A3QMC8 (GMPPB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase beta
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta

Gene names

Name:	tag-335
ORF Names:	C42C1.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro determination of adult lifespan Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase oogenesis Inferred from mutant phenotype. Source: WormBase receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Mannose-1-phosphate guanyltransferase beta		PRO_0000307170

Sequences

	Sequence		Length	Mass (Da)
	A3QMC8 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 95D21189EB6984F2	FASTA	365	40,099
	10 20 30 40 50 60 MKALILVGGY GTRLRPLTLT QPKPLVEFAN KPMMLHQMEA LAEVGVDTVV LAVSYRAEQL 70 80 90 100 110 120 EQEMTVHADR LGVKLIFSLE EEPLGTAGPL ALARKHLEGD APFFVLNSDV ICDFPFKQMV 130 140 150 160 170 180 EFHKNHGKEG TIAVTKVEEP SKYGVVVFDQ DKGKIDDFVE KPQEYVGNKI NAGLYIFSSK 190 200 210 220 230 240 ILDRIPLKPT SIEKEIFPEM AFSGNLYAFV LPGFWMDVGQ PKDFLKGMSL FLNHCHTTKS 250 260 270 280 290 300 DKLETGSNIH PTATIRGNVM VDPSATVGEN CVIGPDVVIG PRVKIEGGVR ILHSTILSDS 310 320 330 340 350 360 SIGNYSWVSG SIVGRKCHIG SWVRIENICV IGDDVVVKDE LYLNGASVLP HKSIAVNVPS KDIIM

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU457741 Genomic DNA. Translation: CAM36360.1.
RefSeq	NP_502333.2. NM_069932.4.
UniGene	Cel.13354.
3D structure databases
ProteinModelPortal	A3QMC8.
SMR	A3QMC8. Positions 1-364.
ModBase	Search...
Protein-protein interaction databases
STRING	A3QMC8.
Proteomic databases
PRIDE	A3QMC8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C42C1.5; C42C1.5; C42C1.5.
GeneID	183400.
KEGG	cel:C42C1.5.
NMPDR	fig|6239.3.peg.15445.
UCSC	C42C1.5. c. elegans.
Organism-specific databases
CTD	183400.
WormBase	C42C1.5; CE40443; WBGene00016583; tag-335.
Phylogenomic databases
eggNOG	meNOG04303.
GeneTree	EMGT00050000014275.
HOGENOM	HBG688195.
InParanoid	A3QMC8.
OMA	HETAVIG.
PhylomeDB	A3QMC8.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	921004.

Entry information

Entry name

GMPPB_CAEEL

Accession

Primary (citable) accession number: A3QMC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project