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Protein

AarF domain-containing protein kinase 4

Gene

adck4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

May play a role in CoQ10 (coq10a and/or coq10b) biosynthesis.By similarity

GO - Molecular functioni

GO - Biological processi

  • glomerular basement membrane development Source: ZFIN
  • glomerular visceral epithelial cell development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AarF domain-containing protein kinase 4 (EC:2.7.11.-)
Gene namesi
Name:adck4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-060503-803. adck4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei189 – 20517HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown of the protein causes nephrosis phenotype of periorbital edema and total body edema in 54% of embryos at 120 hpf. The glomerular structures are altered, with podocyte foot process effacement and disorganization, rarefaction of slit membranes, and disorganization of the glomerular basement membranes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624AarF domain-containing protein kinase 4PRO_0000425572Add
BLAST

Proteomic databases

PaxDbiA3QJU3.

Interactioni

Subunit structurei

Homodimer; homodimerizes via its transmembrane region.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013965.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 517233Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
KOiK08869.
OMAiPCGGSWA.
OrthoDBiEOG7X9G6H.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.

Sequencei

Sequence statusi: Complete.

A3QJU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSEVLQVL RGAGKVGAAF TSTQGEQLRL MACNSTFGAG MKAAAEAVEG
60 70 80 90 100
VMGTVMGGGD MTSKTDEFAG IEKWEEMDLD EAAKWSVASE MPPDFSSKDG
110 120 130 140 150
RGETSETPVG AATGTIKGAG WPAQNTRFLH VSASQHHFRF VHDSIVARLS
160 170 180 190 200
PEDIQRAREA KQNIARPVRQ KLNERAKERK VPATRISRLA NFGGLAVGLG
210 220 230 240 250
IGAIAEVAKQ SFGGKRSEVG ALLDSPLLSE ANAERIVNTL CKVRGAALKI
260 270 280 290 300
GQMLSIQDNS FINPQLQKIF ERVRQSADFM PAWQMHKVLE EELGSGWREK
310 320 330 340 350
LSSIEEKPFA AASIGQVHHG VLPGGKEIAM KIQYPGVAES IHSDINNLMS
360 370 380 390 400
VLKMSVVLPD GLFADSSLEV LQRELAWECD YEREAKCAKR FRNLLKGDPV
410 420 430 440 450
FVVPEVFDEL SARRVITMEL VNGVPLDRCV DLDQETRNEI CFNILQLCLR
460 470 480 490 500
ELFEFRFMQT DPNWSNFFYN SEQNKIFLLD FGACRDYPEL FTDHYIEVVH
510 520 530 540 550
AASVGDRATV LKKSKDLKFL TGFEAKAFED AHVEAVMILG EAFASAEAFD
560 570 580 590 600
FGTQSTTQRI QSLIPVMLRH RLTPPPEESY SLHRKMAGSF LICSKLKARF
610 620
SCRNMFLDVY NAYKRQQQER RSQV
Length:624
Mass (Da):69,460
Last modified:November 13, 2013 - v2
Checksum:i4E42F359888C155F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR318657 Genomic DNA. No translation available.
RefSeqiXP_001336310.1. XM_001336274.6.

Genome annotation databases

EnsembliENSDART00000172195; ENSDARP00000132291; ENSDARG00000101130.
GeneIDi799071.
KEGGidre:799071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR318657 Genomic DNA. No translation available.
RefSeqiXP_001336310.1. XM_001336274.6.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000013965.

Proteomic databases

PaxDbiA3QJU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000172195; ENSDARP00000132291; ENSDARG00000101130.
GeneIDi799071.
KEGGidre:799071.

Organism-specific databases

CTDi79934.
ZFINiZDB-GENE-060503-803. adck4.

Phylogenomic databases

eggNOGiKOG1234. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074739.
HOGENOMiHOG000201140.
HOVERGENiHBG061318.
KOiK08869.
OMAiPCGGSWA.
OrthoDBiEOG7X9G6H.

Miscellaneous databases

PROiA3QJU3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiADCK4_DANRE
AccessioniPrimary (citable) accession number: A3QJU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: November 13, 2013
Last modified: November 11, 2015
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.