A3RL32 (A3RL32_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Interferon gamma PIRNR PIRNR001936
Short name=IFN-gamma PIRNR PIRNR001936

Gene names

Name:

Ifng MGI 107656

Organism

Mus musculus (Mouse) EMBL ABN80441.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons By similarity. PIRNR PIRNR001936
Subunit structure	Homodimer By similarity. PIRNR PIRNR001936
Subcellular location	Secreted By similarity PIRNR PIRNR001936.
Sequence similarities	Belongs to the type II (or gamma) interferon family. PIRNR PIRNR001936

Ontologies

Keywords
Biological process	Antiviral defense PIRNR PIRNR001936 Growth regulation PIRNR PIRNR001936
Cellular component	Secreted PIRNR PIRNR001936
Molecular function	Cytokine PIRNR PIRNR001936
Gene Ontology (GO)
Biological_process	CD8-positive, alpha-beta T cell differentiation involved in immune response Inferred from direct assay PubMed 17277142. Source: MGI adaptive immune response Inferred from direct assay PubMed 17277142. Source: MGI antigen processing and presentation Inferred from direct assay PubMed 15356141. Source: MGI cellular response to interleukin-18 Inferred from direct assay PubMed 19666510. Source: MGI cellular response to lipopolysaccharide Inferred from direct assay PubMed 18791161. Source: MGI defense response to bacterium Inferred from direct assay PubMed 15240719. Source: MGI defense response to protozoan Inferred from mutant phenotype PubMed 9348310. Source: MGI defense response to virus Inferred from direct assay PubMed 20064371. Source: MGI endoplasmic reticulum unfolded protein response Inferred from direct assay PubMed 15911877. Source: MGI humoral immune response Inferred from direct assay PubMed 17277142. Source: MGI negative regulation of growth of symbiont in host Inferred from mutant phenotype PubMed 9348310. Source: MGI negative regulation of myelination Inferred from direct assay PubMed 15911877. Source: MGI neutrophil apoptotic process Inferred from mutant phenotype PubMed 12925700. Source: MGI neutrophil chemotaxis Inferred from direct assay PubMed 12925700. Source: MGI positive regulation of MHC class II biosynthetic process Inferred from direct assay PubMed 11027433. Source: MGI positive regulation of T cell proliferation Inferred from direct assay PubMed 16280321. Source: MGI positive regulation of chemokine biosynthetic process Inferred from direct assay PubMed 12925700. Source: MGI positive regulation of interleukin-1 beta secretion Inferred from mutant phenotype PubMed 12925700. Source: MGI positive regulation of interleukin-12 biosynthetic process Inferred from direct assay PubMed 14568984. Source: MGI positive regulation of interleukin-12 production Inferred from direct assay PubMed 9348310. Source: MGI positive regulation of interleukin-6 biosynthetic process Inferred from direct assay PubMed 12925700. Source: MGI positive regulation of isotype switching to IgG isotypes Inferred from direct assay PubMed 12882831. Source: MGI positive regulation of nitric oxide biosynthetic process Inferred from direct assay PubMed 11168643. Source: MGI positive regulation of peptidyl-serine phosphorylation of STAT protein Inferred from sequence orthology PubMed 16280321. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 18025219. Source: MGI positive regulation of tyrosine phosphorylation of Stat1 protein Inferred from sequence orthology PubMed 16280321. Source: MGI
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 16177108PubMed 17658279PubMed 19838199PubMed 20399120PubMed 20956546PubMed 21217760PubMed 21606376PubMed 21613615PubMed 21709260. Source: MGI extracellular space Inferred from direct assay PubMed 10072077PubMed 11057672PubMed 11728336PubMed 11894098PubMed 15220916PubMed 15240714PubMed 16275384PubMed 16769892PubMed 17082577PubMed 17277142PubMed 18997793PubMed 19139201PubMed 20706986PubMed 21460847PubMed 9348310. Source: MGI
Molecular_function	cytokine activity Inferred from direct assay PubMed 11027433PubMed 11911824PubMed 12925700PubMed 15240719. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3RL32 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 5820FBAECB4219D5	FASTA	155	17,935
	10 20 30 40 50 60 MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF LDIWRNWQKD 70 80 90 100 110 120 GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT TFFSNSKARK DAFMSIAKFE 130 140 150 VNNPQVQRQA FNELIRVVHQ LLPESSLRKR KRSRC

References

[1]	"Cloning and expression of a 468 bp cDNA fragment encoding 17.9 kDa gamma interferon of Mus musculus in eukaryotic bicistronic vector." Kadam M., Goswami P.P., Chakravarthy S., Tiwari V., Prasad N.S., Chandra Sekar S. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Swiss Albino EMBL ABN80441.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF423643 mRNA. Translation: ABN80441.1.
IPI	IPI00136892.
UniGene	Mm.240327.
3D structure databases
ProteinModelPortal	A3RL32.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:107656. Ifng.
Phylogenomic databases
HOVERGEN	HBG056912.
InParanoid	A3RL32.
Gene expression databases
Genevestigator	A3RL32.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR002069. Interferon_gamma. [Graphical view]
PANTHER	PTHR11419. PTHR11419. 1 hit.
Pfam	PF00714. IFN-gamma. 1 hit. [Graphical view]
PIRSF	PIRSF001936. IFN-gamma. 1 hit.
ProDom	PD002435. Interferon_gamma. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	35544732.
SOURCE	Search...

Entry information

Entry name

A3RL32_MOUSE

Accession

Primary (citable) accession number: A3RL32

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)