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A3QG90

- LPXB_SHELP

UniProt

A3QG90 - LPXB_SHELP

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Shew_2622
Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-2711-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Shew_2622
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotationPRO_1000049416Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_2622.

Structurei

3D structure databases

ProteinModelPortaliA3QG90.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A3QG90-1 [UniParc]FASTAAdd to Basket

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MNQSNQKVFA MVAGELSGDI LGAGLIKALK QQYPDARFVG IGGPQMDALG    50
FESLFSFEEL AVMGLVEVLS RLPRLLKVRK TLIDELTALK PDCFIGIDAP 100
DFNIGLELKL KAQGIKTVHY VSPSVWAWRP KRIFKIAKAT NMVLSLLPFE 150
KAFYDKHNVP CTFVGHTLAD DIPLESDKLS ARETLGLDPH AEYLAILPGS 200
RGGELKQLAE PFVQAAVKLR QRYPDLKFVT PLVNAKRRAQ FELALKTHAP 250
DLDIHLVEGQ SRTVMAAADA ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
RIAKGMMQIS HYSLPNLLAG REIIPELIQA DCTPDKIVDA VSNQLDGDHK 350
PLMESFMTLH QQLRCDASAR AAQAVIELVE TK 382
Length:382
Mass (Da):42,104
Last modified:April 17, 2007 - v1
Checksum:i190F25E7C5211997
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24488.1.
RefSeqiYP_001094747.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO24488; ABO24488; Shew_2622.
GeneIDi4920721.
KEGGislo:Shew_2622.
PATRICi23517133. VBISheLoi132094_2621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24488.1 .
RefSeqi YP_001094747.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QG90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_2622.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO24488 ; ABO24488 ; Shew_2622 .
GeneIDi 4920721.
KEGGi slo:Shew_2622.
PATRICi 23517133. VBISheLoi132094_2621.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SLOI323850:GHQJ-2711-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiLPXB_SHELP
AccessioniPrimary (citable) accession number: A3QG90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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