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Protein
Submitted name:

ATP-dependent RNA helicase DDX1

Gene

DDX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseImported, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-dependent RNA helicase DDX1Imported
Submitted name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1, isoform CRA_dImported
Submitted name:
DEAD box polypeptide 1Imported
Submitted name:
cDNA, FLJ94573, Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 (DDX1), mRNAImported
Gene namesi
Name:DDX1Imported
ORF Names:hCG_15914Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000079785.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27199

PTM / Processingi

Proteomic databases

PRIDEiA3RJH1

Expressioni

Gene expression databases

BgeeiENSG00000079785
ExpressionAtlasiA3RJH1 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiA3RJH1, 2 interactors

Structurei

3D structure databases

SMRiA3RJH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 30Q_MOTIFInterPro annotationAdd BLAST29
Domaini33 – 94Helicase ATP-bindingInterPro annotationAdd BLAST62
Domaini70 – 247B30.2/SPRYInterPro annotationAdd BLAST178
Domaini255 – 428Helicase ATP-bindingInterPro annotationAdd BLAST174
Domaini493 – 681Helicase C-terminalInterPro annotationAdd BLAST189

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 30Q motifPROSITE-ProRule annotationAdd BLAST29

Phylogenomic databases

eggNOGiKOG0349 Eukaryota
COG0513 LUCA
HOVERGENiHBG005462
KOiK13177
OMAiTLNNVKQ
OrthoDBiEOG091G03WJ

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51192 HELICASE_ATP_BIND_1, 2 hits
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

A3RJH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFSEMGVM PEIAQAVEEM DWLLPTDIQA ESIPLILGGG DVLMAAETGS
60 70 80 90 100
GKTGAFSIPV IQIVYETLKD QQEGKKGKTT IKTGASVLNK WQMNPYDRGS
110 120 130 140 150
AFAIGSDGLC CQSREVKEWH GCRATKGLMK GKHYYEVSCH DQGLCRVGWS
160 170 180 190 200
TMQASLDLGT DKFGFGFGGT GKKSHNKQFD NYGEEFTMHD TIGCYLDIDK
210 220 230 240 250
GHVKFSKNGK DLGLAFEIPP HMKNQALFPA CVLKNAELKF NFGEEEFKFP
260 270 280 290 300
PKDGFVALSK APDGYIVKSQ HSGNAQVTQT KFLPNAPKAL IVEPSRELAE
310 320 330 340 350
QTLNNIKQFK KYIDNPKLRE LLIIGGVAAR DQLSVLENGV DIVVGTPGRL
360 370 380 390 400
DDLVSTGKLN LSQVRFLVLD EADGLLSQGY SDFINRMHNQ IPQVTSDGKR
410 420 430 440 450
LQVIVCSATL HSFDVKKLSE KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP
460 470 480 490 500
KTDRLWERLG KSHIRTDDVH AKDNTRPGAN SPEMWSEAIK ILKGEYAVRA
510 520 530 540 550
IKEHKMDQAI IFCRTKIDCD NLEQYFIQQG GGPDKKGHQF SCVCLHGDRK
560 570 580 590 600
PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV
610 620 630 640 650
HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSSRGKGCYN TRLKEDGGCT
660 670 680 690 700
IWYNEMQLLS EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGS
710 720 730 740
YKGHVDILAP TVQELAALEK EAQTSFLHLG YLPNQLFRTF
Length:740
Mass (Da):82,432
Last modified:April 3, 2007 - v1
Checksum:iC6D0179F83BD8C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF418570 mRNA Translation: ABN70940.1
EF418571 mRNA Translation: ABN70941.1
AK313933 mRNA Translation: BAG36652.1
AB593031 mRNA Translation: BAJ83985.1
AB593032 mRNA Translation: BAJ83986.1
AB593034 mRNA Translation: BAJ83988.1
CH471053 Genomic DNA Translation: EAX00897.1
RefSeqiNP_004930.1, NM_004939.2
UniGeneiHs.440599

Genome annotation databases

GeneIDi1653
KEGGihsa:1653

Similar proteinsi

Entry informationi

Entry nameiA3RJH1_HUMAN
AccessioniPrimary (citable) accession number: A3RJH1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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