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A3RGC1

- VDR_PIG

UniProt

A3RGC1 - VDR_PIG

Protein

Vitamin D3 receptor

Gene

VDR

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431Vitamin D3By similarity
    Binding sitei305 – 3051Vitamin D3By similarity
    Binding sitei397 – 3971Vitamin D3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi21 – 9676Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 7920NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcitriol binding Source: Ensembl
    2. calcitriol receptor activity Source: InterPro
    3. lithocholic acid binding Source: Ensembl
    4. lithocholic acid receptor activity Source: Ensembl
    5. sequence-specific DNA binding Source: InterPro
    6. steroid hormone receptor activity Source: InterPro
    7. vitamin D response element binding Source: Ensembl
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: Ensembl
    2. cell morphogenesis Source: Ensembl
    3. cellular calcium ion homeostasis Source: Ensembl
    4. decidualization Source: Ensembl
    5. intestinal absorption Source: Ensembl
    6. lactation Source: Ensembl
    7. mammary gland branching involved in pregnancy Source: Ensembl
    8. negative regulation of keratinocyte proliferation Source: Ensembl
    9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. organ morphogenesis Source: Ensembl
    11. positive regulation of apoptotic process involved in mammary gland involution Source: Ensembl
    12. positive regulation of keratinocyte differentiation Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. positive regulation of vitamin D 24-hydroxylase activity Source: Ensembl
    15. regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    16. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_202329. Nuclear Receptor transcription pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vitamin D3 receptor
    Short name:
    VDR
    Alternative name(s):
    1,25-dihydroxyvitamin D3 receptor
    Nuclear receptor subfamily 1 group I member 1
    Gene namesi
    Name:VDR
    Synonyms:NR1I1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 5

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Vitamin D3 receptorPRO_0000337877Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA3RGC1.
    SMRiA3RGC1. Positions 21-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 19195HingeAdd
    BLAST
    Regioni192 – 427236Ligand-bindingAdd
    BLAST
    Regioni227 – 23711Vitamin D3 bindingBy similarityAdd
    BLAST
    Regioni246 – 26419Interaction with coactivator LXXLL motifBy similarityAdd
    BLAST
    Regioni271 – 2788Vitamin D3 bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi168 – 22558Ser-richAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 7920NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00720000108423.
    HOVERGENiHBG108655.
    KOiK08539.
    OMAiFCQFRPP.
    OrthoDBiEOG79KPF8.
    TreeFamiTF316304.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR000324. VitD_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00350. VITAMINDR.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3RGC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEATAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR    50
    SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV 100
    QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYADF 150
    GQFRPPVRGD EEEGTLPSRS SSAHAPSFSG SSSSSCSDQY TSSPDTMEPA 200
    SFSHLDLSEE DSDDPSVTLD LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG 250
    FRDLTAEDQI VLLKSSAIEV IMLRSNQSFT MDDMSWTCGS RDYKYQVSDV 300
    AKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDPT 350
    LIEAIQDRLS NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ 400
    YRCLSFQPEC SMKLTPLVLE VFGNEIS 427
    Length:427
    Mass (Da):48,128
    Last modified:April 3, 2007 - v1
    Checksum:i79670A39FE013858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF405627 mRNA. Translation: ABN80095.1.
    RefSeqiNP_001090883.1. NM_001097414.1.
    UniGeneiSsc.51953.

    Genome annotation databases

    EnsembliENSSSCT00000032274; ENSSSCP00000019810; ENSSSCG00000020864.
    GeneIDi396628.
    KEGGissc:396628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF405627 mRNA. Translation: ABN80095.1 .
    RefSeqi NP_001090883.1. NM_001097414.1.
    UniGenei Ssc.51953.

    3D structure databases

    ProteinModelPortali A3RGC1.
    SMRi A3RGC1. Positions 21-423.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL5304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000032274 ; ENSSSCP00000019810 ; ENSSSCG00000020864 .
    GeneIDi 396628.
    KEGGi ssc:396628.

    Organism-specific databases

    CTDi 7421.

    Phylogenomic databases

    GeneTreei ENSGT00720000108423.
    HOVERGENi HBG108655.
    KOi K08539.
    OMAi FCQFRPP.
    OrthoDBi EOG79KPF8.
    TreeFami TF316304.

    Enzyme and pathway databases

    Reactomei REACT_202329. Nuclear Receptor transcription pathway.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR000324. VitD_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00350. VITAMINDR.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vitamin D receptor characterization."
      Fernandez A.I., Silio L., Rodriguez C., Ovilo C.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiVDR_PIG
    AccessioniPrimary (citable) accession number: A3RGC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3