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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
Including the following 2 domains:
23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
Gene namesi
Name:rlmLUniRule annotation
Ordered Locus Names:Shew_1812
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003668261 – 711Ribosomal RNA large subunit methyltransferase K/LAdd BLAST711

Interactioni

Protein-protein interaction databases

STRINGi323850.Shew_1812.

Structurei

3D structure databases

ProteinModelPortaliA3QDY0.
SMRiA3QDY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 154THUMPUniRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4H. Bacteria.
COG0116. LUCA.
COG1092. LUCA.
HOGENOMiHOG000218371.
KOiK12297.
OMAiMSNTYLN.
OrthoDBiPOG091H03PL.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL. 1 hit.
InterProiView protein in InterPro
IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
PfamiView protein in Pfam
PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiView protein in SMART
SM00981. THUMP. 1 hit.
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiView protein in PROSITE
PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.

Sequencei

Sequence statusi: Complete.

A3QDY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNFFAAAPR GYEYALSLEL AEFGAAEIKE SVAGVYFSAP LNLAYRITLW
60 70 80 90 100
SRLASRIILV IYKGPCENPE QLYNAAYCID WQTHFSNKSS FSIDFHGVGG
110 120 130 140 150
FIKNSQFGAL KIKDAVVDRF RDDGCPRPDV ARVDADFKID AHYRRGQITL
160 170 180 190 200
GINFSGPALH QRGYRSTTGE APLKENLAAN MLVRSGWQQS PKDLLDPFCG
210 220 230 240 250
SGTILIEAAM MACDIAPALQ RRRFGFEHWL RHQEADWQEL LAEAKARASI
260 270 280 290 300
GTKRCEIKFY GSDIDSRLVA LAKRNAQNAG VAELIELSVS NALNVTPPVE
310 320 330 340 350
QGYLITNPPY GERLGNVTSL LQLYYQLGDK LKAEFGGWQV AVLNSDIELL
360 370 380 390 400
SALKLKADKQ MKMYNGALEC AFNLYTLHAN STRRLDPSQV LSQGGEVSEV
410 420 430 440 450
ATAFSNRIKK NHKQLSKWAQ REGIDSYRLY DADIPEYNVA VDIYLDHVVI
460 470 480 490 500
QEYSAPKSIP EAVTKRRLTD VLLVLPQAIG VDPDKIILKT RERQKGTNQY
510 520 530 540 550
QKLDATKLEL VTTEYGAKFK LNLKDYLDTG LFLDHRLTRK LVGEKSKGRD
560 570 580 590 600
VLNLFAYTGS ASVHAALGGA KSVTTVDMSN TYLNWAQDNF ELNGLKGKQY
610 620 630 640 650
QFIQGDCLQW IDDCDQQYDL IFIDPPTFSN SKRMEDSFDV QRDHVKLLSA
660 670 680 690 700
LVKLLRPGGE ILFSNNKRKF KMDSEALSAL GLSITNLDKQ TLPLDYKRNP
710
HIHNTWLIQH A
Length:711
Mass (Da):79,892
Last modified:April 17, 2007 - v1
Checksum:i8BC6CAFE330CA57C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA. Translation: ABO23678.1.
RefSeqiWP_011865610.1. NC_009092.1.

Genome annotation databases

EnsemblBacteriaiABO23678; ABO23678; Shew_1812.
KEGGislo:Shew_1812.
PATRICi23515453. VBISheLoi132094_1809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA. Translation: ABO23678.1.
RefSeqiWP_011865610.1. NC_009092.1.

3D structure databases

ProteinModelPortaliA3QDY0.
SMRiA3QDY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi323850.Shew_1812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO23678; ABO23678; Shew_1812.
KEGGislo:Shew_1812.
PATRICi23515453. VBISheLoi132094_1809.

Phylogenomic databases

eggNOGiENOG4105C4H. Bacteria.
COG0116. LUCA.
COG1092. LUCA.
HOGENOMiHOG000218371.
KOiK12297.
OMAiMSNTYLN.
OrthoDBiPOG091H03PL.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL. 1 hit.
InterProiView protein in InterPro
IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
PfamiView protein in Pfam
PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiView protein in SMART
SM00981. THUMP. 1 hit.
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiView protein in PROSITE
PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMKL_SHELP
AccessioniPrimary (citable) accession number: A3QDY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 17, 2007
Last modified: March 15, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.