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A3QDY0

- RLMKL_SHELP

UniProt

A3QDY0 - RLMKL_SHELP

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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSLOI323850:GHQJ-1872-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
Including the following 2 domains:
23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
Gene namesi
Name:rlmLUniRule annotation
Ordered Locus Names:Shew_1812
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001558: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Ribosomal RNA large subunit methyltransferase K/LPRO_0000366826Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_1812.

Structurei

3D structure databases

ProteinModelPortaliA3QDY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 154112THUMPUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
Contains 1 THUMP domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0116.
HOGENOMiHOG000218371.
KOiK12297.
OMAiNKRGFKM.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3QDY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNFFAAAPR GYEYALSLEL AEFGAAEIKE SVAGVYFSAP LNLAYRITLW
60 70 80 90 100
SRLASRIILV IYKGPCENPE QLYNAAYCID WQTHFSNKSS FSIDFHGVGG
110 120 130 140 150
FIKNSQFGAL KIKDAVVDRF RDDGCPRPDV ARVDADFKID AHYRRGQITL
160 170 180 190 200
GINFSGPALH QRGYRSTTGE APLKENLAAN MLVRSGWQQS PKDLLDPFCG
210 220 230 240 250
SGTILIEAAM MACDIAPALQ RRRFGFEHWL RHQEADWQEL LAEAKARASI
260 270 280 290 300
GTKRCEIKFY GSDIDSRLVA LAKRNAQNAG VAELIELSVS NALNVTPPVE
310 320 330 340 350
QGYLITNPPY GERLGNVTSL LQLYYQLGDK LKAEFGGWQV AVLNSDIELL
360 370 380 390 400
SALKLKADKQ MKMYNGALEC AFNLYTLHAN STRRLDPSQV LSQGGEVSEV
410 420 430 440 450
ATAFSNRIKK NHKQLSKWAQ REGIDSYRLY DADIPEYNVA VDIYLDHVVI
460 470 480 490 500
QEYSAPKSIP EAVTKRRLTD VLLVLPQAIG VDPDKIILKT RERQKGTNQY
510 520 530 540 550
QKLDATKLEL VTTEYGAKFK LNLKDYLDTG LFLDHRLTRK LVGEKSKGRD
560 570 580 590 600
VLNLFAYTGS ASVHAALGGA KSVTTVDMSN TYLNWAQDNF ELNGLKGKQY
610 620 630 640 650
QFIQGDCLQW IDDCDQQYDL IFIDPPTFSN SKRMEDSFDV QRDHVKLLSA
660 670 680 690 700
LVKLLRPGGE ILFSNNKRKF KMDSEALSAL GLSITNLDKQ TLPLDYKRNP
710
HIHNTWLIQH A
Length:711
Mass (Da):79,892
Last modified:April 17, 2007 - v1
Checksum:i8BC6CAFE330CA57C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA. Translation: ABO23678.1.
RefSeqiYP_001093937.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO23678; ABO23678; Shew_1812.
GeneIDi4921704.
KEGGislo:Shew_1812.
PATRICi23515453. VBISheLoi132094_1809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA. Translation: ABO23678.1 .
RefSeqi YP_001093937.1. NC_009092.1.

3D structure databases

ProteinModelPortali A3QDY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 323850.Shew_1812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO23678 ; ABO23678 ; Shew_1812 .
GeneIDi 4921704.
KEGGi slo:Shew_1812.
PATRICi 23515453. VBISheLoi132094_1809.

Phylogenomic databases

eggNOGi COG0116.
HOGENOMi HOG000218371.
KOi K12297.
OMAi NKRGFKM.
OrthoDBi EOG6HJ238.

Enzyme and pathway databases

BioCyci SLOI323850:GHQJ-1872-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1088 / PV-4.

Entry informationi

Entry nameiRLMKL_SHELP
AccessioniPrimary (citable) accession number: A3QDY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3