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A4CIF1

- A4CIF1_ROBBH

UniProt

A4CIF1 - A4CIF1_ROBBH

Protein

Thymidine kinase

Gene

tdk

Organism
Robiginitalea biformata (strain ATCC BAA-864 / HTCC2501 / KCTC 12146)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 288ATPUniRule annotation
    Nucleotide bindingi93 – 964ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRBIF313596:GH7G-830-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:RB2501_07405Imported
    OrganismiRobiginitalea biformata (strain ATCC BAA-864 / HTCC2501 / KCTC 12146)Imported
    Taxonomic identifieri313596 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeRobiginitalea
    ProteomesiUP000009049: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi313596.RB2501_07405.

    Structurei

    3D structure databases

    ProteinModelPortaliA4CIF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4CIF1-1 [UniParc]FASTAAdd to Basket

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    MFLENTVNPK EQFGWIEVIC GSMFSGKTEE LIRRLRRAQF ARQKVEIFKP    50
    IVDTRYHEDY VVSHDENEIR STPVPAAANI RLLADNCDVV GIDEAQFFDD 100
    EIVTVCNDLA NKGVRVVVAG LDMDFKGNPF GPMPALMATA EYVTKVHAIC 150
    TRTGNLANYS YRKSRNDRLV LLGETEEYEP LSRGAFYKAM LTEKISKLEV 200
    NEPEVLPSKK SENASKP 217
    Length:217
    Mass (Da):24,511
    Last modified:April 3, 2007 - v1
    Checksum:iC3E7A7A3AA7A9D73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001712 Genomic DNA. Translation: EAR16709.1.
    RefSeqiYP_003194488.1. NC_013222.1.

    Genome annotation databases

    EnsemblBacteriaiEAR16709; EAR16709; RB2501_07405.
    GeneIDi8455182.
    KEGGirbi:RB2501_07405.
    PATRICi23332997. VBIRobBif55773_0777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001712 Genomic DNA. Translation: EAR16709.1 .
    RefSeqi YP_003194488.1. NC_013222.1.

    3D structure databases

    ProteinModelPortali A4CIF1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 313596.RB2501_07405.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAR16709 ; EAR16709 ; RB2501_07405 .
    GeneIDi 8455182.
    KEGGi rbi:RB2501_07405.
    PATRICi 23332997. VBIRobBif55773_0777.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci RBIF313596:GH7G-830-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Robiginitalea biformata HTCC2501."
      Oh H.M., Giovannoni S.J., Lee K., Ferriera S., Johnson J., Cho J.C.
      J. Bacteriol. 191:7144-7145(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-864 / HTCC2501 / KCTC 12146Imported.

    Entry informationi

    Entry nameiA4CIF1_ROBBH
    AccessioniPrimary (citable) accession number: A4CIF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3