A3RGC1 (VDR_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vitamin D3 receptor
Short name=VDR

Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1

Gene names

Name:	VDR
Synonyms:	NR1I1

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis By similarity.
Subunit structure	Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1 By similarity.
Subcellular location	Nucleus By similarity.
Domain	Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain By similarity.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium ion transport Inferred from electronic annotation. Source: Compara cell morphogenesis Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara decidualization Inferred from electronic annotation. Source: Compara intestinal absorption Inferred from electronic annotation. Source: Compara lactation Inferred from electronic annotation. Source: Compara mammary gland branching involved in pregnancy Inferred from electronic annotation. Source: Compara negative regulation of keratinocyte proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process involved in mammary gland involution Inferred from electronic annotation. Source: Compara positive regulation of keratinocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of vitamin D 24-hydroxylase activity Inferred from electronic annotation. Source: Compara regulation of calcidiol 1-monooxygenase activity Inferred from electronic annotation. Source: Compara skeletal system development Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro vitamin D response element binding Inferred from electronic annotation. Source: Compara vitamin D3 receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Vitamin D3 receptor		PRO_0000337877
Regions
	DNA binding	21 – 96	76	Nuclear receptor
	Zinc finger	24 – 44	21	NR C4-type
	Zinc finger	60 – 79	20	NR C4-type
	Region	97 – 191	95	Hinge
	Region	192 – 427	236	Ligand-binding
	Region	227 – 237	11	Vitamin D3 binding By similarity
	Region	246 – 264	19	Interaction with coactivator LXXLL motif By similarity
	Region	271 – 278	8	Vitamin D3 binding By similarity
	Compositional bias	168 – 225	58	Ser-rich
Sites
	Binding site	143	1	Vitamin D3 By similarity
	Binding site	305	1	Vitamin D3 By similarity
	Binding site	397	1	Vitamin D3 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3RGC1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 79670A39FE013858	FASTA	427	48,128
	10 20 30 40 50 60 MEATAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC 70 80 90 100 110 120 PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL 130 140 150 160 170 180 RPKLSEEQQR IIAILLDAHH KTYDPTYADF GQFRPPVRGD EEEGTLPSRS SSAHAPSFSG 190 200 210 220 230 240 SSSSSCSDQY TSSPDTMEPA SFSHLDLSEE DSDDPSVTLD LSQLSMLPHL ADLVSYSIQK 250 260 270 280 290 300 VIGFAKMIPG FRDLTAEDQI VLLKSSAIEV IMLRSNQSFT MDDMSWTCGS RDYKYQVSDV 310 320 330 340 350 360 AKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDPT LIEAIQDRLS 370 380 390 400 410 420 NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ YRCLSFQPEC SMKLTPLVLE VFGNEIS

References

[1]	"Vitamin D receptor characterization." Fernandez A.I., Silio L., Rodriguez C., Ovilo C. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF405627 mRNA. Translation: ABN80095.1.
RefSeq	NP_001090883.1. NM_001097414.1.
UniGene	Ssc.51953.
3D structure databases
ProteinModelPortal	A3RGC1.
SMR	A3RGC1. Positions 21-423.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSSCT00000032274; ENSSSCP00000019810; ENSSSCG00000020864.
GeneID	396628.
KEGG	ssc:396628.
Organism-specific databases
CTD	7421.
Phylogenomic databases
GeneTree	ENSGT00680000099585.
HOVERGEN	HBG108655.
KO	K08539.
OMA	NESFTMD.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER. PR00350. VITAMINDR.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL5304.

Entry information

Entry name

VDR_PIG

Accession

Primary (citable) accession number: A3RGC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	April 3, 2007
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program