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A4ATE1

- A4ATE1_MARSH

UniProt

A4ATE1 - A4ATE1_MARSH

Protein

Kynurenine 3-monooxygenase

Gene

kmo

Organism
Maribacter sp. (strain HTCC2170 / KCCM 42371)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

    Catalytic activityi

    L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    2. kynurenine 3-monooxygenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    MonooxygenaseUniRule annotationImported, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    FADUniRule annotation, Flavoprotein, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciMSP313603:GH3X-87-MONOMER.
    UniPathwayiUPA00253; UER00328.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
    Alternative name(s):
    Kynurenine 3-hydroxylaseUniRule annotation
    Gene namesi
    Name:kmoUniRule annotation
    Ordered Locus Names:FB2170_16541Imported
    OrganismiMaribacter sp. (strain HTCC2170 / KCCM 42371)Imported
    Taxonomic identifieri313603 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeMaribacter
    ProteomesiUP000001602: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliA4ATE1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000251788.
    KOiK00486.
    OMAiMNRRRER.

    Family and domain databases

    HAMAPiMF_01971. Kynurenine_monooxygenase.
    InterProiIPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view]
    PfamiPF01494. FAD_binding_3. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.

    Sequencei

    Sequence statusi: Complete.

    A4ATE1-1 [UniParc]FASTAAdd to Basket

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    MSQTSKNIAI VGSGLVGSLL AIYLRKLGHA ITVFDRRPDI RTIEFSGRSI    50
    NLAMSNRGWR ALDEIGIEEE IKKIAIPLDK RAMHVVGKPM YFQHYGEEGE 100
    AIWSISRGVL NRKMIDLAEE AGVKFKFEEK VWDVDLPAAK LQTGETEKGE 150
    WKEYAYDLIF GCDGAFSRIR HKMQRRSRFD YSQDFIDVGY KELTIPANSD 200
    GSHKLDANSF HIWPRGRFMF IAMPNIDGSF TCTLFMPFEG DISFESIRTH 250
    EEARTFFRTH FPSVDQEIEN LAHDFFKNPT SAMVTMKCYP WTYWDKVALV 300
    GDSAHAIVPF YGQGMNAGFE DIFVLNKIIK EEGDNWEAIF QQYQKKRKPN 350
    ADAIAELSYR NFMEMSSKTA DPKFLMQKKI EKRFAQKYPD KWVPLYSRVT 400
    FSHRPYSEAL AIGNAQEKIM SQIMDFPDIE KKWDSDEIEQ EILNMLP 447
    Length:447
    Mass (Da):51,706
    Last modified:April 3, 2007 - v1
    Checksum:iC9FE092A7DF82B8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002157 Genomic DNA. Translation: EAR00711.1.
    RefSeqiWP_013304514.1. NC_014472.1.
    YP_003860745.1. NC_014472.1.

    Genome annotation databases

    EnsemblBacteriaiEAR00711; EAR00711; FB2170_16541.
    GeneIDi9717443.
    KEGGifbc:FB2170_16541.
    PATRICi42329605. VBIFlaBac16383_0082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002157 Genomic DNA. Translation: EAR00711.1 .
    RefSeqi WP_013304514.1. NC_014472.1.
    YP_003860745.1. NC_014472.1.

    3D structure databases

    ProteinModelPortali A4ATE1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAR00711 ; EAR00711 ; FB2170_16541 .
    GeneIDi 9717443.
    KEGGi fbc:FB2170_16541.
    PATRICi 42329605. VBIFlaBac16383_0082.

    Phylogenomic databases

    HOGENOMi HOG000251788.
    KOi K00486.
    OMAi MNRRRER.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00328 .
    BioCyci MSP313603:GH3X-87-MONOMER.

    Family and domain databases

    HAMAPi MF_01971. Kynurenine_monooxygenase.
    InterProi IPR027545. Kynurenine_monooxygenase.
    IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    [Graphical view ]
    Pfami PF01494. FAD_binding_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of strain HTCC2170, a novel member of the genus Maribacter in the family Flavobacteriaceae."
      Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J., Cho J.C.
      J. Bacteriol. 193:303-304(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTCC2170 / KCCM 42371Imported.

    Entry informationi

    Entry nameiA4ATE1_MARSH
    AccessioniPrimary (citable) accession number: A4ATE1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3