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A3QVN3 (HYAL1_CERCE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase-1

Short name=Hy-1
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase-1
Venom spreading factor
OrganismCerastes cerastes (Horned desert viper)
Taxonomic identifier8697 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeCerastes

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Snake venom endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. In venom, it is not toxic by itself, but increases the diffusion of other venom proteins by degrading the extracellular matrix. In addition, it displays antiedematogenic activity By similarity.

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Signal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 449426Hyaluronidase-1
PRO_0000420458

Regions

Domain427 – 43812EGF-like

Sites

Active site1351Proton donor By similarity

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 340 By similarity
Disulfide bond211 ↔ 227 By similarity
Disulfide bond365 ↔ 376 By similarity
Disulfide bond370 ↔ 427 By similarity
Disulfide bond429 ↔ 438 By similarity

Sequences

Sequence LengthMass (Da)Tools
A3QVN3 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: F26697FCBD918460

FASTA44952,654
        10         20         30         40         50         60 
MYHIWIKFLA AWIFLKRFNG VHVMQAKAPM YRNEPFLVFW NAPTTQCRLR YKVDLDLKTF 

        70         80         90        100        110        120 
HIVSNANDSL SGSAVTIFYP NHLGVYPHID DRGHFFHGII PQNESLTKHL NKSKSDINRI 

       130        140        150        160        170        180 
IPLKAFHGLG VIDWENWRPQ WDRNWGSKNV YRNRSIQFAR DLHPELSEDK IRRLAKKEYE 

       190        200        210        220        230        240 
KAAKSFMRDT LLLAEEMRPD GYWGYYLYPD CQNYDYKTKG DQYTGKCPEI EMSRNDQLLW 

       250        260        270        280        290        300 
LWRDSTALFP NVYLEIILRS SDNALKFVHH RLKEAMRIAS MAREDYALPV FAYARPFYAY 

       310        320        330        340        350        360 
TFEPLTQEDL VTTVGETAAM GAAGIVFWGS MQYASTVDSC QKVKKYMNGP LGRYIVNVTT 

       370        380        390        400        410        420 
AAKICSRVLC RKNGRCVRKH SDSNAFLHLF PESFRIMVYA NATEKKVIVK GKLELENLIY 

       430        440 
LRENFMCQCY QGWKGLYCEE YSIKDIRKI 

« Hide

References

[1]"Identification of cDNAs encoding viper venom hyaluronidases: cross-generic sequence conservation of full-length and unusually short variant transcripts."
Harrison R.A., Ibison F., Wilbraham D., Wagstaff S.C.
Gene 392:22-33(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ840250 mRNA. Translation: ABI33938.1.

3D structure databases

ProteinModelPortalA3QVN3.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG052053.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFPIRSF038193. Hyaluronidase. 1 hit.
PRINTSPR00846. GLHYDRLASE56.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHYAL1_CERCE
AccessionPrimary (citable) accession number: A3QVN3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries