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A3QPB9

- IL21_RAT

UniProt

A3QPB9 - IL21_RAT

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Protein

Interleukin-21

Gene
Il21
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. immune response Source: InterPro
  3. positive regulation of B cell proliferation Source: Ensembl
  4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  5. positive regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of interleukin-17 production Source: Ensembl
  7. positive regulation of natural killer cell cytokine production Source: Ensembl
  8. positive regulation of natural killer cell differentiation Source: Ensembl
  9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  10. positive regulation of T cell proliferation Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:Il21
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1307384. Il21.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000313746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115 Reviewed prediction
Disulfide bondi71 ↔ 118 Reviewed prediction
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA3QPB9.

Expressioni

Gene expression databases

GenevestigatoriA3QPB9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023348.

Structurei

3D structure databases

ProteinModelPortaliA3QPB9.
SMRiA3QPB9. Positions 23-146.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
GeneTreeiENSGT00390000010494.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiA3QPB9.
KOiK05434.
OMAiEQSAFSC.
OrthoDBiEOG7M98JN.
PhylomeDBiA3QPB9.
TreeFamiTF336380.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A3QPB9-1 [UniParc]FASTAAdd to Basket

« Hide

MERTLVCLIL IFLGTVAHKS SPQRPDHLLI RLRHLMDIVE QLKIYENDLD    50
PELLTAPQDV KGQCEHEAFA CFQKAKLKPS NTGNNKTFIN DLLAQLRRRL 100
PAKRTGNKQR HMAKCPSCDL YEKKTPKEFL ERLKWLLQKM IHQHLS 146
Length:146
Mass (Da):17,065
Last modified:April 3, 2007 - v1
Checksum:i48F80086BC2557B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ387062 mRNA. Translation: ABD52001.1.
RefSeqiNP_001102413.1. NM_001108943.2.
UniGeneiRn.214949.

Genome annotation databases

EnsembliENSRNOT00000023348; ENSRNOP00000023348; ENSRNOG00000017376.
GeneIDi365769.
KEGGirno:365769.
UCSCiRGD:1307384. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ387062 mRNA. Translation: ABD52001.1 .
RefSeqi NP_001102413.1. NM_001108943.2.
UniGenei Rn.214949.

3D structure databases

ProteinModelPortali A3QPB9.
SMRi A3QPB9. Positions 23-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000023348.

Proteomic databases

PRIDEi A3QPB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023348 ; ENSRNOP00000023348 ; ENSRNOG00000017376 .
GeneIDi 365769.
KEGGi rno:365769.
UCSCi RGD:1307384. rat.

Organism-specific databases

CTDi 59067.
RGDi 1307384. Il21.

Phylogenomic databases

eggNOGi NOG40525.
GeneTreei ENSGT00390000010494.
HOGENOMi HOG000113039.
HOVERGENi HBG052106.
InParanoidi A3QPB9.
KOi K05434.
OMAi EQSAFSC.
OrthoDBi EOG7M98JN.
PhylomeDBi A3QPB9.
TreeFami TF336380.

Miscellaneous databases

NextBioi 688003.
PROi A3QPB9.

Gene expression databases

Genevestigatori A3QPB9.

Family and domain databases

InterProi IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view ]
PANTHERi PTHR14356. PTHR14356. 1 hit.
Pfami PF02372. IL15. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Wu P.W.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiIL21_RAT
AccessioniPrimary (citable) accession number: A3QPB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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