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Protein

Forkhead box protein O1-A

Gene

foxo1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi134 – 22895Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-198693. AKT phosphorylates targets in the nucleus.
R-DRE-211163. AKT-mediated inactivation of FOXO1A.
R-DRE-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein O1-A
Gene namesi
Name:foxo1a
Synonyms:foxo1, foxO1a.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-061013-59. foxo1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652Forkhead box protein O1-APRO_0000419246Add
BLAST

Proteomic databases

PaxDbiA3RK74.

Expressioni

Developmental stagei

Expressed in the developing eye. In 48h embryos, enriched within the periocular mesenchyme (POM), in the branchial arch region and in the developing pancreas.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087386.

Structurei

3D structure databases

ProteinModelPortaliA3RK74.
SMRiA3RK74. Positions 135-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi101 – 1044Poly-Gln
Compositional biasi113 – 12210Poly-Ala
Compositional biasi126 – 1294Poly-Ser

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00790000123003.
HOGENOMiHOG000251635.
HOVERGENiHBG057789.
InParanoidiA3RK74.
KOiK07201.
OMAiKWPGSPN.
PhylomeDBiA3RK74.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3RK74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAQNQMV EIDPDFEPLS RPRSCTWPLP RPEFPNPAAA DSNTSSPAPS
60 70 80 90 100
VKQEPSSTAD FINNLSLLEE NEDYPDQKPL MLCSEFQCQE NCIHQQQIPS
110 120 130 140 150
QQQQVPVLSS PVAAAAAAAA AAQRKSSSSR RNAWGNMSYA DLITKAIESS
160 170 180 190 200
PEKRLTLSQI YDWMVKSVPY FKDKGDSNSS AGWKNSIRHN LSLHSRFIRV
210 220 230 240 250
QNEGTGKSSW WMLNPEGGKS GKSPRRRAAS MDNNSKFAKS RGRAAKKKLA
260 270 280 290 300
LQGGPEGGAD SPGSQYGKWP GSPNSHSNDD FEAWTAFRPR TSSNASTLSG
310 320 330 340 350
RLSPFIDDEL GDSDVHMVYP GPGSGTKMTS TLPSLSEMAG SLGHSGSENV
360 370 380 390 400
MENLLDNLNL LSPKNPSTGG PGSGSNQSSP SSLMQASPGY SPYSSPGLSA
410 420 430 440 450
VSQQTQQDFR KCLYGQAGMG SMSPMPMQPL PESKPSFGPG GGTMGQFNCT
460 470 480 490 500
AGLLKELLTS DGEPGDLMPS VDTVVSQSAG GSGCMLPPYS SGRNELMGGG
510 520 530 540 550
PTHSHTLSHP HNMHGQAPPT SVALNGRSLH PLTAIGHSSV GGRLGSGKSP
560 570 580 590 600
MQMQYGGSGH LGGGLPPYCS MSSNGYGRGP GMMAHQQLQH LEKLPSDLDG
610 620 630 640 650
MPIERFECDV ESILHDTLMD GESLDFNFDP MNSQQGFVPH SVKTTTHSWV

SG
Length:652
Mass (Da):69,348
Last modified:April 3, 2007 - v1
Checksum:iCC2103BAAB1083AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF421424 mRNA. Translation: ABO10192.1.
BX649258 Genomic DNA. No translation available.
RefSeqiNP_001070725.2. NM_001077257.2.
XP_009289702.1. XM_009291427.1.
UniGeneiDr.85892.

Genome annotation databases

EnsembliENSDART00000171723; ENSDARP00000134884; ENSDARG00000099555.
GeneIDi768121.
KEGGidre:768121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF421424 mRNA. Translation: ABO10192.1.
BX649258 Genomic DNA. No translation available.
RefSeqiNP_001070725.2. NM_001077257.2.
XP_009289702.1. XM_009291427.1.
UniGeneiDr.85892.

3D structure databases

ProteinModelPortaliA3RK74.
SMRiA3RK74. Positions 135-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087386.

Proteomic databases

PaxDbiA3RK74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000171723; ENSDARP00000134884; ENSDARG00000099555.
GeneIDi768121.
KEGGidre:768121.

Organism-specific databases

CTDi768121.
ZFINiZDB-GENE-061013-59. foxo1a.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00790000123003.
HOGENOMiHOG000251635.
HOVERGENiHBG057789.
InParanoidiA3RK74.
KOiK07201.
OMAiKWPGSPN.
PhylomeDBiA3RK74.

Enzyme and pathway databases

ReactomeiR-DRE-198693. AKT phosphorylates targets in the nucleus.
R-DRE-211163. AKT-mediated inactivation of FOXO1A.
R-DRE-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

PROiA3RK74.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A."
    Berry F.B., Skarie J.M., Mirzayans F., Fortin Y., Hudson T.J., Raymond V., Link B.A., Walter M.A.
    Hum. Mol. Genet. 17:490-505(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiFX1AA_DANRE
AccessioniPrimary (citable) accession number: A3RK74
Secondary accession number(s): F1RBQ1, F8W360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: April 3, 2007
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.