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A4AFX2

- A4AFX2_9ACTN

UniProt

A4AFX2 - A4AFX2_9ACTN

Protein
Submitted name:

Mandelate racemase/muconate lactonizing enzyme

Gene

A20C1_08358

Organism
marine actinobacterium PHSC20C1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei115 – 1151Phosphate
    Metal bindingi215 – 2151MagnesiumImported
    Metal bindingi215 – 2151Sodium
    Metal bindingi241 – 2411MagnesiumImported
    Metal bindingi241 – 2411Sodium
    Metal bindingi258 – 2581Sodium; via carbonyl oxygen
    Metal bindingi268 – 2681MagnesiumImported
    Metal bindingi268 – 2681Sodium

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    MagnesiumImported, Metal-bindingSAAS annotationImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mandelate racemase/muconate lactonizing enzymeImported
    Gene namesi
    ORF Names:A20C1_08358Imported
    Organismimarine actinobacterium PHSC20C1Imported
    Taxonomic identifieri312284 [NCBI]
    Taxonomic lineageiBacteriaActinobacteria

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MSYX-ray2.50A/B/C/D/E/F20-388[»]
    3NO1X-ray2.16A/B/C/D/E/F2-388[»]
    4H83X-ray2.09A/B/C/D/E/F1-388[»]
    ProteinModelPortaliA4AFX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA4AFX2.

    Family & Domainsi

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProiIPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 1 hit.
    PfamiPF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4AFX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHDQRVHAER DPLDPQAHGL TITRIETIPM VAPLAREFRG SHYHMTHRAT    50
    IVTRVHTDAG IIGEAYTGDE HETMFDIDRI IHEELAPTLI GQDAMAIERL 100
    WDSGYKVTFD ILRDRRLGLV ALAAVNTAIW DAVGKALKMP LWKLWGGYRN 150
    ELPMIAIGGY YGEPLGSIAD EMHNYQELGL AGVKFKVGGL SAAEDAARIT 200
    AAREAAGDDF IICIDANQGY KPAVAVDLSR RIADLNIRWF EEPVEWHNDK 250
    RSMRDVRYQG SVPVCAGQTE FSASGCRDLM ETGAIDVCNF DSSWSGGPTA 300
    WLRTAAIATS YDVQMGHHEE PQVSTHLLAS QPHGTIAECF HPDRDPFWWN 350
    MITNRPKLNN GTLTLSDRPG LGWDLNWDYI DQYRVSKD 388
    Length:388
    Mass (Da):43,439
    Last modified:April 3, 2007 - v1
    Checksum:i32F2FB2DF83FCE2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAOB01000002 Genomic DNA. Translation: EAR25878.1.
    RefSeqiWP_009773310.1. NZ_CH672415.1.

    Genome annotation databases

    EnsemblBacteriaiEAR25878; EAR25878; A20C1_08358.
    PATRICi25922165. VBIMarAct105506_0948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAOB01000002 Genomic DNA. Translation: EAR25878.1 .
    RefSeqi WP_009773310.1. NZ_CH672415.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MSY X-ray 2.50 A/B/C/D/E/F 20-388 [» ]
    3NO1 X-ray 2.16 A/B/C/D/E/F 2-388 [» ]
    4H83 X-ray 2.09 A/B/C/D/E/F 1-388 [» ]
    ProteinModelPortali A4AFX2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EAR25878 ; EAR25878 ; A20C1_08358 .
    PATRICi 25922165. VBIMarAct105506_0948.

    Miscellaneous databases

    EvolutionaryTracei A4AFX2.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProi IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view ]
    PANTHERi PTHR13794. PTHR13794. 1 hit.
    Pfami PF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view ]
    SMARTi SM00922. MR_MLE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Murray A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PHSC20C1Imported.
    2. "Crystal Structure of Mandelate racemase/muconate lactonizing enzyme from a Marine actinobacterium."
      Satyanarayana L., Burley S.K., Swaminathan S.
      Submitted (APR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 20-388.
    3. "Crystal Structure of Mandelate racemase/muconate lactonizing enzyme from a Marine actinobacterium in complex with magnesium."
      Satyanarayana L., Burley S.K., Swaminathan S.
      Submitted (JUN-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) OF 2-388 IN COMPLEX WITH MAGNESIUM.
    4. "Crystal structure of Mandelate racemase/muconate lactonizing enzyme."
      Kim J., Toro R., Bhosle R., Al Obaidi N.F., Morisco L.L., Wasserman S.R., Sojitra S., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Stead M., Hillerich B., Love J., Seidel R.D., Imker H.J., Gerlt J.A., Almo S.C.
      Submitted (SEP-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS).

    Entry informationi

    Entry nameiA4AFX2_9ACTN
    AccessioniPrimary (citable) accession number: A4AFX2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3