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A3QF15

- HIS1_SHELP

UniProt

A3QF15 - HIS1_SHELP

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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-2277-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:Shew_2197
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299ATP phosphoribosyltransferasePRO_1000004503Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_2197.

Structurei

3D structure databases

ProteinModelPortaliA3QF15.
SMRiA3QF15. Positions 6-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223247.
KOiK00765.
OMAiTRMQGVI.
OrthoDBiEOG66MQT3.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3QF15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESNRLRIA IQKSGRLSKE SQKLLKSCGI KFNVNEQRLI AHSDNMPIDL
60 70 80 90 100
LRVRDDDIPG LVMDGVVDLG IIGENVLEEE QIERQTLDKP SECIKLRQLD
110 120 130 140 150
FGACRLSLAV PTEFRYQDAS SLEGLRIATS YPNLLRRYMQ EKGISYRDCM
160 170 180 190 200
LKGSVEVAPR AGLADGICDL VSTGATLEAN GLYETEVIYR SMACIIQSTQ
210 220 230 240 250
EQSEAKQALI DKILSRVNGV VRAKESKYIL LHAPTETLDQ IVALLPGAEN
260 270 280 290
PTVLPLNDDT NRVAIHAVSS EDLFWDTMEA LTQLGASSIL VMPIEKMMG
Length:299
Mass (Da):33,110
Last modified:April 17, 2007 - v1
Checksum:i1DF6F4E7D4AB221D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24063.1.
RefSeqiYP_001094322.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO24063; ABO24063; Shew_2197.
GeneIDi4923111.
KEGGislo:Shew_2197.
PATRICi23516263. VBISheLoi132094_2194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000606 Genomic DNA. Translation: ABO24063.1 .
RefSeqi YP_001094322.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QF15.
SMRi A3QF15. Positions 6-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_2197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO24063 ; ABO24063 ; Shew_2197 .
GeneIDi 4923111.
KEGGi slo:Shew_2197.
PATRICi 23516263. VBISheLoi132094_2194.

Phylogenomic databases

eggNOGi COG0040.
HOGENOMi HOG000223247.
KOi K00765.
OMAi TRMQGVI.
OrthoDBi EOG66MQT3.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci SLOI323850:GHQJ-2277-MONOMER.

Family and domain databases

Gene3Di 3.30.70.120. 1 hit.
HAMAPi MF_00079. HisG_Long.
InterProi IPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view ]
PANTHERi PTHR21403. PTHR21403. 1 hit.
Pfami PF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54913. SSF54913. 1 hit.
TIGRFAMsi TIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiHIS1_SHELP
AccessioniPrimary (citable) accession number: A3QF15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3