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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Roseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotationSAAS annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
ORF Names:ISM_07135Imported
OrganismiRoseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM)Imported
Taxonomic identifieri89187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseovarius
Proteomesi
  • UP000005954 Componenti: Unassembled WGS sequence

Subcellular locationi

A3SL19:
  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi89187.ISM_07135.

Structurei

3D structure databases

ProteinModelPortaliA3SL19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 109tRNA_anti_2InterPro annotationAdd BLAST93
Domaini133 – 358Exonuc_VII_LInterPro annotationAdd BLAST226
Domaini348 – 492Exonuc_VII_LInterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the XseA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiView protein in InterPro
IPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
PANTHERiPTHR30008. PTHR30008. 1 hit.
PfamiView protein in Pfam
PF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

A3SL19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLIDDPLP GQNMPEYTVS EISGEVKRTL EGNFGRVRVR GEVGRVFKAR
60 70 80 90 100
SGHLYYDVKD DKNVLACTTW KGQVAGLSVE PEEGLEVVVT GRLTAFGAQS
110 120 130 140 150
KYNLNVDEVA VAGQGALMAL LEKRRKALAA EGLFDEGRKR PIPYLPEIIG
160 170 180 190 200
VVTSPSGAVI RDILHRLRDR FPRKVLIWPV AVQGQSSAAE VARAIAGFNA
210 220 230 240 250
LTPGGALPRP DLIIVARGGG SIEDLWGFNE EIVVRAAAAS EIPLISAVGH
260 270 280 290 300
ETDTTLIDFA SDKRAPTPTA AAELAVPVRL DLLAWLDGQS ARLSHALSSG
310 320 330 340 350
VERRGQRLRD LGRALPRVDS LLDGPRQRLD VWGERLPAAL IRSVQMRRVR
360 370 380 390 400
LSDAAGALRP AALRGKLRDQ GQRLTQTGER LGHALGARTE RGRERYDAMS
410 420 430 440 450
ARFGRVEPHE ALQRRREDLT RLSDRFGQVG ARQIKDWRDR LDALDRLRET
460 470 480 490 500
LSYKATLERG YAVVRGDGDL IKSAAAAGRA QNLEIEFADG VHKVGQPGAP
510
APKKPAKPQT PPGDQGSLF
Length:519
Mass (Da):56,536
Last modified:April 3, 2007 - v1
Checksum:i3AA311209DE10D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AALY01000001 Genomic DNA. Translation: EAP78050.1.
RefSeqiWP_009813451.1. NZ_CH724156.1.

Genome annotation databases

EnsemblBacteriaiEAP78050; EAP78050; ISM_07135.

Similar proteinsi

Entry informationi

Entry nameiA3SL19_ROSNI
AccessioniPrimary (citable) accession number: A3SL19
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 25, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported