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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

CA2559_05450

Organism
Croceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciCATL216432:GHTE-1108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:CA2559_05450Imported
OrganismiCroceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090)Imported
Taxonomic identifieri216432 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeCroceibacter
ProteomesiUP000002297 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi216432.CA2559_05450.

Structurei

3D structure databases

ProteinModelPortaliA3U7G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 2 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiAPHFYLT.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3U7G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVINMPRL SDTMEEGVVA KWLKQKGDKV EEGDILAEIE TDKATMEFES
60 70 80 90 100
FYEGVLLHIG VEEGETAPVD QLLAIIGEEG EDISDLLNGS SASGSKSDKE
110 120 130 140 150
DKKSSESDNE ESNDEEKTDE KEESSSDDSG IPEGVEIITM PRLSDTMEEG
160 170 180 190 200
TVATWLKQEG DTIEEGDILA EIETDKATME FESFYSGTLL KIGVAEGETA
210 220 230 240 250
KVDKLLAIIG PEGTDVSGIS GDSPKASKAE TKSSKEEKDA KADTDKEETS
260 270 280 290 300
SKSSTTSDGK RIFVSPLAKK MAEEKGIDLS EVNGSGDNGR IVKKDIENFK
310 320 330 340 350
PSATSKKDTA QAKESQTNEA PTIQPYVPAG EESFEETKNS QMRKTIAKRL
360 370 380 390 400
GESKFSAPHY YLTVEINMEH AMSSRSQINQ MPDVKVSYND MVIKAAAMAL
410 420 430 440 450
RKHPQVNSQW DGDKTKVANH IHMGVAVAVD EGLLVPVLKF ADQMSLTQIG
460 470 480 490 500
GNVKSLAGKA RNKKITPDEM SGSTFTVSNL GMFGITEFTS IINQPNSSIL
510 520 530 540 550
SIGAIVEKPV VKNGEIVVGH TMKVTMANDH RTVDGATGAQ FLQTFKTYME

NPVTMLA
Length:557
Mass (Da):60,325
Last modified:April 3, 2007 - v1
Checksum:i78C0A38C6A543D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002046 Genomic DNA. Translation: EAP88179.1.
RefSeqiWP_013186854.1. NC_014230.1.

Genome annotation databases

EnsemblBacteriaiEAP88179; EAP88179; CA2559_05450.
KEGGicat:CA2559_05450.
PATRICi38157766. VBICroAtl46233_1089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002046 Genomic DNA. Translation: EAP88179.1.
RefSeqiWP_013186854.1. NC_014230.1.

3D structure databases

ProteinModelPortaliA3U7G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216432.CA2559_05450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEAP88179; EAP88179; CA2559_05450.
KEGGicat:CA2559_05450.
PATRICi38157766. VBICroAtl46233_1089.

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiAPHFYLT.

Enzyme and pathway databases

BioCyciCATL216432:GHTE-1108-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Croceibacter atlanticus HTCC2559T."
    Oh H.M., Kang I., Ferriera S., Giovannoni S.J., Cho J.C.
    J. Bacteriol. 192:4796-4797(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-628 / HTCC2559 / KCTC 12090Imported.

Entry informationi

Entry nameiA3U7G2_CROAH
AccessioniPrimary (citable) accession number: A3U7G2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.