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A3QDY0

- RLMKL_SHELP

UniProt

A3QDY0 - RLMKL_SHELP

Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
    S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

    GO - Molecular functioni

    1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: UniProtKB-HAMAP
    3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSLOI323850:GHQJ-1872-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
    Including the following 2 domains:
    23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
    23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
    Gene namesi
    Name:rlmLUniRule annotation
    Ordered Locus Names:Shew_1812
    OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
    Taxonomic identifieri323850 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001558: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711Ribosomal RNA large subunit methyltransferase K/LPRO_0000366826Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi323850.Shew_1812.

    Structurei

    3D structure databases

    ProteinModelPortaliA3QDY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 154112THUMPUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
    Contains 1 THUMP domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0116.
    HOGENOMiHOG000218371.
    KOiK12297.
    OMAiNKRGFKM.
    OrthoDBiEOG6HJ238.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    HAMAPiMF_01858. 23SrRNA_methyltr_KL.
    InterProiIPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view]
    PfamiPF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTiSM00981. THUMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3QDY0-1 [UniParc]FASTAAdd to Basket

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    MLNFFAAAPR GYEYALSLEL AEFGAAEIKE SVAGVYFSAP LNLAYRITLW    50
    SRLASRIILV IYKGPCENPE QLYNAAYCID WQTHFSNKSS FSIDFHGVGG 100
    FIKNSQFGAL KIKDAVVDRF RDDGCPRPDV ARVDADFKID AHYRRGQITL 150
    GINFSGPALH QRGYRSTTGE APLKENLAAN MLVRSGWQQS PKDLLDPFCG 200
    SGTILIEAAM MACDIAPALQ RRRFGFEHWL RHQEADWQEL LAEAKARASI 250
    GTKRCEIKFY GSDIDSRLVA LAKRNAQNAG VAELIELSVS NALNVTPPVE 300
    QGYLITNPPY GERLGNVTSL LQLYYQLGDK LKAEFGGWQV AVLNSDIELL 350
    SALKLKADKQ MKMYNGALEC AFNLYTLHAN STRRLDPSQV LSQGGEVSEV 400
    ATAFSNRIKK NHKQLSKWAQ REGIDSYRLY DADIPEYNVA VDIYLDHVVI 450
    QEYSAPKSIP EAVTKRRLTD VLLVLPQAIG VDPDKIILKT RERQKGTNQY 500
    QKLDATKLEL VTTEYGAKFK LNLKDYLDTG LFLDHRLTRK LVGEKSKGRD 550
    VLNLFAYTGS ASVHAALGGA KSVTTVDMSN TYLNWAQDNF ELNGLKGKQY 600
    QFIQGDCLQW IDDCDQQYDL IFIDPPTFSN SKRMEDSFDV QRDHVKLLSA 650
    LVKLLRPGGE ILFSNNKRKF KMDSEALSAL GLSITNLDKQ TLPLDYKRNP 700
    HIHNTWLIQH A 711
    Length:711
    Mass (Da):79,892
    Last modified:April 17, 2007 - v1
    Checksum:i8BC6CAFE330CA57C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO23678.1.
    RefSeqiYP_001093937.1. NC_009092.1.

    Genome annotation databases

    EnsemblBacteriaiABO23678; ABO23678; Shew_1812.
    GeneIDi4921704.
    KEGGislo:Shew_1812.
    PATRICi23515453. VBISheLoi132094_1809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000606 Genomic DNA. Translation: ABO23678.1 .
    RefSeqi YP_001093937.1. NC_009092.1.

    3D structure databases

    ProteinModelPortali A3QDY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 323850.Shew_1812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO23678 ; ABO23678 ; Shew_1812 .
    GeneIDi 4921704.
    KEGGi slo:Shew_1812.
    PATRICi 23515453. VBISheLoi132094_1809.

    Phylogenomic databases

    eggNOGi COG0116.
    HOGENOMi HOG000218371.
    KOi K12297.
    OMAi NKRGFKM.
    OrthoDBi EOG6HJ238.

    Enzyme and pathway databases

    BioCyci SLOI323850:GHQJ-1872-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    HAMAPi MF_01858. 23SrRNA_methyltr_KL.
    InterProi IPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view ]
    Pfami PF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTi SM00981. THUMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1088 / PV-4.

    Entry informationi

    Entry nameiRLMKL_SHELP
    AccessioniPrimary (citable) accession number: A3QDY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3