Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A3QHI0

- GCSP_SHELP

UniProt

A3QHI0 - GCSP_SHELP

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSLOI323850:GHQJ-3167-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Shew_3062
    OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
    Taxonomic identifieri323850 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001558: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Glycine dehydrogenase (decarboxylating)PRO_1000045610Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi323850.Shew_3062.

    Structurei

    3D structure databases

    ProteinModelPortaliA3QHI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3QHI0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTETLTQLE QHELFIRRHI GPDSADQQEM LNFVGAESLE DLTQQIVPES    50
    IRLGRDLAVG SACGEAEGLA SIRKYADKNK VFKSYIGMGY YGTIVPSVIQ 100
    RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQLSMDLTG LDLASASLLD 150
    EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFEIV 200
    VGPASEAVNY ELFGALFQYT NHYGQITDFT ELFAALQEKK AVVTVAADIM 250
    SLVSLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DQHKRSLPGR 300
    IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
    FHGPQGLKII ADRIHRLADI FAAGLKAKGV ELVNNTWFDT VSFKVADSAA 400
    AQARAIAGEV NLRIDSDGIL GVAMAETTTR EDVAQLFDIV LGEGHGLDVA 450
    AIDADIIANG SNSIPAELVR QDAILEHPTF NRYHSETEMM RYIKRLENKD 500
    LALNHSMISL GSCTMKLNAA TEMMPVSWPE FGNMHPFCPQ DQAQGYAELI 550
    EELSNWLVDI TGYDAMCMQP NSGASGEYAG LLAIKKYHES RGEGHRNVCL 600
    IPQSAHGTNP ASAQLAGMKI VVTACDKQGN VDMEDLKAKA AEVAENLSCI 650
    MVTYPSTHGV YEETISEICE VIHQHGGQVY LDGANMNAQV GLTSPGSIGA 700
    DVSHLNLHKT FAIPHGGGGP GMGPIGVKAH LAPFVAGHAV VKHGRESDNN 750
    GAVSAAPYGS ASILPITWMY IKLLGYQGLR QSTQMALLNA NYVMKKLSAH 800
    YPVLYTGRND RVAHECIIDL RPLKEASGVT EMDIAKRLND YGFHAPTMSF 850
    PVAGTLMIEP TESESKAELD RFIEAMVAIR GEIAKVEAGE WPADNNPLHN 900
    APHTMADIMD SEFDSRPYSR ETAVFPTAAV KANKFWPTVN RIDDVYGDRN 950
    LMCSCAPIDD YK 962
    Length:962
    Mass (Da):104,745
    Last modified:April 17, 2007 - v1
    Checksum:i89C34F58A2602DB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO24928.1.
    RefSeqiYP_001095187.1. NC_009092.1.

    Genome annotation databases

    EnsemblBacteriaiABO24928; ABO24928; Shew_3062.
    GeneIDi4922662.
    KEGGislo:Shew_3062.
    PATRICi23518043. VBISheLoi132094_3061.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO24928.1 .
    RefSeqi YP_001095187.1. NC_009092.1.

    3D structure databases

    ProteinModelPortali A3QHI0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323850.Shew_3062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO24928 ; ABO24928 ; Shew_3062 .
    GeneIDi 4922662.
    KEGGi slo:Shew_3062.
    PATRICi 23518043. VBISheLoi132094_3061.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SLOI323850:GHQJ-3167-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1088 / PV-4.

    Entry informationi

    Entry nameiGCSP_SHELP
    AccessioniPrimary (citable) accession number: A3QHI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3