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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Polaribacter irgensii 23-P
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 187ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotationSAAS annotation
Gene namesi
Name:dnaAUniRule annotationImported
ORF Names:PI23P_00100Imported
OrganismiPolaribacter irgensii 23-PImported
Taxonomic identifieri313594 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaePolaribacter
Proteomesi
  • UP000003053 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi313594.PI23P_00100.

Structurei

3D structure databases

ProteinModelPortaliA4C2N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 308AAAInterPro annotationAdd BLAST137
Domaini383 – 452Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF12. PTHR30050:SF12. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiView protein in PROSITE
PS01008. DNAA. 1 hit.

Sequencei

Sequence statusi: Complete.

A4C2N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSSESVWN ECLIFIKDNI KPQAYKTWFE PIKPVKLSGE SLTIQVPSKF
60 70 80 90 100
FYEWLEEHYI KLLRVALVRQ LGSDAKLIYD VKMENNYSSN RPQIVKIPSS
110 120 130 140 150
NRNPLKPQNV TVSLDSGKRE LRNPFVIPGL QKVKIESQLN PNYNFANFVE
160 170 180 190 200
GDSNRLARSA GMAVANKPGG TSFNPLLIYG GVGLGKTHLS HAIGVDIKDK
210 220 230 240 250
YPDKTVLYIS SEKFTQQFID SVKSNTRNDF IHFYQMIDVL IIDDVQFLSG
260 270 280 290 300
KAGTQDVFFH IFNHLHQNGK QVILTSDKAP VDMQDIEQRL LSRFKWGLSA
310 320 330 340 350
ELQAPDYETR ISILQNKLFR DGVEMPEDIV GYIAKNIKSN VRELEGVIIS
360 370 380 390 400
MIAQASFNRR EFSLELAKQI VDKFVKNTKK EVSIDYIQKE VSKYFDMDVA
410 420 430 440 450
TLQSKTRKRH IVQARQLAMF FAKRLTKTSL ASIGNQIGQR DHATVLHACK
460 470
TVDNLTETDK QFRKYVDDLT KKLTF
Length:475
Mass (Da):54,329
Last modified:April 3, 2007 - v1
Checksum:i2139D0AD07CF3E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAOG01000005 Genomic DNA. Translation: EAR11560.1.
RefSeqiWP_004568637.1. NZ_CH724148.1.

Genome annotation databases

EnsemblBacteriaiEAR11560; EAR11560; PI23P_00100.

Similar proteinsi

Entry informationi

Entry nameiA4C2N6_9FLAO
AccessioniPrimary (citable) accession number: A4C2N6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 27, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported