A3QJE5 (A3QJE5_SHELP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE HAMAP MF_00222
Ordered Locus Names:	Shew_3727

Organism

Shewanella loihica (strain ATCC BAA-1088 / PV-4) [Complete proteome] [HAMAP] EMBL ABO25593.1

Taxonomic identifier

323850 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ABO25593.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	156 – 160	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	95	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	A3QJE5 [UniParc]. Last modified April 17, 2007. Version 1. Checksum: 10D246DC2AD4087C	FASTA	304	32,202
	10 20 30 40 50 60 MLAPFASPKK LSRLSAIESN RDHIPMTQQV QDRYAVFGHP IGHSKSPAIH QAFAKSTGES 70 80 90 100 110 120 LQYEAILAPL DGFAESLRAF FEHGGKGANV TLPFKEQAYA LCDCLGDEAK LAGAVNTLTR 130 140 150 160 170 180 LADGRIKGDN TDGLGLVADL ERHLGSLCGK SVLLIGAGGA ARGAILPLLN AGIDSLTIHN 190 200 210 220 230 240 RTHSKAEQLA EAFKAYGQVK ASTLDELTHS FDIVINSTSA SLSGELPSLP KAIIAAHSVC 250 260 270 280 290 300 YDMMYGRELT AFNHWALDQG ASQTIDGLGM LVGQAAKSFA IWRGVEPAVE PVLAKLRSEL ASQA

References

[1]

"Complete sequence of Shewanella loihica PV-4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Serres G., Fredrickson J., Tiedje J., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1088 / PV-4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000606 Genomic DNA. Translation: ABO25593.1.
RefSeq	YP_001095852.1. NC_009092.1.
3D structure databases
ProteinModelPortal	A3QJE5.
SMR	A3QJE5. Positions 32-301.
ModBase	Search...
Protein-protein interaction databases
STRING	A3QJE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4921021.
GenomeReviews	Gene locus Shew_3727 in contig CP000606_GR.
KEGG	slo:Shew_3727.
NMPDR	fig|323850.3.peg.1662.
PATRIC	23519409. VBISheLoi132094_3728.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
PhylomeDB	A3QJE5.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	SLOI323850:SHEW_3727-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3QJE5_SHELP

Accession

Primary (citable) accession number: A3QJE5

Entry history

Integrated into UniProtKB/TrEMBL:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)