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A3QPB9 (IL21_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Interleukin-21
Short name=IL-21
Gene names
Name:Il21
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 146129Interleukin-21
PRO_0000313746

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 115 Potential
Disulfide bond71 ↔ 118 Potential

Sequences

Sequence LengthMass (Da)Tools
A3QPB9 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 48F80086BC2557B9

FASTA14617,065
        10         20         30         40         50         60 
MERTLVCLIL IFLGTVAHKS SPQRPDHLLI RLRHLMDIVE QLKIYENDLD PELLTAPQDV 

        70         80         90        100        110        120 
KGQCEHEAFA CFQKAKLKPS NTGNNKTFIN DLLAQLRRRL PAKRTGNKQR HMAKCPSCDL 

       130        140 
YEKKTPKEFL ERLKWLLQKM IHQHLS

« Hide

References

[1]Wu P.W.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ387062 mRNA. Translation: ABD52001.1.
IPIIPI00368229.
RefSeqNP_001102413.1. NM_001108943.2.
UniGeneRn.214949.

3D structure databases

ProteinModelPortalA3QPB9.
SMRA3QPB9. Positions 23-146.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000023348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000023348; ENSRNOP00000023348; ENSRNOG00000017376.
GeneID365769.
KEGGrno:365769.
UCSCRGD:1307384. rat.

Organism-specific databases

CTD59067.
RGD1307384. Il21.

Phylogenomic databases

eggNOGNOG40525.
GeneTreeENSGT00390000010494.
HOGENOMHOG000113039.
HOVERGENHBG052106.
InParanoidA3QPB9.
KOK05434.
OMADVKRHCE.
OrthoDBEOG4DJJXM.

Gene expression databases

GenevestigatorA3QPB9.

Family and domain databases

InterProIPR003443. Interleukin_15-like.
[Graphical view]
PfamPF02372. IL15. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio688003.

Entry information

Entry nameIL21_RAT
AccessionPrimary (citable) accession number: A3QPB9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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