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Protein

Thymidine kinase

Gene

tdk

Organism
Maribacter sp. (strain HTCC2170 / KCCM 42371)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP313603:GH3X-1532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:FB2170_06340Imported
OrganismiMaribacter sp. (strain HTCC2170 / KCCM 42371)Imported
Taxonomic identifieri313603 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeMaribacter
ProteomesiUP000001602 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4APG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A4APG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLENTVNHK EQFGWIEVIC GSMFSGKTEE LIRRLKRAQF AKQKVEIFKP
60 70 80 90 100
MVDKRYHEEM VVSHDANEIR STPVPAAANI RILADTCDVI GIDEAQFFDD
110 120 130 140 150
EIVTVCNDLA NRGVRVIVAG LDMDFKGNPF GPMPALMATA EYVTKVHAVC
160 170 180 190 200
TRTGNLANYS FRKAHNDDLV LLGETGEYEP LSRAAYYKAM LKERVKEIDV
210
DVEEISKAKK DVNG
Length:214
Mass (Da):24,106
Last modified:April 3, 2007 - v1
Checksum:i6AD3BB7C42B54ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA. Translation: EAR02885.1.
RefSeqiWP_013305933.1. NC_014472.1.
YP_003862165.1. NC_014472.1.

Genome annotation databases

EnsemblBacteriaiEAR02885; EAR02885; FB2170_06340.
KEGGifbc:FB2170_06340.
PATRICi42332573. VBIFlaBac16383_1545.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002157 Genomic DNA. Translation: EAR02885.1.
RefSeqiWP_013305933.1. NC_014472.1.
YP_003862165.1. NC_014472.1.

3D structure databases

ProteinModelPortaliA4APG3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEAR02885; EAR02885; FB2170_06340.
KEGGifbc:FB2170_06340.
PATRICi42332573. VBIFlaBac16383_1545.

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Enzyme and pathway databases

BioCyciMSP313603:GH3X-1532-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of strain HTCC2170, a novel member of the genus Maribacter in the family Flavobacteriaceae."
    Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J., Cho J.C.
    J. Bacteriol. 193:303-304(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTCC2170 / KCCM 42371Imported.

Entry informationi

Entry nameiA4APG3_MARSH
AccessioniPrimary (citable) accession number: A4APG3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 1, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.