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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

CA2559_05450

Organism
Croceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
LigandPyruvateImported

Enzyme and pathway databases

BioCyciCATL216432:G1GTH-1098-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:CA2559_05450Imported
OrganismiCroceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090)Imported
Taxonomic identifieri216432 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeCroceibacter
Proteomesi
  • UP000002297 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi216432.CA2559_05450

Structurei

3D structure databases

ProteinModelPortaliA3U7G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 77Lipoyl-bindingInterPro annotationAdd BLAST76
Domaini135 – 210Lipoyl-bindingInterPro annotationAdd BLAST76
Domaini263 – 300Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
KOiK00627
OMAiTMEFESF
OrthoDBiPOG091H0NG1

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

A3U7G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVINMPRL SDTMEEGVVA KWLKQKGDKV EEGDILAEIE TDKATMEFES
60 70 80 90 100
FYEGVLLHIG VEEGETAPVD QLLAIIGEEG EDISDLLNGS SASGSKSDKE
110 120 130 140 150
DKKSSESDNE ESNDEEKTDE KEESSSDDSG IPEGVEIITM PRLSDTMEEG
160 170 180 190 200
TVATWLKQEG DTIEEGDILA EIETDKATME FESFYSGTLL KIGVAEGETA
210 220 230 240 250
KVDKLLAIIG PEGTDVSGIS GDSPKASKAE TKSSKEEKDA KADTDKEETS
260 270 280 290 300
SKSSTTSDGK RIFVSPLAKK MAEEKGIDLS EVNGSGDNGR IVKKDIENFK
310 320 330 340 350
PSATSKKDTA QAKESQTNEA PTIQPYVPAG EESFEETKNS QMRKTIAKRL
360 370 380 390 400
GESKFSAPHY YLTVEINMEH AMSSRSQINQ MPDVKVSYND MVIKAAAMAL
410 420 430 440 450
RKHPQVNSQW DGDKTKVANH IHMGVAVAVD EGLLVPVLKF ADQMSLTQIG
460 470 480 490 500
GNVKSLAGKA RNKKITPDEM SGSTFTVSNL GMFGITEFTS IINQPNSSIL
510 520 530 540 550
SIGAIVEKPV VKNGEIVVGH TMKVTMANDH RTVDGATGAQ FLQTFKTYME

NPVTMLA
Length:557
Mass (Da):60,325
Last modified:April 3, 2007 - v1
Checksum:i78C0A38C6A543D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002046 Genomic DNA Translation: EAP88179.1
RefSeqiWP_013186854.1, NC_014230.1

Genome annotation databases

EnsemblBacteriaiEAP88179; EAP88179; CA2559_05450
KEGGicat:CA2559_05450

Similar proteinsi

Entry informationi

Entry nameiA3U7G2_CROAH
AccessioniPrimary (citable) accession number: A3U7G2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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