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Protein

Mannose-1-phosphate guanyltransferase beta

Gene

tag-335

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase beta (tag-335)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase beta (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta
Gene namesi
Name:tag-335
ORF Names:C42C1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC42C1.5; CE40443; WBGene00016583; tag-335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003071701 – 365Mannose-1-phosphate guanyltransferase betaAdd BLAST365

Proteomic databases

EPDiA3QMC8.
PaxDbiA3QMC8.
PeptideAtlasiA3QMC8.
PRIDEiA3QMC8.

Expressioni

Gene expression databases

BgeeiWBGene00016583.

Interactioni

Protein-protein interaction databases

STRINGi6239.C42C1.5.

Structurei

3D structure databases

ProteinModelPortaliA3QMC8.
SMRiA3QMC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1322. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
InParanoidiA3QMC8.
KOiK00966.
OMAiYICEIRE.
OrthoDBiEOG091G0AYY.
PhylomeDBiA3QMC8.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3QMC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALILVGGY GTRLRPLTLT QPKPLVEFAN KPMMLHQMEA LAEVGVDTVV
60 70 80 90 100
LAVSYRAEQL EQEMTVHADR LGVKLIFSLE EEPLGTAGPL ALARKHLEGD
110 120 130 140 150
APFFVLNSDV ICDFPFKQMV EFHKNHGKEG TIAVTKVEEP SKYGVVVFDQ
160 170 180 190 200
DKGKIDDFVE KPQEYVGNKI NAGLYIFSSK ILDRIPLKPT SIEKEIFPEM
210 220 230 240 250
AFSGNLYAFV LPGFWMDVGQ PKDFLKGMSL FLNHCHTTKS DKLETGSNIH
260 270 280 290 300
PTATIRGNVM VDPSATVGEN CVIGPDVVIG PRVKIEGGVR ILHSTILSDS
310 320 330 340 350
SIGNYSWVSG SIVGRKCHIG SWVRIENICV IGDDVVVKDE LYLNGASVLP
360
HKSIAVNVPS KDIIM
Length:365
Mass (Da):40,099
Last modified:April 3, 2007 - v1
Checksum:i95D21189EB6984F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU457741 Genomic DNA. Translation: CAM36360.1.
RefSeqiNP_502333.2. NM_069932.5.
UniGeneiCel.13354.

Genome annotation databases

EnsemblMetazoaiC42C1.5; C42C1.5; WBGene00016583.
GeneIDi183400.
KEGGicel:CELE_C42C1.5.
UCSCiC42C1.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU457741 Genomic DNA. Translation: CAM36360.1.
RefSeqiNP_502333.2. NM_069932.5.
UniGeneiCel.13354.

3D structure databases

ProteinModelPortaliA3QMC8.
SMRiA3QMC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C42C1.5.

Proteomic databases

EPDiA3QMC8.
PaxDbiA3QMC8.
PeptideAtlasiA3QMC8.
PRIDEiA3QMC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC42C1.5; C42C1.5; WBGene00016583.
GeneIDi183400.
KEGGicel:CELE_C42C1.5.
UCSCiC42C1.5. c. elegans.

Organism-specific databases

CTDi183400.
WormBaseiC42C1.5; CE40443; WBGene00016583; tag-335.

Phylogenomic databases

eggNOGiKOG1322. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
InParanoidiA3QMC8.
KOiK00966.
OMAiYICEIRE.
OrthoDBiEOG091G0AYY.
PhylomeDBiA3QMC8.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00930.

Miscellaneous databases

PROiA3QMC8.

Gene expression databases

BgeeiWBGene00016583.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMPPB_CAEEL
AccessioniPrimary (citable) accession number: A3QMC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.