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A3QH47

- SYL_SHELP

UniProt

A3QH47 - SYL_SHELP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSLOI323850:GHQJ-3029-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Shew_2929
    OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
    Taxonomic identifieri323850 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001558: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_1000009424Add
    BLAST

    Proteomic databases

    PRIDEiA3QH47.

    Interactioni

    Protein-protein interaction databases

    STRINGi323850.Shew_2929.

    Structurei

    3D structure databases

    ProteinModelPortaliA3QH47.
    SMRiA3QH47. Positions 228-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3QH47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEQYLPSEI EAKVQQHWQD TKTFEVTEDE SKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA INNKTAPAPW 100
    TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTASVNWCP NDETVLANEQ VQDGCCWRCD TQVVQKEIPQ WFIKITDYAE 200
    ELLNDIDQLD EWPEQVKTMQ RNWIGRSEGI EMTFQVEGSD QSFDIYTTRP 250
    DTVMGVTYVA IAAGHPLAQQ AAENNPVLAE FIEECKNADT TEAAMAAMEK 300
    KGVDTGLKAI HPLTGKLVPI WAANFVLMNY GTGAVMSVPG HDQRDYEFAT 350
    KYGLPIVGVI KPADGELDIS EEAYTEKGIL FNSGDSFPEL DGLDFQAAFD 400
    AIDAKLSSEG KGKRQVNYRL RDWGVSRQRY WGAPIPMVTL ADGTVMPTPE 450
    DQLPVILPED VVMDGIQSPI KADKEWAKTQ VNGQEAFRET DTFDTFMESS 500
    WYYARYCSPK ADQMLDPAKA NYWLPVDQYI GGIEHACMHL LYFRFFHKLL 550
    RDIGLVNSDE PAKRLLTQGM VLADAFYYTD DKGARVWVSP NDAKVTETDD 600
    KGRIVKAVDS QGHELVYTGM SKMSKSKNNG IDPQEMVDKY GADTVRLFMM 650
    FASPPELTLE WQESSVEGAH RFIKRLWKLA HDHVSQGPTV ALNVASLDSA 700
    QKELRRELHK TIAKVGDDIE RRQMFNTAIA SVMELMNRLQ KAPMESEQDR 750
    ALMQEALCAV VRLLYPIIPH TSFELWQALG HEETIENVLW PVVDESALVE 800
    DSKLIIVQVN GKLRAKVTVA ADADKDTVEA AGMAEEGVIK HTEGKTVRKV 850
    IYVPGKLLNI VAN 863
    Length:863
    Mass (Da):97,736
    Last modified:April 17, 2007 - v1
    Checksum:i8CD8A85373777D84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO24795.1.
    RefSeqiYP_001095054.1. NC_009092.1.

    Genome annotation databases

    EnsemblBacteriaiABO24795; ABO24795; Shew_2929.
    GeneIDi4922131.
    KEGGislo:Shew_2929.
    PATRICi23517769. VBISheLoi132094_2929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO24795.1 .
    RefSeqi YP_001095054.1. NC_009092.1.

    3D structure databases

    ProteinModelPortali A3QH47.
    SMRi A3QH47. Positions 228-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323850.Shew_2929.

    Proteomic databases

    PRIDEi A3QH47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO24795 ; ABO24795 ; Shew_2929 .
    GeneIDi 4922131.
    KEGGi slo:Shew_2929.
    PATRICi 23517769. VBISheLoi132094_2929.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SLOI323850:GHQJ-3029-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1088 / PV-4.

    Entry informationi

    Entry nameiSYL_SHELP
    AccessioniPrimary (citable) accession number: A3QH47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3