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A3QVN5

- HYAL4_CERCE

UniProt

A3QVN5 - HYAL4_CERCE

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Protein
Hyaluronidase-4
Gene
N/A
Organism
Cerastes cerastes (Horned desert viper)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix. In addition, it displays antiedematogenic activity By similarity.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Proton donor By similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-4 (EC:3.2.1.35)
Short name:
Hy-4
Alternative name(s):
Hyaluronoglucosaminidase-4
Venom spreading factor
OrganismiCerastes cerastes (Horned desert viper)
Taxonomic identifieri8697 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeCerastes

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 449426Hyaluronidase-4
PRO_0000420460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 340 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi211 ↔ 227 By similarity
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi365 ↔ 376 By similarity
Disulfide bondi370 ↔ 427 By similarity
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi429 ↔ 438 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliA3QVN5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini427 – 43812EGF-like
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

HOVERGENiHBG052053.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3QVN5-1 [UniParc]FASTAAdd to Basket

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MYHIWIKFLA AWIFLKRFNG VHVMQAKAPM YRNEPFLVFW NAPTTQCRLR    50
YKVDLDLKTF HIVSNANDSL SGSAVTIFYP NHLGVYPHID DRGHFFHGII 100
PQNESLTKHL NKSKSDINRI IPLKAFHGLG VIDWENWRPQ WDRNWGSKNV 150
YRNRSIQFAR DLHPELSEDK IRRLAKKEYE KAAKSFMRDT LLLAEEMRPD 200
GYWGYYLYPD CQNYDYKTKG DQYTGKCPEI EMSRNDQLLW LWRDSTALFP 250
NVYLEIILRS SDNALKFVHH RLKEAMRIAS MAREDYALPV FAYARPFYAY 300
TFEPLTQEDL VTTVGETAAM GAAGIVFWGS VQYASTVDSC QKVKKYMNGP 350
LGRYIVNVTT AAKICSRVLC RKNGRCVRKH SDSNAFLHLF PESFRIMVYA 400
NATEKKVIVK GKLELENLIY LRENFMCQCY QGWKGLYCEE YSIKDIRKI 449
Length:449
Mass (Da):52,622
Last modified:April 3, 2007 - v1
Checksum:iE96697FCA6918F60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ840252 mRNA. Translation: ABI33940.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ840252 mRNA. Translation: ABI33940.1 .

3D structure databases

ProteinModelPortali A3QVN5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG052053.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of cDNAs encoding viper venom hyaluronidases: cross-generic sequence conservation of full-length and unusually short variant transcripts."
    Harrison R.A., Ibison F., Wilbraham D., Wagstaff S.C.
    Gene 392:22-33(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiHYAL4_CERCE
AccessioniPrimary (citable) accession number: A3QVN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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