHR11082, 1 hit
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PIRSFiPIRSF006621 Dus, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit

Sequencei

Sequence statusi: Complete.

A4D0R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDCMQTTI CQERKKDPIE MFHSGQLVKV CAPMVRYSKL AFRTLVRKYS
60 70 80 90 100
CDLCYTPMIV AADFVKSIKA RDSEFTTNQG DCPLIVQFAA NDARLLSDAA
110 120 130 140 150
RIVCPYANGI DINCGCPQRW AMAEGYGACL INKPELVQDM VKQVRNQVET
160 170 180 190 200
PGFSVSIKIR IHDDLKRTVD LCQKAEATGV SWITVHGRTA EERHQPVHYD
210 220 230 240 250
SIKIIKENMS IPVIANGDIR SLKEAENVWR ITGTDGVMVA RGLLANPAMF
260 270 280 290 300
AGYEETPLKC IWDWVDIALE LGTPYMCFHQ HLMYMMEKIT SRQEKRVFNA
310
LSSTSAIIDY LTDHYGI
Length:317
Mass (Da):35,816
Last modified:April 3, 2007 - v1
Checksum:i52A8AF158275B3BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236947 Genomic DNA Translation: EAL24391.1
CH471070 Genomic DNA Translation: EAW83401.1
CH471070 Genomic DNA Translation: EAW83402.1
CH471070 Genomic DNA Translation: EAW83404.1
RefSeqiNP_001257348.1, NM_001270419.1
NP_853559.1, NM_181581.2
XP_005250182.1, XM_005250125.4
XP_011514068.1, XM_011515766.2
XP_011514069.1, XM_011515767.2
XP_016867197.1, XM_017011708.1
UniGeneiHs.97627

Genome annotation databases

GeneIDi11062
KEGGihsa:11062

Similar proteinsi

Entry informationi

Entry nameiA4D0R5_HUMAN
AccessioniPrimary (citable) accession number: A4D0R5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health