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Protein

Thiopurine S-methyltransferase

Gene

tpm

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10S-adenosyl-L-methionineUniRule annotation1
Binding sitei45S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei66S-adenosyl-L-methionineUniRule annotation1
Binding sitei123S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSLOI323850:G1G8D-3427-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)
Alternative name(s):
Thiopurine methyltransferaseUniRule annotation
Gene namesi
Name:tpmUniRule annotation
Ordered Locus Names:Shew_3261
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000472211 – 218Thiopurine S-methyltransferaseAdd BLAST218

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_3261

Structurei

3D structure databases

ProteinModelPortaliA3QI29
SMRiA3QI29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FQ6 Bacteria
ENOG4111GNF LUCA
HOGENOMiHOG000276919
KOiK00569
OMAiMKWFADR
OrthoDBiPOG091H046Q

Family and domain databases

HAMAPiMF_00812 Thiopur_methtran, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR022474 Thiopur_S-MeTfrase_Se/Te_detox
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT
PANTHERiPTHR10259 PTHR10259, 1 hit
PTHR10259:SF16 PTHR10259:SF16, 1 hit
PfamiView protein in Pfam
PF05724 TPMT, 1 hit
PIRSFiPIRSF023956 Thiopurine_S-methyltransferase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR03840 TMPT_Se_Te, 1 hit
PROSITEiView protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

Sequencei

Sequence statusi: Complete.

A3QI29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSFWHDKW ASQQIGFHLD EVNALLIDYW PQLELAAGSQ VFVPLCGKTL
60 70 80 90 100
DLCYLAEQGL EVIGCELNQS AVEQFFSDNE LPVERQSSGE HECYRTEQVS
110 120 130 140 150
IYQGDLFRLP KEPLEAVSGF YDRAALIAWP PEMRQQYVEC LAGLLPPKSI
160 170 180 190 200
GLLITLDYPQ EALNGPPFAV SDAWIQEHMS PYFEIECLST QDVLAENPRF
210
VKKQVPWLTE SVYRLVRR
Length:218
Mass (Da):24,955
Last modified:April 17, 2007 - v1
Checksum:i33062B37EBB87910
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA Translation: ABO25127.1
RefSeqiWP_011867057.1, NC_009092.1

Genome annotation databases

EnsemblBacteriaiABO25127; ABO25127; Shew_3261
KEGGislo:Shew_3261

Similar proteinsi

Entry informationi

Entry nameiTPMT_SHELP
AccessioniPrimary (citable) accession number: A3QI29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health