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Protein

Acetoacetyl-CoA synthetase

Gene

aacs

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Activates acetoacetate to acetoacetyl-CoA.By similarity

Catalytic activityi

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-734-MONOMER.
ReactomeiR-DRE-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA synthetase (EC:6.2.1.16)
Gene namesi
Name:aacs
ORF Names:si:dkey-215k6.2, zgc:56105
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-040426-903. aacs.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Acetoacetyl-CoA synthetasePRO_0000315789Add
BLAST

Proteomic databases

PaxDbiA3QK15.
PeptideAtlasiA3QK15.
PRIDEiA3QK15.

Expressioni

Gene expression databases

BgeeiENSDARG00000012468.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002180.

Structurei

3D structure databases

ProteinModelPortaliA3QK15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00820000127056.
HOGENOMiHOG000229992.
HOVERGENiHBG059947.
InParanoidiA3QK15.
KOiK01907.
OMAiVWDFCGI.
OrthoDBiEOG091G05B0.
PhylomeDBiA3QK15.
TreeFamiTF354241.

Family and domain databases

InterProiIPR005914. Acac_CoA_synth.
IPR032387. ACAS_N.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A3QK15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKDTEAKSE EIMESKVLWY PDSKRNTQTD RFRTLVNREF GLNLANYNDL
60 70 80 90 100
YQWSVDSYPE FWAQVWKFCG ITCSKMYEEV VDVSKRISDV PEWFKGSRLN
110 120 130 140 150
YAENLLKHKD QDKVALYAAS EAKEEIVKVT FGELRRDVAL FAAAMRKMGI
160 170 180 190 200
KIGDRVVGYL PNGVHAVEAM LAAASIGAIW SSTSPDFGVN GVLDRISQIQ
210 220 230 240 250
PKLIFSVAAV VYNGKQHDHM EKLQNVVKGL PDLKKVVVIP YVRSRQETDL
260 270 280 290 300
SKIPNSVFLE DFLATGKEGD QDPQLEFEQL PFSHPLFIMY SSGTTGAPKC
310 320 330 340 350
MVHSAGGTLI QHLKEHILHG NMTFNDVIIY YTTTGWMMWN WLISSLAVGA
360 370 380 390 400
SVVLYDGSPL VPSANVLWDL VDRLGITIFG TGAKWLAVLE ERDQKPASTH
410 420 430 440 450
SLQTLHTLLS TGSPLKPQSY EYVYSCIKNN VLLGSISGGT DIISCFMGQN
460 470 480 490 500
MTVPVYRGEI QARNLGMAVE SWSCEGKPVW GESGELVCLK PIPCQPTHFW
510 520 530 540 550
NDENGSKYHK AYFSTFPGVW AHGDYCKINP KTGGVVMLGR SDGTLNPNGV
560 570 580 590 600
RFGSSEIYNI VEAFDEVSDS LCVPQYNSDG EERVILFLKM GPNKSFSQEL
610 620 630 640 650
VGKIRGAIRV ALSARHVPAL ILETKDIPYT ISGKKVEVAV KQVIAGKEVT
660 670
QRGAFSNPDS LDLYKNLPEL QNF
Length:673
Mass (Da):74,967
Last modified:April 3, 2007 - v1
Checksum:i71CACCD9B2049782
GO
Isoform 2 (identifier: A3QK15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-359: Missing.

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):73,637
Checksum:iE648C2C4A3F391D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641V → I in AAH50501 (Ref. 2) Curated
Sequence conflicti431 – 4311V → M in AAH50501 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei346 – 35914Missing in isoform 2. 1 PublicationVSP_030703Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759959 Genomic DNA. Translation: CAM56650.1.
BC050501 mRNA. Translation: AAH50501.1.
RefSeqiNP_957303.1. NM_201009.1.
XP_005165133.1. XM_005165076.2. [A3QK15-1]
UniGeneiDr.25204.

Genome annotation databases

EnsembliENSDART00000010101; ENSDARP00000002180; ENSDARG00000012468. [A3QK15-1]
GeneIDi393984.
KEGGidre:393984.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR759959 Genomic DNA. Translation: CAM56650.1.
BC050501 mRNA. Translation: AAH50501.1.
RefSeqiNP_957303.1. NM_201009.1.
XP_005165133.1. XM_005165076.2. [A3QK15-1]
UniGeneiDr.25204.

3D structure databases

ProteinModelPortaliA3QK15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002180.

Proteomic databases

PaxDbiA3QK15.
PeptideAtlasiA3QK15.
PRIDEiA3QK15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000010101; ENSDARP00000002180; ENSDARG00000012468. [A3QK15-1]
GeneIDi393984.
KEGGidre:393984.

Organism-specific databases

CTDi65985.
ZFINiZDB-GENE-040426-903. aacs.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00820000127056.
HOGENOMiHOG000229992.
HOVERGENiHBG059947.
InParanoidiA3QK15.
KOiK01907.
OMAiVWDFCGI.
OrthoDBiEOG091G05B0.
PhylomeDBiA3QK15.
TreeFamiTF354241.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-734-MONOMER.
ReactomeiR-DRE-77111. Synthesis of Ketone Bodies.

Miscellaneous databases

PROiA3QK15.

Gene expression databases

BgeeiENSDARG00000012468.

Family and domain databases

InterProiIPR005914. Acac_CoA_synth.
IPR032387. ACAS_N.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01217. ac_ac_CoA_syn. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAACS_DANRE
AccessioniPrimary (citable) accession number: A3QK15
Secondary accession number(s): Q7ZU87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.