Reviewed, UniProtKB/Swiss-Prot A3RF36 (AL3A1_CANFA)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase, dimeric NADP-preferring
    EC=1.2.1.5
Alternative name(s):
    Aldehyde dehydrogenase family 3 member A1
      Short name=Aldehyde dehydrogenase 3
    ALDHIII

Gene names

Name:	ALDH3A1
Synonyms:	ALDH3

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes By similarity.
Catalytic activity	An aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Aldehyde dehydrogenase, dimeric NADP-preferring		PRO_0000289586
Regions
	Nucleotide binding	188 – 193	6	NAD By similarity
Sites
	Active site	210	1	By similarity
	Active site	244	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3RF36-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: E986E2EF8D8AE46A	FASTA	453	50,713
	10 20 30 40 50 60 MSKISEVVQR ARAAFNSGKT RPLQFRIQQL EALRRMIKEH EKDLAGALTA DLHKNEWNAY 70 80 90 100 110 120 YEEVVYVLEE IEYMIKKLPE WAADEPVEKT PQTQQDECYI HSEPLGVVLI IGTWNYPFTV 130 140 150 160 170 180 TIQPMVGAIA AGNAVVIKPS ELSENMANLL ATIIPQYLDR DLYPVISGGI PETTELLKER 190 200 210 220 230 240 FDHILYTGNT AVGKVIMMAA AKHLTPVTLE LGGKNPCYVD KDCDLDIACR RIAWGKFMNS 250 260 270 280 290 300 GQTCVAPDYI LCDPSIQNQI VEKLKKALKE FYGEDAKKSR DYGRIINSRH FQRVMGLMEG 310 320 330 340 350 360 QKVAYGGTGD AATRYIAPTI LIDVDTQSQV MQEEIFGPVM PIVCVRSLEE AIQFINQREK 370 380 390 400 410 420 PLALYVFSLN DKMIKKMIAE TSSGGVTAND VIVHVSVHSL PYGGVGNSGM GSYHGKKSFE 430 440 450 TFSHCRSCLV RPLLNDESLK TRYPPSLAKM TRH

References

[1]	Wistow G. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cornea.

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF382362 mRNA. Translation: ABN70935.1.
RefSeq	NP_001075889.1.
UniGene	Cfa.22321
3D structure databases
SMR	A3RF36. Positions 4-448.
ModBase	Search...
Genome annotation databases
GeneID	489526.
KEGG	cfa:489526.
Enzyme and pathway databases
BRENDA	1.2.1.5. 463.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR012394. Aldehyde_DH_NAD(P). [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF036492. ALDH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL3A1_CANFA

Accession

Primary (citable) accession number: A3RF36

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	April 3, 2007
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)