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A4ATE1

- A4ATE1_MARSH

UniProt

A4ATE1 - A4ATE1_MARSH

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Protein

Kynurenine 3-monooxygenase

Gene

kmo

Organism
Maribacter sp. (strain HTCC2170 / KCCM 42371)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

Note: FAD.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  2. kynurenine 3-monooxygenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotationImported, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMSP313603:GH3X-87-MONOMER.
UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:kmoUniRule annotation
Ordered Locus Names:FB2170_16541Imported
OrganismiMaribacter sp. (strain HTCC2170 / KCCM 42371)Imported
Taxonomic identifieri313603 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeMaribacter
ProteomesiUP000001602: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA4ATE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251788.
KOiK00486.
OMAiMNRRRER.

Family and domain databases

HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.

Sequencei

Sequence statusi: Complete.

A4ATE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQTSKNIAI VGSGLVGSLL AIYLRKLGHA ITVFDRRPDI RTIEFSGRSI
60 70 80 90 100
NLAMSNRGWR ALDEIGIEEE IKKIAIPLDK RAMHVVGKPM YFQHYGEEGE
110 120 130 140 150
AIWSISRGVL NRKMIDLAEE AGVKFKFEEK VWDVDLPAAK LQTGETEKGE
160 170 180 190 200
WKEYAYDLIF GCDGAFSRIR HKMQRRSRFD YSQDFIDVGY KELTIPANSD
210 220 230 240 250
GSHKLDANSF HIWPRGRFMF IAMPNIDGSF TCTLFMPFEG DISFESIRTH
260 270 280 290 300
EEARTFFRTH FPSVDQEIEN LAHDFFKNPT SAMVTMKCYP WTYWDKVALV
310 320 330 340 350
GDSAHAIVPF YGQGMNAGFE DIFVLNKIIK EEGDNWEAIF QQYQKKRKPN
360 370 380 390 400
ADAIAELSYR NFMEMSSKTA DPKFLMQKKI EKRFAQKYPD KWVPLYSRVT
410 420 430 440
FSHRPYSEAL AIGNAQEKIM SQIMDFPDIE KKWDSDEIEQ EILNMLP
Length:447
Mass (Da):51,706
Last modified:April 3, 2007 - v1
Checksum:iC9FE092A7DF82B8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA. Translation: EAR00711.1.
RefSeqiWP_013304514.1. NC_014472.1.
YP_003860745.1. NC_014472.1.

Genome annotation databases

EnsemblBacteriaiEAR00711; EAR00711; FB2170_16541.
GeneIDi9717443.
KEGGifbc:FB2170_16541.
PATRICi42329605. VBIFlaBac16383_0082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA. Translation: EAR00711.1 .
RefSeqi WP_013304514.1. NC_014472.1.
YP_003860745.1. NC_014472.1.

3D structure databases

ProteinModelPortali A4ATE1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EAR00711 ; EAR00711 ; FB2170_16541 .
GeneIDi 9717443.
KEGGi fbc:FB2170_16541.
PATRICi 42329605. VBIFlaBac16383_0082.

Phylogenomic databases

HOGENOMi HOG000251788.
KOi K00486.
OMAi MNRRRER.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00328 .
BioCyci MSP313603:GH3X-87-MONOMER.

Family and domain databases

HAMAPi MF_01971. Kynurenine_monooxygenase.
InterProi IPR027545. Kynurenine_monooxygenase.
IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of strain HTCC2170, a novel member of the genus Maribacter in the family Flavobacteriaceae."
    Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J., Cho J.C.
    J. Bacteriol. 193:303-304(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC2170 / KCCM 42371Imported.

Entry informationi

Entry nameiA4ATE1_MARSH
AccessioniPrimary (citable) accession number: A4ATE1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3