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A3QG90

- LPXB_SHELP

UniProt

A3QG90 - LPXB_SHELP

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-2711-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Shew_2622
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthasePRO_1000049416Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_2622.

Structurei

3D structure databases

ProteinModelPortaliA3QG90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A3QG90-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQSNQKVFA MVAGELSGDI LGAGLIKALK QQYPDARFVG IGGPQMDALG
60 70 80 90 100
FESLFSFEEL AVMGLVEVLS RLPRLLKVRK TLIDELTALK PDCFIGIDAP
110 120 130 140 150
DFNIGLELKL KAQGIKTVHY VSPSVWAWRP KRIFKIAKAT NMVLSLLPFE
160 170 180 190 200
KAFYDKHNVP CTFVGHTLAD DIPLESDKLS ARETLGLDPH AEYLAILPGS
210 220 230 240 250
RGGELKQLAE PFVQAAVKLR QRYPDLKFVT PLVNAKRRAQ FELALKTHAP
260 270 280 290 300
DLDIHLVEGQ SRTVMAAADA ILLASGTATL EAMLVKRPMV VAYRVSPITY
310 320 330 340 350
RIAKGMMQIS HYSLPNLLAG REIIPELIQA DCTPDKIVDA VSNQLDGDHK
360 370 380
PLMESFMTLH QQLRCDASAR AAQAVIELVE TK
Length:382
Mass (Da):42,104
Last modified:April 17, 2007 - v1
Checksum:i190F25E7C5211997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA. Translation: ABO24488.1.
RefSeqiYP_001094747.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO24488; ABO24488; Shew_2622.
GeneIDi4920721.
KEGGislo:Shew_2622.
PATRICi23517133. VBISheLoi132094_2621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA. Translation: ABO24488.1 .
RefSeqi YP_001094747.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QG90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_2622.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO24488 ; ABO24488 ; Shew_2622 .
GeneIDi 4920721.
KEGGi slo:Shew_2622.
PATRICi 23517133. VBISheLoi132094_2621.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SLOI323850:GHQJ-2711-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiLPXB_SHELP
AccessioniPrimary (citable) accession number: A3QG90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3