A3RL32 (A3RL32_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Interferon gamma PIRNR PIRNR001936
Short name=IFN-gamma PIRNR PIRNR001936

Gene names

Name:

Ifng MGI 107656

Organism

Mus musculus (Mouse) EMBL ABN80441.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	155 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons By similarity. PIRNR PIRNR001936
Subunit structure	Homodimer By similarity. PIRNR PIRNR001936
Subcellular location	Secreted By similarity PIRNR PIRNR001936.
Sequence similarities	Belongs to the type II (or gamma) interferon family. PIRNR PIRNR001936

Ontologies

Keywords
Biological process	Antiviral defense PIRNR PIRNR001936 Growth regulation PIRNR PIRNR001936
Cellular component	Secreted PIRNR PIRNR001936
Molecular function	Cytokine PIRNR PIRNR001936
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: InterPro regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW response to virus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interferon-gamma receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3RL32 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 5820FBAECB4219D5	FASTA	155	17,935
	10 20 30 40 50 60 MNATHCILAL QLFLMAVSGC YCHGTVIESL ESLNNYFNSS GIDVEEKSLF LDIWRNWQKD 70 80 90 100 110 120 GDMKILQSQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT TFFSNSKARK DAFMSIAKFE 130 140 150 VNNPQVQRQA FNELIRVVHQ LLPESSLRKR KRSRC

References

[1]

"Cloning and expression of a 468 bp cDNA fragment encoding 17.9 kDa gamma interferon of Mus musculus in eukaryotic bicistronic vector." Kadam M., Goswami P.P., Chakravarthy S., Tiwari V., Prasad N.S., Chandra Sekar S. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Swiss Albino EMBL ABN80441.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF423643 mRNA. Translation: ABN80441.1.
IPI	IPI00136892.
UniGene	Mm.240327.
3D structure databases
ProteinModelPortal	A3RL32.
ModBase	Search...
Protein-protein interaction databases
STRING	A3RL32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	roNOG17793.
HOVERGEN	HBG056912.
InParanoid	A3RL32.
Gene expression databases
Genevestigator	A3RL32.
Family and domain databases
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR002069. Interferon_gamma. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHER	PTHR11419. IFN-gamma. 1 hit.
Pfam	PF00714. IFN-gamma. 1 hit. [Graphical view]
PIRSF	PIRSF001936. IFN-gamma. 1 hit.
ProDom	PD002435. Interferon_gamma. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3RL32_MOUSE

Accession

Primary (citable) accession number: A3RL32

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	September 21, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)