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Protein

Thymidine kinase

Gene

tdk

Organism
Robiginitalea biformata (strain ATCC BAA-864 / HTCC2501 / KCTC 12146)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRBIF313596:G1GFS-801-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:RB2501_07405Imported
OrganismiRobiginitalea biformata (strain ATCC BAA-864 / HTCC2501 / KCTC 12146)Imported
Taxonomic identifieri313596 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeRobiginitalea
Proteomesi
  • UP000009049 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi313596.RB2501_07405

Structurei

3D structure databases

ProteinModelPortaliA4CIF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A4CIF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLENTVNPK EQFGWIEVIC GSMFSGKTEE LIRRLRRAQF ARQKVEIFKP
60 70 80 90 100
IVDTRYHEDY VVSHDENEIR STPVPAAANI RLLADNCDVV GIDEAQFFDD
110 120 130 140 150
EIVTVCNDLA NKGVRVVVAG LDMDFKGNPF GPMPALMATA EYVTKVHAIC
160 170 180 190 200
TRTGNLANYS YRKSRNDRLV LLGETEEYEP LSRGAFYKAM LTEKISKLEV
210
NEPEVLPSKK SENASKP
Length:217
Mass (Da):24,511
Last modified:April 3, 2007 - v1
Checksum:iC3E7A7A3AA7A9D73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001712 Genomic DNA Translation: EAR16709.1
RefSeqiWP_015753466.1, NC_013222.1

Genome annotation databases

EnsemblBacteriaiEAR16709; EAR16709; RB2501_07405
KEGGirbi:RB2501_07405

Similar proteinsi

Entry informationi

Entry nameiA4CIF1_ROBBH
AccessioniPrimary (citable) accession number: A4CIF1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health