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A3QFP3

- FADJ_SHELP

UniProt

A3QFP3 - FADJ_SHELP

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Protein

Fatty acid oxidation complex subunit alpha

Gene

fadJ

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.UniRule annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei116 – 1161Important for catalytic activityUniRule annotation
Sitei138 – 1381Important for catalytic activityUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-HAMAP
  2. 3-hydroxybutyryl-CoA epimerase activity Source: UniProtKB-HAMAP
  3. enoyl-CoA hydratase activity Source: UniProtKB-HAMAP
  4. NAD binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid degradation, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-2510-MONOMER.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alphaUniRule annotation
Including the following 2 domains:
Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimeraseUniRule annotation (EC:4.2.1.17UniRule annotation, EC:5.1.2.3UniRule annotation)
3-hydroxyacyl-CoA dehydrogenaseUniRule annotation (EC:1.1.1.35UniRule annotation)
Gene namesi
Name:fadJUniRule annotation
Ordered Locus Names:Shew_2425
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Fatty acid oxidation complex subunit alphaPRO_0000323528Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Protein-protein interaction databases

STRINGi323850.Shew_2425.

Structurei

3D structure databases

ProteinModelPortaliA3QFP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 188188Enoyl-CoA hydrataseUniRule annotationAdd
BLAST
Regioni308 – 7063993-hydroxyacyl-CoA dehydrogenaseUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000261346.
KOiK01782.
OMAiPFRYMDT.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01617. FadJ.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR02440. FadJ. 1 hit.

Sequencei

Sequence statusi: Complete.

A3QFP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKSFTLNRL DNGIAVLTMD VPGETMNTLR AEFGPEICEM LAEIKADAGI
60 70 80 90 100
RGVVIISGKK DSFVAGADIS MLDACATAED ARELSKQGHE VFFALESLSI
110 120 130 140 150
PVVAAINGAC LGGGLELALA CHQRVCTDSN KTMLGLPEVQ LGLLPGGGGT
160 170 180 190 200
QRLPRLVGIA KSLDMMLTGK QLRAKQALKM GLVDDVVPES ILLQTAIEMA
210 220 230 240 250
LAGARPAKKP KLSTVEKLLE GTPVGRNIIF EQALKQVNKK TQGNYPAPEK
260 270 280 290 300
IIDCVRQGVT KGIVKGLEVE AQHFGDLVVS NESEALRSIF FATTEMKKES
310 320 330 340 350
GAGDVSPKAV NKVMVLGGGL MGGGIASVTT TKAKIPVRVK DISEIGLSNA
360 370 380 390 400
LAYAYKLLAK GVKRRHMTPA VRDNLMALMT TTTEYKGIKD ADMVVEAVFE
410 420 430 440 450
DLNLKHQMVK DVERECGEHT IFASNTSSLP IKQIAEAAER PENVIGLHYF
460 470 480 490 500
SPVEKMPLVE VIAHDKTSPQ TIATTVAFAR KQGKTPIVVK DGAGFYVNRI
510 520 530 540 550
LALYMNEAAN LLLEGQSVDH LDKALVKFGF PVGPMTLLDE VGIDVGAKIS
560 570 580 590 600
PILEKELGER FKAPAAFDKL LADDRKGRKN GKGFYQYGAK SKKKLVDESV
610 620 630 640 650
YGVLGLTPGA DGEPIALAER CVVQMLNEAV RCLEEGIIAS PRDGDIGAIF
660 670 680 690 700
GIGFPPFLGG PFRYMDSLGA KHLVETLKRY QDQFGDRFAP CDRLVEMAES

GSKFYE
Length:706
Mass (Da):75,979
Last modified:April 17, 2007 - v1
Checksum:iACA8E59084E5B1E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24291.1.
RefSeqiYP_001094550.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO24291; ABO24291; Shew_2425.
GeneIDi4921646.
KEGGislo:Shew_2425.
PATRICi23516735. VBISheLoi132094_2425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24291.1 .
RefSeqi YP_001094550.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QFP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_2425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO24291 ; ABO24291 ; Shew_2425 .
GeneIDi 4921646.
KEGGi slo:Shew_2425.
PATRICi 23516735. VBISheLoi132094_2425.

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000261346.
KOi K01782.
OMAi PFRYMDT.
OrthoDBi EOG6M9F0M.

Enzyme and pathway databases

UniPathwayi UPA00659 .
BioCyci SLOI323850:GHQJ-2510-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPi MF_01617. FadJ.
InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR02440. FadJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiFADJ_SHELP
AccessioniPrimary (citable) accession number: A3QFP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3