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A3QJ17

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UniProt

A3QJ17 - MEND_SHELP

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Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

Cofactori

Magnesium or manganese.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-3716-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00164.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
Short name:
SEPHCHC synthaseUniRule annotation
Alternative name(s):
Menaquinone biosynthesis protein MenDUniRule annotation
Gene namesi
Name:menDUniRule annotation
Ordered Locus Names:Shew_3599
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5675672-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_0000341833Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi323850.Shew_3599.

Structurei

3D structure databases

ProteinModelPortaliA3QJ17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1165.
HOGENOMiHOG000218360.
KOiK02551.
OMAiTQVIEVR.
OrthoDBiEOG6NWBQW.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
HAMAPiMF_01659. MenD.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004983. MenD. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00173. menD. 1 hit.

Sequencei

Sequence statusi: Complete.

A3QJ17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQIEKTAELN LLWGSLILEE LARLEVQHVC MAPGSRSTPL TLAAAKQTKL
60 70 80 90 100
KQHLHFDERG LGFLALGLAK ASRAPVAIIT TSGTAVANLY PAIVEAWLTQ
110 120 130 140 150
VPLIVLSGDR PPELLGCGAN QAIVQPAIFA DYAKQVNLPT PDMAIPPQAL
160 170 180 190 200
LTLLDESVAN AKGPIHVNCM YREPLYPGSM SADFTHYLSP LGNWQHSALP
210 220 230 240 250
YNQFADAQLV SAPTSDALAR FVHGKGVIIA GTLAPEQQPE QLIELAQKLG
260 270 280 290 300
WPLLTDAQSQ LRQHGAAIGN IDQLLLQPKA KALLQEADTV LVFGGRLLSK
310 320 330 340 350
RLISYLSEQK WKRYWQVLPQ QTRLDPSHSA KQVWISPLAA FAQLPWPRSS
360 370 380 390 400
EANWALQLIE ANEQLATLFQ QQIDDAEFGE AQVVRTIAGR GEQQLFIGNS
410 420 430 440 450
LPVRLYDMYA PITPIAPRVF TNRGASGIDG LLATACGIAA HKASSTTLVI
460 470 480 490 500
GDLSQLHDLN SLALAAKQQG TLVIVILNND GGNIFNLLPV PDEKLRSGYY
510 520 530 540 550
RLAHGLEFGY GAAMFGLPYN RVEDIVSFNE AYDDALAYPG ASVIEVCVAQ
560
DQASEQIARL AAWIKQS
Length:567
Mass (Da):61,598
Last modified:April 17, 2007 - v1
Checksum:iA875ADE0A0FA446A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO25465.1.
RefSeqiYP_001095724.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO25465; ABO25465; Shew_3599.
GeneIDi4922504.
KEGGislo:Shew_3599.
PATRICi23519149. VBISheLoi132094_3602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO25465.1 .
RefSeqi YP_001095724.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QJ17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_3599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO25465 ; ABO25465 ; Shew_3599 .
GeneIDi 4922504.
KEGGi slo:Shew_3599.
PATRICi 23519149. VBISheLoi132094_3602.

Phylogenomic databases

eggNOGi COG1165.
HOGENOMi HOG000218360.
KOi K02551.
OMAi TQVIEVR.
OrthoDBi EOG6NWBQW.

Enzyme and pathway databases

UniPathwayi UPA00079 .
UPA01057 ; UER00164 .
BioCyci SLOI323850:GHQJ-3716-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
HAMAPi MF_01659. MenD.
InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
[Graphical view ]
Pfami PF02775. TPP_enzyme_C. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004983. MenD. 1 hit.
SUPFAMi SSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00173. menD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiMEND_SHELP
AccessioniPrimary (citable) accession number: A3QJ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3