Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A3RGC1

- VDR_PIG

UniProt

A3RGC1 - VDR_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Vitamin D3 receptor

Gene

VDR

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Vitamin D3By similarity
Binding sitei305 – 3051Vitamin D3By similarity
Binding sitei397 – 3971Vitamin D3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 9676Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 7920NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcitriol binding Source: Ensembl
  2. calcitriol receptor activity Source: InterPro
  3. lithocholic acid binding Source: Ensembl
  4. lithocholic acid receptor activity Source: Ensembl
  5. sequence-specific DNA binding Source: InterPro
  6. steroid hormone receptor activity Source: InterPro
  7. vitamin D response element binding Source: Ensembl
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. calcium ion transport Source: Ensembl
  2. cell morphogenesis Source: Ensembl
  3. cellular calcium ion homeostasis Source: Ensembl
  4. decidualization Source: Ensembl
  5. intestinal absorption Source: Ensembl
  6. lactation Source: Ensembl
  7. mammary gland branching involved in pregnancy Source: Ensembl
  8. negative regulation of keratinocyte proliferation Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. organ morphogenesis Source: Ensembl
  11. positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
  12. positive regulation of keratinocyte differentiation Source: Ensembl
  13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. positive regulation of vitamin D 24-hydroxylase activity Source: Ensembl
  15. regulation of calcidiol 1-monooxygenase activity Source: Ensembl
  16. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_202329. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D3 receptor
Short name:
VDR
Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene namesi
Name:VDR
Synonyms:NR1I1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 5

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Vitamin D3 receptorPRO_0000337877Add
BLAST

Interactioni

Subunit structurei

Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliA3RGC1.
SMRiA3RGC1. Positions 21-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 19195HingeAdd
BLAST
Regioni192 – 427236Ligand-bindingAdd
BLAST
Regioni227 – 23711Vitamin D3 bindingBy similarityAdd
BLAST
Regioni246 – 26419Interaction with coactivator LXXLL motifBy similarityAdd
BLAST
Regioni271 – 2788Vitamin D3 bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi168 – 22558Ser-richAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 7920NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118837.
HOVERGENiHBG108655.
InParanoidiA3RGC1.
KOiK08539.
OMAiFCQFRPP.
OrthoDBiEOG79KPF8.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3RGC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEATAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR
60 70 80 90 100
SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV
110 120 130 140 150
QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYADF
160 170 180 190 200
GQFRPPVRGD EEEGTLPSRS SSAHAPSFSG SSSSSCSDQY TSSPDTMEPA
210 220 230 240 250
SFSHLDLSEE DSDDPSVTLD LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG
260 270 280 290 300
FRDLTAEDQI VLLKSSAIEV IMLRSNQSFT MDDMSWTCGS RDYKYQVSDV
310 320 330 340 350
AKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDPT
360 370 380 390 400
LIEAIQDRLS NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ
410 420
YRCLSFQPEC SMKLTPLVLE VFGNEIS
Length:427
Mass (Da):48,128
Last modified:April 3, 2007 - v1
Checksum:i79670A39FE013858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF405627 mRNA. Translation: ABN80095.1.
RefSeqiNP_001090883.1. NM_001097414.1.
UniGeneiSsc.51953.

Genome annotation databases

EnsembliENSSSCT00000032274; ENSSSCP00000019810; ENSSSCG00000020864.
GeneIDi396628.
KEGGissc:396628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF405627 mRNA. Translation: ABN80095.1 .
RefSeqi NP_001090883.1. NM_001097414.1.
UniGenei Ssc.51953.

3D structure databases

ProteinModelPortali A3RGC1.
SMRi A3RGC1. Positions 21-423.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi A3RGC1.
ChEMBLi CHEMBL5304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000032274 ; ENSSSCP00000019810 ; ENSSSCG00000020864 .
GeneIDi 396628.
KEGGi ssc:396628.

Organism-specific databases

CTDi 7421.

Phylogenomic databases

GeneTreei ENSGT00760000118837.
HOVERGENi HBG108655.
InParanoidi A3RGC1.
KOi K08539.
OMAi FCQFRPP.
OrthoDBi EOG79KPF8.
TreeFami TF316304.

Enzyme and pathway databases

Reactomei REACT_202329. Nuclear Receptor transcription pathway.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vitamin D receptor characterization."
    Fernandez A.I., Silio L., Rodriguez C., Ovilo C.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVDR_PIG
AccessioniPrimary (citable) accession number: A3RGC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3