A3THE5 (A3THE5_9MICO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protease HtpX homolog HAMAP-Rule MF_00188
EC=3.4.24.- HAMAP-Rule MF_00188

Gene names

Name:	htpX HAMAP-Rule MF_00188
ORF Names:	JNB_08789 EMBL EAQ00255.1

Organism

Janibacter sp. HTCC2649 EMBL EAQ00255.1

Taxonomic identifier

313589 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Intrasporangiaceae › Janibacter

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00188 RuleBase RU003983 SAAS SAAS001915
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00188.
Sequence similarities	Belongs to the peptidase M48B family. HAMAP-Rule MF_00188 RuleBase RU003983
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Biological process	Stress response EMBL EAQ00255.1
Cellular component	Cell membrane HAMAP-Rule MF_00188 SAAS SAAS001915 Membrane
Domain	Transmembrane Transmembrane helix HAMAP-Rule MF_00188 SAAS SAAS001915
Ligand	Metal-binding HAMAP-Rule MF_00188 SAAS SAAS001915 Zinc HAMAP-Rule MF_00188 SAAS SAAS001915 RuleBase RU003983
Molecular function	Hydrolase Metalloprotease HAMAP-Rule MF_00188 SAAS SAAS001915 RuleBase RU003983 Protease
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	12 – 32	21	Helical; By similarity HAMAP-Rule MF_00188
	Transmembrane	34 – 54	21	Helical; By similarity HAMAP-Rule MF_00188
	Transmembrane	148 – 168	21	Helical; By similarity HAMAP-Rule MF_00188
	Transmembrane	188 – 208	21	Helical; By similarity HAMAP-Rule MF_00188
Sites
	Active site	139	1	By similarity HAMAP-Rule MF_00188
	Metal binding	138	1	Zinc; catalytic By similarity HAMAP-Rule MF_00188
	Metal binding	142	1	Zinc; catalytic By similarity HAMAP-Rule MF_00188
	Metal binding	213	1	Zinc; catalytic By similarity HAMAP-Rule MF_00188

Sequences

	Sequence		Length	Mass (Da)
	A3THE5 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 7AB00F99AC8588C8	FASTA	296	31,638
	10 20 30 40 50 60 MHNHFNGAKT AGLFGLIMAL FLGLGWVAAT YFGNPSFIFI FALFGVAMTF YSFWNSDKLA 70 80 90 100 110 120 IKAMQAFPVS ETEAPAMYRI VRELSTKAGQ PMPRLYISPT EAPNAFATGR NPQNAAVCCT 130 140 150 160 170 180 QGILQLLDER ELRGVLGHEL MHVYNRDILT GSVAAAIAGV ISSVGQMLAF SSMFGGGNRD 190 200 210 220 230 240 NDNPGGAMAG LAMAFIAPIG AMVIQLAITR TREYDADEDG ATLTGDPLAL ASALAKLESG 250 260 270 280 290 VSRAPLAPTK NLVNASHMMI ANPFRSQDIS RLMSTHPPMA DRIARLQAMA TGYRPS

References

[1]	"Genome sequence of the Marine Janibacter Sp. Strain HTCC2649." Thrash J.C., Cho J.C., Bertagnolli A.D., Ferriera S., Johnson J., Vergin K.L., Giovannoni S.J. J. Bacteriol. 193:584-585(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: HTCC2649 EMBL EAQ00255.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAMN01000001 Genomic DNA. Translation: EAQ00255.1.
3D structure databases
ProteinModelPortal	A3THE5.
ModBase	Search...
Protein family/group databases
MEROPS	M48.004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EAQ00255; EAQ00255; JNB_08789.
PATRIC	27561515. VBIJanSp77695_1689.
Family and domain databases
HAMAP	MF_00188. Peptidase_M48.
InterPro	IPR022919. Pept_M48_protease_HtpX. IPR001915. Peptidase_M48. [Graphical view]
Pfam	PF01435. Peptidase_M48. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A3THE5_9MICO

Accession

Primary (citable) accession number: A3THE5

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)