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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSLOI323850:G1G8D-3218-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Shew_3062
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456101 – 962Glycine dehydrogenase (decarboxylating)Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei709N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA3QHI0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi323850.Shew_3062

Structurei

3D structure databases

ProteinModelPortaliA3QHI0
SMRiA3QHI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A3QHI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFIRRHI GPDSADQQEM LNFVGAESLE DLTQQIVPES
60 70 80 90 100
IRLGRDLAVG SACGEAEGLA SIRKYADKNK VFKSYIGMGY YGTIVPSVIQ
110 120 130 140 150
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQLSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFEIV
210 220 230 240 250
VGPASEAVNY ELFGALFQYT NHYGQITDFT ELFAALQEKK AVVTVAADIM
260 270 280 290 300
SLVSLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DQHKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
FHGPQGLKII ADRIHRLADI FAAGLKAKGV ELVNNTWFDT VSFKVADSAA
410 420 430 440 450
AQARAIAGEV NLRIDSDGIL GVAMAETTTR EDVAQLFDIV LGEGHGLDVA
460 470 480 490 500
AIDADIIANG SNSIPAELVR QDAILEHPTF NRYHSETEMM RYIKRLENKD
510 520 530 540 550
LALNHSMISL GSCTMKLNAA TEMMPVSWPE FGNMHPFCPQ DQAQGYAELI
560 570 580 590 600
EELSNWLVDI TGYDAMCMQP NSGASGEYAG LLAIKKYHES RGEGHRNVCL
610 620 630 640 650
IPQSAHGTNP ASAQLAGMKI VVTACDKQGN VDMEDLKAKA AEVAENLSCI
660 670 680 690 700
MVTYPSTHGV YEETISEICE VIHQHGGQVY LDGANMNAQV GLTSPGSIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHAV VKHGRESDNN
760 770 780 790 800
GAVSAAPYGS ASILPITWMY IKLLGYQGLR QSTQMALLNA NYVMKKLSAH
810 820 830 840 850
YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKAELD RFIEAMVAIR GEIAKVEAGE WPADNNPLHN
910 920 930 940 950
APHTMADIMD SEFDSRPYSR ETAVFPTAAV KANKFWPTVN RIDDVYGDRN
960
LMCSCAPIDD YK
Length:962
Mass (Da):104,745
Last modified:April 17, 2007 - v1
Checksum:i89C34F58A2602DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA Translation: ABO24928.1
RefSeqiWP_011866858.1, NC_009092.1

Genome annotation databases

EnsemblBacteriaiABO24928; ABO24928; Shew_3062
KEGGislo:Shew_3062

Similar proteinsi

Entry informationi

Entry nameiGCSP_SHELP
AccessioniPrimary (citable) accession number: A3QHI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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