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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Maribacter sp. (strain HTCC2170 / KCCM 42371)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported, Multifunctional enzymeUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotationImported
Biological processPurine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSP313603:G1GNS-1938-MONOMER
UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
InosinicaseUniRule annotation
IMP synthaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:FB2170_08559Imported
OrganismiMaribacter sp. (strain HTCC2170 / KCCM 42371)Imported
Taxonomic identifieri313603 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeMaribacter
Proteomesi
  • UP000001602 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi313603.FB2170_08559

Structurei

3D structure databases

ProteinModelPortaliA4AU92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 132MGSInterPro annotationAdd BLAST115

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DC1 Bacteria
COG0138 LUCA
HOGENOMiHOG000230373
KOiK00602
OMAiDLLFAWK
OrthoDBiPOG091H00UT

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit

Sequencei

Sequence statusi: Complete.

A4AU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKKATSAL ISVFHKDGLE PIVKKFNELG ITIYSTGGTE KFIKDLGIDV
60 70 80 90 100
VPVEDVTSYP SILGGRVKTL HPKVFGGILN RQDHDGDVAQ LEEFEIPQLD
110 120 130 140 150
IVIVDLYPFE KTMASGASEQ DIIEKIDIGG ISLIRAAAKN FKDVLCVSSM
160 170 180 190 200
EDYAEVLELI TNGNGSTTIE DRKRFATKSF NVSSHYDSAI FNYFNANHEE
210 220 230 240 250
AALKISETKG KVLRYGENPH QKGFFFGDFD AMFNKLHGKE LSYNNLLDVD
260 270 280 290 300
AAVNLMNEFK NDDPTFAILK HNNACGLAMR DTLHQAYVDA LAGDPVSAFG
310 320 330 340 350
GVLISNKEID KATAEEIHKL FCEVVIAPSY ADDALEILKG KKNRIILIQN
360 370 380 390 400
DVELPHNQVR TCLNGVLLQD KDHKTDSLED LNTATNNSPS QREVEDLIFA
410 420 430 440 450
SKLCKHTKSN TIVLAKNKQL CASGTGQTSR VDALNQAIHK AKSFNFDLQD
460 470 480 490 500
AVMASDAFFP FPDCVEIAHK SGITSVIQPG GSIKDQLSID YCNENNIAMV

MTGTRHFKH
Length:509
Mass (Da):56,113
Last modified:April 3, 2007 - v1
Checksum:i2992A50C4C2D78AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA Translation: EAR00543.1
RefSeqiWP_013306368.1, NC_014472.1

Genome annotation databases

EnsemblBacteriaiEAR00543; EAR00543; FB2170_08559
KEGGifbc:FB2170_08559

Similar proteinsi

Entry informationi

Entry nameiA4AU92_MARSH
AccessioniPrimary (citable) accession number: A4AU92
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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