tuf

Functionⁱ

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	19 – 26	GTPUniRule annotation	8
Nucleotide bindingⁱ	81 – 85	GTPUniRule annotation	5
Nucleotide bindingⁱ	136 – 139	GTPUniRule annotation	4

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-UniRule
translation elongation factor activity Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	Elongation factorUniRule annotationImported
Biological process	Protein biosynthesis
Ligand	GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongation factor TuUniRule annotation Short name: EF-TuUniRule annotation
Gene namesⁱ	Name:tufUniRule annotation Ordered Locus Names:FB2170_16216Imported
Organismⁱ	Maribacter sp. (strain HTCC2170 / KCCM 42371)Imported
Taxonomic identifierⁱ	313603 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › FCB group › Bacteroidetes/Chlorobi group › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Maribacter
Proteomesⁱ	UP000001602 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00118

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	313603.FB2170_16216.

STRINGⁱ

313603.FB2170_16216.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A4AT76.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 204	Tr-type GInterPro annotationAdd BLAST		195

Sequence similaritiesⁱ

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CGV. Bacteria. COG0050. LUCA.
HOGENOMⁱ	HOG000229290.
KEGG Orthology (KO) More...KOⁱ	K02358.
OMAⁱ	YGHIDCP.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00LA.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03697. EFTU_II. 1 hit.
HAMAPⁱ	MF_00118_B. EF_Tu_B. 1 hit.
InterProⁱ	View protein in InterPro IPR004161. EFTu-like_2. IPR033720. EFTU_2. IPR031157. G_TR_CS. IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR000795. TF_GTP-bd_dom. IPR009000. Transl_B-barrel. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004541. Transl_elong_EFTu/EF1A_bac/org. IPR004160. Transl_elong_EFTu/EF1A_C.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit.
PRINTSⁱ	PR00315. ELONGATNFCT.
SUPFAMⁱ	SSF50447. SSF50447. 1 hit. SSF50465. SSF50465. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00485. EF-Tu. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00301. G_TR_1. 1 hit. PS51722. G_TR_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A4AT76-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKETFDRSK PHLNIGTIGH VDHGKTTLTA AITTVLANAG LSEKRDFDSI 
        60         70         80         90        100
DNAPEEKERG ITINTSHVEY QTANRHYAHV DCPGHADYVK NMVTGAAQMD 
       110        120        130        140        150
GAILVVAATD GPMPQTREHI LLGRQVGIPR IVVFMNKVDM VDDEELLELV 
       160        170        180        190        200
EMEIRELLSF YEYDGDNGPV VAGSALGALN GEQKWVDTVM ELMTAVDEWI 
       210        220        230        240        250
ELPKRDIDKD FLMPVEDVFT ITGRGTVATG RIETGVANTG DAVDIIGMGA 
       260        270        280        290        300
EKLASTVTGV EMFRKILDRG EAGDNVGILL RGIEKSDISR GMVICKPGSV 
       310        320        330        340        350
KPHAKFEAEV YILKKEEGGR HTPFHNNYRP QFYVRTTDVT GNIALPSGVE 
       360        370        380        390 
MVMPGDNLTI TVDLIQPIAL SVGLRFAIRE GGRTVGAGQV TKIID

Length:395

Mass (Da):43,025

Last modified:April 3, 2007 - v1

Checksum:ⁱ9347EEF2E8BB4DE2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002157 Genomic DNA. Translation: EAR00646.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013304449.1. NC_014472.1.

Genome annotation databases

EnsemblBacteriaⁱ	EAR00646; EAR00646; FB2170_16216.
KEGGⁱ	fbc:FB2170_16216.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A4AT76	P42474 A0A1H1NCE7 A0A1B2YQ27 H6RF70 A0A0V1QSP1 A0A1I9XI26 A0A1H4J9K4 W2USE7 A0A1I6TRW1 A0A1B5ZYX8 +63	Cellulophaga lytica (Cytophaga lytica) Maribacter sp. MAR_2009_60 uncultured bacterium uncultured Flavobacteriia bacterium Maribacter dokdonensis DSW-8 Maribacter sp. 1_2014MBL_MicDiv Maribacter dokdonensis Zhouia amylolytica AD3 Zhouia amylolytica Arenibacter sp. C-21 And more	395	UniRef90_P42474	Cluster: Elongation factor Tu	74

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A4AT76	Q74JU6 C2E605 A0A137PKU3 F4AFC6 V5P3R3 F7SE77 D0R4P5 E3SW22 Q8KMP6 I7KG51 +6804	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) Lactobacillus johnsonii ATCC 33200 Lactobacillus johnsonii Lactobacillus johnsonii DPC 6026 Lactobacillus johnsonii N6.2 Lactobacillus johnsonii pf01 Lactobacillus johnsonii (strain FI9785) Lactobacillus hominis DSM 23910 = CRBIP 24.179 Lactobacillus jensenii Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63) And more	396	UniRef50_Q74JU6	Cluster: Elongation factor Tu	6,815

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP002157 Genomic DNA. Translation: EAR00646.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013304449.1. NC_014472.1.

3D structure databases

ProteinModelPortalⁱ	A4AT76.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	313603.FB2170_16216.

STRINGⁱ

313603.FB2170_16216.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	EAR00646; EAR00646; FB2170_16216.
KEGGⁱ	fbc:FB2170_16216.

Phylogenomic databases

eggNOGⁱ	ENOG4105CGV. Bacteria. COG0050. LUCA.
HOGENOMⁱ	HOG000229290.
KEGG Orthology (KO) More...KOⁱ	K02358.
OMAⁱ	YGHIDCP.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00LA.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03697. EFTU_II. 1 hit.
HAMAPⁱ	MF_00118_B. EF_Tu_B. 1 hit.
InterProⁱ	View protein in InterPro IPR004161. EFTu-like_2. IPR033720. EFTU_2. IPR031157. G_TR_CS. IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR000795. TF_GTP-bd_dom. IPR009000. Transl_B-barrel. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004541. Transl_elong_EFTu/EF1A_bac/org. IPR004160. Transl_elong_EFTu/EF1A_C.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit.
PRINTSⁱ	PR00315. ELONGATNFCT.
SUPFAMⁱ	SSF50447. SSF50447. 1 hit. SSF50465. SSF50465. 1 hit. SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00485. EF-Tu. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00301. G_TR_1. 1 hit. PS51722. G_TR_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A4AT76_MARSH
Accessionⁱ	A4AT76Primary (citable) accession number: A4AT76
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 3, 2007
	Last sequence update:	April 3, 2007
	Last modified:	September 27, 2017
	This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A4AT76 (A4AT76_MARSH)

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Elongation factor Tu

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Functionⁱ

Regions

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A4AT76 (A4AT76_MARSH)

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Elongation factor Tu

tuf

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ