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A3QHI0

- GCSP_SHELP

UniProt

A3QHI0 - GCSP_SHELP

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-3167-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Shew_3062
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000045610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi323850.Shew_3062.

Structurei

3D structure databases

ProteinModelPortaliA3QHI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A3QHI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFIRRHI GPDSADQQEM LNFVGAESLE DLTQQIVPES
60 70 80 90 100
IRLGRDLAVG SACGEAEGLA SIRKYADKNK VFKSYIGMGY YGTIVPSVIQ
110 120 130 140 150
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQLSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFEIV
210 220 230 240 250
VGPASEAVNY ELFGALFQYT NHYGQITDFT ELFAALQEKK AVVTVAADIM
260 270 280 290 300
SLVSLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DQHKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
FHGPQGLKII ADRIHRLADI FAAGLKAKGV ELVNNTWFDT VSFKVADSAA
410 420 430 440 450
AQARAIAGEV NLRIDSDGIL GVAMAETTTR EDVAQLFDIV LGEGHGLDVA
460 470 480 490 500
AIDADIIANG SNSIPAELVR QDAILEHPTF NRYHSETEMM RYIKRLENKD
510 520 530 540 550
LALNHSMISL GSCTMKLNAA TEMMPVSWPE FGNMHPFCPQ DQAQGYAELI
560 570 580 590 600
EELSNWLVDI TGYDAMCMQP NSGASGEYAG LLAIKKYHES RGEGHRNVCL
610 620 630 640 650
IPQSAHGTNP ASAQLAGMKI VVTACDKQGN VDMEDLKAKA AEVAENLSCI
660 670 680 690 700
MVTYPSTHGV YEETISEICE VIHQHGGQVY LDGANMNAQV GLTSPGSIGA
710 720 730 740 750
DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHAV VKHGRESDNN
760 770 780 790 800
GAVSAAPYGS ASILPITWMY IKLLGYQGLR QSTQMALLNA NYVMKKLSAH
810 820 830 840 850
YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF
860 870 880 890 900
PVAGTLMIEP TESESKAELD RFIEAMVAIR GEIAKVEAGE WPADNNPLHN
910 920 930 940 950
APHTMADIMD SEFDSRPYSR ETAVFPTAAV KANKFWPTVN RIDDVYGDRN
960
LMCSCAPIDD YK
Length:962
Mass (Da):104,745
Last modified:April 17, 2007 - v1
Checksum:i89C34F58A2602DB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24928.1.
RefSeqiYP_001095187.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO24928; ABO24928; Shew_3062.
GeneIDi4922662.
KEGGislo:Shew_3062.
PATRICi23518043. VBISheLoi132094_3061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24928.1 .
RefSeqi YP_001095187.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QHI0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_3062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO24928 ; ABO24928 ; Shew_3062 .
GeneIDi 4922662.
KEGGi slo:Shew_3062.
PATRICi 23518043. VBISheLoi132094_3061.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SLOI323850:GHQJ-3167-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiGCSP_SHELP
AccessioniPrimary (citable) accession number: A3QHI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3