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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Maribacter sp. (strain HTCC2170 / KCCM 42371)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathway: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathway: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSP313603:GH3X-1970-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotationSAAS annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:FB2170_08559Imported
OrganismiMaribacter sp. (strain HTCC2170 / KCCM 42371)Imported
Taxonomic identifieri313603 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeMaribacter
ProteomesiUP000001602 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi313603.FB2170_08559.

Structurei

3D structure databases

ProteinModelPortaliA4AU92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230373.
KOiK00602.
OMAiPCGVAEG.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.

Sequencei

Sequence statusi: Complete.

A4AU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKKATSAL ISVFHKDGLE PIVKKFNELG ITIYSTGGTE KFIKDLGIDV
60 70 80 90 100
VPVEDVTSYP SILGGRVKTL HPKVFGGILN RQDHDGDVAQ LEEFEIPQLD
110 120 130 140 150
IVIVDLYPFE KTMASGASEQ DIIEKIDIGG ISLIRAAAKN FKDVLCVSSM
160 170 180 190 200
EDYAEVLELI TNGNGSTTIE DRKRFATKSF NVSSHYDSAI FNYFNANHEE
210 220 230 240 250
AALKISETKG KVLRYGENPH QKGFFFGDFD AMFNKLHGKE LSYNNLLDVD
260 270 280 290 300
AAVNLMNEFK NDDPTFAILK HNNACGLAMR DTLHQAYVDA LAGDPVSAFG
310 320 330 340 350
GVLISNKEID KATAEEIHKL FCEVVIAPSY ADDALEILKG KKNRIILIQN
360 370 380 390 400
DVELPHNQVR TCLNGVLLQD KDHKTDSLED LNTATNNSPS QREVEDLIFA
410 420 430 440 450
SKLCKHTKSN TIVLAKNKQL CASGTGQTSR VDALNQAIHK AKSFNFDLQD
460 470 480 490 500
AVMASDAFFP FPDCVEIAHK SGITSVIQPG GSIKDQLSID YCNENNIAMV

MTGTRHFKH
Length:509
Mass (Da):56,113
Last modified:April 3, 2007 - v1
Checksum:i2992A50C4C2D78AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA. Translation: EAR00543.1.
RefSeqiWP_013306368.1. NC_014472.1.
YP_003862601.1. NC_014472.1.

Genome annotation databases

EnsemblBacteriaiEAR00543; EAR00543; FB2170_08559.
KEGGifbc:FB2170_08559.
PATRICi42333459. VBIFlaBac16383_1986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA. Translation: EAR00543.1.
RefSeqiWP_013306368.1. NC_014472.1.
YP_003862601.1. NC_014472.1.

3D structure databases

ProteinModelPortaliA4AU92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi313603.FB2170_08559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEAR00543; EAR00543; FB2170_08559.
KEGGifbc:FB2170_08559.
PATRICi42333459. VBIFlaBac16383_1986.

Phylogenomic databases

HOGENOMiHOG000230373.
KOiK00602.
OMAiPCGVAEG.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.
BioCyciMSP313603:GH3X-1970-MONOMER.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of strain HTCC2170, a novel member of the genus Maribacter in the family Flavobacteriaceae."
    Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J., Cho J.C.
    J. Bacteriol. 193:303-304(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC2170 / KCCM 42371Imported.

Entry informationi

Entry nameiA4AU92_MARSH
AccessioniPrimary (citable) accession number: A4AU92
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 24, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.